Developmental

Question 1

Maternal factors (7)

Answer 1

Increased PH
Increase ECF volume
Dec plasma albumin
Increased accumulation of fa
Delayed gastric emptying and decreased motility
Altered liver metabolism (slower)
Faster renal metabolism (faster)

Question 2

Placental Factors (9)

Answer 2

Different metabolic actions
Placental epithelial plates
Mechanism of drug transfers
Lipid solubility
Degree of ionization
Protein Binding
Specific placental transporters
Uterine blood flow
Maternal diseases

Question 3

Fetal Factors PK (7)

Answer 3

Fetal first pass
BBB permeability
Expanded ECF
Dec plasma protein and binding cap
Biotransforming enzymes
Primary routes of elimination
Fetal plasma and amniotic fluid

Question 4

Fetal factors PD (8)

Answer 4

Different relation to species

Periods of development leads to structural deformities

Maternal tissues affected 2ndarily to fetus

Drugs interfere with placental functions of O2

Drugs have delayed effects

Important direct actions on the process of differentiation

Continued exposure can produce cumulative effects