Diabetes Flashcards
(211 cards)
Alpha cells make_____
glucagon
Beta cells make _____
insulin
Delta cells make ______
somatostatin
Epsilon cells make _______
ghrelin
Diabetes mellitus is____
lack of insulin
Type I DM
-insulin dependent
Cause by: autoimmune mediated that can be triggered by virus or other toxic process in the environment
-In Type I DM—because there is no beta cell function—there is no basal insulin secreted nor is there a prandial [food related] response
TREATMENT: exogenous insulin
Type II DM
-Lack of sensitivity of target organs to insulin
-Pancreas has some beta cell function intact [at least—early on in the
disease process], but the secretion and action is not sufficient to keep
blood sugar normal
-Obese states contribute to the insulin resistance
Pathogenesis of type II diabetes
- Decreased insulin secretion
- Ineffective glucose uptake [skeletal muscle]
- Increased hepatic glucose production
- Decreased incretin effect
- Increased free fatty acid production
- Neurotransmitter dysfunction
- Increased glucose reabsorption
- Diminished beta cell response (insulin deficiency)
- Increased stimulus needed for beta cell function (insulin resistance)
- Decreased muscle uptake of glucose
- Impaired insulin secretion
- Increased hepatic glucose production
all of the above lead to hyperglycemia
Pancreas produces which peptide hormones
insulin
glucagon
somatostatin
4 categories of diabetes
- type 1
- type 2
- gestational
- diabetes d/t other causes
What can can type 2 cause
- Postprandial hyperglycemia
- Hyperinsulinemia from slow release
of insulin - Impaired insulin secretion—glucose
toxicity can occur - Increased hepatic glucose
production - Insensitivity to insulin in tissues
[hallmark of this disease]
Insulin resistance-causes and associated conditions
- aging
- obesity
- medications
- rare d/o
- genetics
- type 2 dm
- htn
- dyslipidemia
- atherosclerosis
- PCOS
Other Defects Do Occur—β
Cells vs. Tissue Receptors
- β cells in pancreas sense glucose levels→ leads to the production and release of insulin
- Receptors in tissue are part of auto-regulationsystem located in all organs
- Insulin on the receptors allow glucose transport into cells for utilization
- Defects in the receptors or defects in receptor response to insulin can lead to tissue insensitivity to insulin and increased glucose levels
Type I DM
- usually during childhood and puberty
- commonly undernourished
- moderate genetic predisposition
- beta cells are destroyed, eliminating the production of insulin
TYPE II DM
- commonly over age 35
- obesity usually present
- strong genetic predisposition
- inability of beta cells to produce appropriate quantities of insulin; insulin resistance; other defects
What medications are not 1st line for gestational DM bc they cross the placenta?
metformin and glyburide
Other less common type of diabetes
Diabetes related to disease of the exocrine pancreas—cystic fibrosis Diabetes from other endocrine dysfunction—Cushing syndrome, acromegaly, chromocytoma Drug induced diabetes—high dose corticosteroids
Causes of type II DM
-Lack of sensitivity of target organs to insulin
-Pancreas has some beta cell function intact [at least—early on in the disease process], but the secretion and action is not sufficient to keep
blood sugar normal
-Obese states contribute to the insulin resistance
Glucogenesis
is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates.
Glycolyisis
breaks down glucose into two three-carbon compounds and generates energy
What happens in insulin resistance?
- not enough insulin
- loss of insulin receptors
- loss of insulin receptor function
Downstream effects of insulin resistance?
- increased fatty acids in blood
- lipolysis for glucose
- decreased protein storage
What is lipolysis
metabolic process through which triacylglycerols (TAGs) break down via hydrolysis into their constituent molecules: glycerol and free fatty acids (FFAs)
DM + HTN + dyslipidemia are risk factors for?
ASCVD-atherosclerotic cardiovascular disease