DIABETES Flashcards
1
Q
Pathophysiology of T1DM
A
- immune response against beta cells
- beta cell destruction
- lack of insulin released
- GLUT-4 not activated
- glucose unable to be taken up by cells
- release of glucagon
- liver continues to release glucose
- hyperglycaemia
2
Q
Causes of T1DM
A
- autoimmune response against beta cells
- genetic susceptibility
- environmental factors
- Idiopathic
3
Q
Clinical manifestations of T1DM
A
- Polydipsia
- polyuria
- polyphagia
- fatigue
- weakness
4
Q
Pathophysiology of T2DM
A
- increased insulin resistance at the cell
- beta cell dysfunction leading to less insulin produced
- excess glucose produced by liver and muscles
- continued impaired glucose uptake and utilisation
- hypreglycaemia
5
Q
Causes of T2DM
A
- overweight/obesity
- age >35
- sedentary lifestyle
6
Q
Clinical manifestations of T2DM
A
- 3 P’s
- slow healing wounds
- weight loss
7
Q
Treatment of T1DM
A
Insulin
8
Q
Treatment of T2DM
A
- exercise
- diet
- insulin
9
Q
Complications of T1DM
A
- hypoglycaemia
- hyperglycaemia
- diabetic ketoacidosis (DKA)
10
Q
Complications of T2DM
A
- hypoglycaemia
- hyperglycaemia
- hyperosmolar hyperglycaemic state (HHS)
