Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Top 200 Drugs > Diabetes > Flashcards

Diabetes Flashcards

(111 cards)

Start Studying
1
Q

Lantus generic

A

Insulin glargine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Indications for Lantus

A

Type I and Type II diabetes mellitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lantus AEs

A

Hypoglycemia, injection site reactions, weight gain, hypokalemia, lipodystrophy, retinopathy, and insulin shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Lantus metabolism

A

hepatic and metabolic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Lantus interactions:

A

Alcohol, corticosteroids, thiazides, loop diuretics, oral contraceptives, beta blockers, ace inhibitors, ARBs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lantus contraindications

A

hypoglycemic episodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Lanuts Monitoring parameters

A

blood glucose, and A1C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does Lantus interact with alcohol

A

Increases the risk of hypoglycemia mainly in fasting patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does Lantus interact with corticosteroids?

A

decreases hypoglycemic effects of Lantus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How does Lantus interact with thiazides and loop diuretics?

A

decreases hypoglycemic effects of Lantus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does Lantus interact with oral contraceptives?

A

decreases hypoglycemic effects of Lantus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does Lantus interact with Beta blockers?

A

Increases the duration of hypoglycemic episodes and inhibits the symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How does Lantus interact with ACE inhibitors/ARBs?

A

increases hypoglycemic effects of insulin by improving insulin sensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Brand names of Insulin Aspart?

A

Novolog and humalog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Indications of insulin aspart?

A

type I or type II diabetes mellitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

AEs of insulin aspart

A

Hypoglycemia, injection site reaction, weight gain, hypokalemia, lipodystrophy, retinopathy, and insulin shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

metabolism of insulin aspart

A

hepatic and renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

interactions with insulin aspart

A

alcohol, corticosteroids, thiazides, loop diuretics, oral contraceptives, beta blockers,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

insulin aspart interaction with alcohol

A

increased risk of hypoglycemia especially in fasting patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

insulin aspart interaction with corticosteroids

A

decrease hypoglycemic effects of insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

insulin aspart interaction with thiazide and loop diuretics

A

decrease hypoglycemic effects of insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

insulin aspart interaction with oral contraceptives

A

decrease hypoglycemic effects of insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

insulin aspart interaction with beta blockers

A

increase the duration of hypoglycemic episodes and inhibit the symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

contraindications for insulin aspart

A

hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
monitoring of insulin aspart
blood glucose and A1C
26
Brand name of sitagliptin
Januvia
27
Januvia class
Dipeptidyl-peptidase IV (DPP-IV) inhibitor
28
Indications of Januvia
Type II diabetes mellitus
29
Dosage of Januvia
50 mg to 100 mg
30
AEs of Januvia
naso-pharyngitis, upper respiratory infection, peripheral edema, hypoglycemia renal failure
31
metabolism of Januvia
Renal (major) and hepatic
32
Interactions of Januvia
beta blockers, ACE inhibitors/ARBs, Thiazides, loop diuretics, cyclosporine, digoxin,
33
Januvia interaction with beta blockers
increase the duration of hypoglycemic episodes and inhibit the symptoms
34
Januvia interaction with ACE inhibitors / ARBs
increase the hypoglycemic effects of sitagliptin
35
Januvia interaction with Thiazides/loop diuretics
decrease the hypoglycemic effects of sitagliptin
36
Januvia interaction with cyclosporine
decrease the hypoglycemic effects of sitagliptin
37
Januvia interaction with digoxin
increase the AUC and Cmax of digoxin levels
38
contraindications of Januvia
angiodema
39
Monitoring for Januvia
blood glucose, A1C, serum creatinine/BUN, serum electrolytes, and serum lipase
40
Brand name of pioglitazone
Actos
41
Class of Actos
antidiabetic - thiazolidinediones
42
indications of Actos
type II diabetes mellitus
43
dosage range of Actos
15-45 mg orally daily
44
AEs of Actos
hypoglycemia, macular edema with visual impairment, weight gain and edema
45
metabolism of Actos
Hepatic (CYP 3A4, CYP 2C8)
46
Interactions with Actos:
oral contraceptives, CYP 3A4 inhibitors, Cyclosporine, tacrolimus, CYP 3A4 inducers
47
Cyp 3A4 inhibitors
erythromycin, itraconazole, verapamil, grapefruit juice, nefazodone, protease inhibitors)
48
CYP 3A4 inducers
phenytoin, st John's Wort oxcarbazepine
49
interaction of actos with oral contraceptives
decrease blood levels of the oral contraceptives
50
interaction of actos with cyp 3a4 inhibitors
increase blood levels of actos
51
interaction of actos with cyclosporine
increase hyperglycemia
52
interaction of actos with tacrolimus
increase hyperglycemia
53
interaction of actos with cyp 3A4 inducers
decrease blood levels of actos
54
contraindications of actos
acute heart failure or heart failure
55
monitoring parameters of Actos
blood glucose and LFTs
56
Brand name of insulin detemit
Levemir
57
Levemir indication
type 1 and 2 diabetes mellitus
58
AEs of Levemir
hypoglycemia, weight gain, hypokalemia, lipohypertrophy, insulin resistance, peripheral edema, and abdominal pain
59
metabolism of levemir
hepatic and renal
60
interactions with levemir
alcohol, corticosteroids, thiazides, loop diuretics, oral contraceptives, beta blockers, ace inhibitors, ARBs,
61
contraindications of levemir
hypoglemic episodes
62
monitoring parameters of levemir
blood glucose and A1c
63
Levemir interaction with alcohol
increase risk of hypoglycemia especially in fasting patients
64
levemir interaction with corticosteroids
decrease hypoglycemic effects of insulin detemir
65
levemir interaction with thiazides and loop diuretics
decrease hypoglycemic effects of insulin detemir
66
levemir interaction with oral contraceptives
decrease hypoglycemic effects of insulin detemir
67
levemir interactions with beta blockers
increase of the duration of hypoglycemic episodes and inhibit the symptoms
68
levemir interactions with ace inhibitors/ARBs
increase hypoglycemic effects of insulin by improving insulin sensitivity
69
brand names of exenatide
byetta, bydureon
70
exenatide class
insulin mimetics
71
indications of exenatide
type II diabetes mellitus
72
dosage range of exenatide
5-10 mcg subcutaneously twice a day, 2 mg subQ one weekly, within 60 minutes of a meal
73
AEs of exenatide
hypoglycemia, nausea/vomiting. hyperhidrosis, headache, injection site reaction, antibody formation
74
metabolism of exenatide
renal
75
interactions of exenatide
estrogens/progesterones, thiazides, triamterene, ACE inhibitors, ARBs
76
contraindications of exenatide
medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2 (MEN 2), thyroid cancer
77
monitoring of exenatide
blood glucose, A1C, serum creatinine and urinalysis
78
interaction of exenatide with estrogens/progesterones
decrease hypoglycemic effect of exenatide
79
interaction of exenatide with thiazides
decrease hypoglycemic effect of exenatide
80
interaction of exenatide with triamterene
decrease hypoglycemic effect of exenatide
81
interaction of exenatide with ACE inhibitors/ARBs
increase hypoglycemic effect of exenatide
82
Brand name of metformin
glucophage
83
metformin drug class
biguanide antidiabetic
84
indication of metformin
type II diabetes mellitus
85
Dosage range of metformin
500 mg oral twice daily or 850 mg orally once daily. doses > 2000 mg should be divided doses
86
AEs of metformin
GI effects, vitamin B 12 deficiency, weight loss, lactic acidosis, and hypoglycemia (less likely)
87
metabolism of metformin
renal
88
interactions of metformin
furosemide, thiazide diuretics, triameterene, digoxin, amiloride, cimetidine, adefovir, trimethoprim, oral contraceptives
89
contraindications to metformin
diabetic ketoacidosis, metabolic acidosis, radiographic contrast administration, renal failure
90
monitoring of metformin
blood glucose, A1c, CBC, serum creatinine/BUN
91
metformin interaction with furosemide
increase metformin plasma levels, hyperglycemia and glycosuria
92
metformin interaction with thiazides
decrease hypoglycemia effects of metformin
93
metformin interaction with digoxin
increase serum digoxin concentration
94
metformin interaction with amiloride
increase risk of lactic acidosis
95
metformin interaction with cimetidine
increase risk of lactic acidosis
96
metformin interaction with adefovir
increase risk of lactic acidosis
97
metformin interaction with trimethoprim
increase risk of lactic acidosis
98
metformin interaction with oral contraceptives
decrease hypoglycemic effects of metformin
99
metformin interaction with triameterene
decrease hypoglycemia effects of metformin
100
Brand name of repaglinide
Prandin
101
Prandin drug class
anti-diabetic Meglitinide derivative
102
Prandin indications
type II diabetes mellitus
103
Prandin initially dosing
nieve pts/ A1C > 8 : 0.5 mg before each meal | treated pts/ a1c < 8: 1-2mg before each meal
104
Prandin dosing range
0.5-4 mg before meals. 2-4 times per day
105
Contraindications to prandin
diabetic ketoacidosis, type I diabetes, concurrent gemfibrozil therapy
106
Pregnancy category of prandin
C
107
AEs of prandin
Headache, hypoglycemia, upper respiratory tract infection,
108
Metabolism of prandin
hepatic: CYP2C8, CYP 3A4, SLCO1B1
109
Monitoring of prandin
blood glucose, A1C,
110
MOA of prandin
blocks ATP dependent calcium channels to calcium entry stimulating release of insulin from beta cells (glucose dependent relesse)
111
Prandin drug interactions
Androgens, Atazanavir, Bosentan, Corticosteroids, cyclosporine, CYP 2C8 inducers/inhibitors, CYP 3A4 inducers/inhibitors, gemfibrozil, loop diuretics/thiazides, MAOIs, Macrolides, Rifampin, SSRIs, ST John's Wort, Trimethoprim

Top 200 Drugs (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions