Diabetes Flashcards Preview

Clinical Pharmacology > Diabetes > Flashcards

Flashcards in Diabetes Deck (20)
Loading flashcards...
1
Q

what is type 1 diabetes

A

this is where there is an autoimmune attack against the beta cells in the islets of langerhans so insulin isn’t produced

2
Q

what are the symptoms of type 1 diabetes

A

polydipsia
polyuria
weight loss

3
Q

why do type 1 diabetics get polydipsia

A

the increased amount of glucose in their blood increases their blood osmolality, activating their thirst response

4
Q

why do type 1 diabetic patients get polyuria

A

an increase amount of glucose in the tubules of the nephron means less water is reabsorbed as it affects the osmolality gradients

5
Q

what are the complications of type 1 diabetes

A

hyperglycaemia
ketoacidosis
dehydration
microvascular and macrovascular complications

6
Q

explain 3 types of insulin regimens are given to type 1 diabetics

A

basal - this is where injections of long acting insulin are given to give one constant background level of insulin
basal bolus - this is the same as basal except injections of fast/short acting insulin are given before meals
intermediate - this is where a mix of intermediate and long acting insulins are combined so the patient only needs 2 injections a day

7
Q

what happens in type 2 diabetes

A

there is a decrease in the sensitivity of insulin receptors

8
Q

name 4 types of oral hypoglycaemic therapies

A

metformin
sulphonylurea
GLP 1
glifozins

9
Q

what is the first choice drug for type 2 diabetes

A

metformin

10
Q

what does metformin do

A

increases insulin insensitivity

11
Q

what are the side effects of metformin

A

lactic acidosis and GI upset

12
Q

how does sulphonylurea work

A

stimulates beta cells to produce insulin

13
Q

what is a side effect of sulphonylurea

A

weight gain

14
Q

how does GLP 1 work

A

stimulates insulin secretion from beta cells and decreases glucagon secretion

15
Q

how do glifozins work

A

prevent the reabsorption of glucose in the PCT of the nephron so more glucose leaves in the urine

16
Q

what is a side effect of glifozins

A

increased risk of UTIs

17
Q

how do alpha glucosidase inhibitors work

A

prevent the breakdown of complex carbohydrates into glucose so less glucose is absorbed In the gut

18
Q

what is the normal level of HbA1c

A

6.5

19
Q

what is the role of insulin

A

increased glucose uptake in the liver, muscle and adipose
prevents the breakdown of fatty acids
increases glycogen production

20
Q

what are the adverse effects of insulin injections

A
  • painful
  • allergies
  • too much can result in hypoglycaemia