Flashcards in diabetes drug Deck (13):
ultra quick analogues
lispro, aspart and glulisine
short, rapid acting
neutral protamine hagedorn- hpa or so called isophase, or NP-aspart or NP-lispro
detemir, glargine, degludec
Second generation- glibenclamide, gliburide, glipizide, gliquidone, glimepiride, gliclazide
Adverse- hypo, tolerance, weight gain, appetitie increased, tolerance, hepatotoxic, allergy, gi.
shorter duration and quicker onset.
metformin and buformine (withdrawn)
1. amp protein kinase-> gluconeogenesis reduced.
2. uptake from GI reduced.
3. insulin resistence reduced.
4. lipid profile better.
adverse- lactic acidosis and persistent gi symtpoms
pioglitazone and rosiglitazone (withdrawn).
moa: ppargamma -increase glucose, lipid uptake and synthesis of fatty acid.
2. reduced resistnce.
takes 1-2 months to work
adverse- weight gain and fluid retention and increased mi risk (rosiglitazone)
saxagliptine, vildagliptine, sitagliptine and linagliptine.
lirgutide and exenatide
necrotizing hemorrhagic pancreatitis
acarbose and miglitol
dapagliflozin, canagliflozin, empagliflozin