diabetes drug Flashcards Preview

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Flashcards in diabetes drug Deck (13):
1

ultra quick analogues

lispro, aspart and glulisine

2

short, rapid acting

insulin

3

intermediate

neutral protamine hagedorn- hpa or so called isophase, or NP-aspart or NP-lispro

4

long acting

detemir, glargine, degludec

5

sulfynlurea

first generation-0
Second generation- glibenclamide, gliburide, glipizide, gliquidone, glimepiride, gliclazide

Adverse- hypo, tolerance, weight gain, appetitie increased, tolerance, hepatotoxic, allergy, gi.

6

glinides-

repaglinide, nateglinid-
shorter duration and quicker onset.
less adverse

7

biguanides

metformin and buformine (withdrawn)
1. amp protein kinase-> gluconeogenesis reduced.
2. uptake from GI reduced.
3. insulin resistence reduced.
4. lipid profile better.

adverse- lactic acidosis and persistent gi symtpoms

8

thiazolidendiones/ glitazone

pioglitazone and rosiglitazone (withdrawn).
moa: ppargamma -increase glucose, lipid uptake and synthesis of fatty acid.
2. reduced resistnce.
takes 1-2 months to work
adverse- weight gain and fluid retention and increased mi risk (rosiglitazone)

9

DDP4 inhibitors

saxagliptine, vildagliptine, sitagliptine and linagliptine.

10

incretin analogues

lirgutide and exenatide
Given parentally
necrotizing hemorrhagic pancreatitis

11

alpha-glucosidase inhibitors

acarbose and miglitol

12

SGLT-2 inhibitors

dapagliflozin, canagliflozin, empagliflozin

13

other less important drugs

colesevelam
bromocriptine
benfotiamine
thioctic acid
pramlintide