Diabetes - Other Inj

Question 1

GLP 1 RA once weekly and short acting

Answer 1

SHORT: exenatide, liraglutide, lixisenatide

ONCE a week: exenatide ER, dulaglutide, semaglutide

Question 2

GLP 1 RA AE

Answer 2

-Nausea, vomiting, diarrhea
-Dehydration (decreased appetite, dyspepsia, dizziness, headache, jitteriness)
-Delayed gastric emptying effects

Caution: pancreatitis risk, gallbladder, AKI

Question 3

Exenatide (Byetta®)

Answer 3

inject SQ within 1 hr before a meal TWICE a day

skip any missed dose, no doubling

Question 4

Liraglutide (Victoza)

Answer 4

-0.6 mg daily for 1 week, then 1.2 daily for 1 week, then 1.8 daily

Question 5

Saxenda (liraglutide FDA approved for weight loss)

Answer 5

-0.6 daily, increase by 0.6 each week until 3 max

Question 6

Lixisenatide (adlyxin)

Answer 6

20 mcg daily
-HS rxn, anaphylaxis

Question 7

Bydureon Bcise Pen (Exenatide ER)- Administration

Answer 7

-remove from fridge 15 min before use
-shake 15 times
-cloudy, no particles
-once a wk inj

Question 8

Dulaglutide (Trulicity)

Answer 8

0.75 mg sc once a week, then 1.5 mg

missed dose: give if within 3 days

warning: Diabetic Retinopathy Complication

Question 9

Once Weekly Semaglutide (Ozempic)

Answer 9

-Start with 0.25 mg once weekly x4 weeks
-Then 1 mg once weekly for 4 weeks then 2 if needed

Avoid in patients with retinopathy or high risk for retinopathy

Question 10

Semaglutide Injectable: Additional FDA Approval for Weight Loss (Wegovy)

Answer 10

-Titrate over 16-20 weeks up to 2.4 mg once a week

Question 11

Tirzepatide (Mounjaro)

Answer 11

-2.5 mg once a week for 4 weeks
-Increase by 2.5 increments every 4 weeks until max of 15

Question 12

IV Infusion: Teplizumab (Tzield)

Answer 12

-over 30 min, once daily for 14 days

AE: low WBC, rash, HA, infection, cytokine syndrome

-childhood vaccines must be administered prior to use, avoid live/inactivated vaccines