DIC

Question 1

inappropriate activation of the […] cascades, resulting in […] formation and depletion of […] factors and […]

Answer 1

inappropriate activation of the clotting cascades, resulting in thrombus formation and depletion of clotting factors and platelets.

Question 2

Presentation
- Excess […] e.g. epistaxis, gingival bleeding, haematuria, bleeding from […] sites.
- Patients may also present with […], confusion, or […].

Answer 2

• Excess bleeding e.g. epistaxis, gingival bleeding, haematuria, bleeding from cannula sites.
• Patients may also present with fever, confusion, or coma.

Question 2

Presentation
- Excess […] e.g. epistaxis, gingival bleeding, haematuria, bleeding from […] sites.
- Patients may also present with […], confusion, or […].

Answer 2

• Excess bleeding e.g. epistaxis, gingival bleeding, haematuria, bleeding from cannula sites.
• Patients may also present with fever, confusion, or coma.

Question 3

Risk factors
Major […] or burns
Multiple organ failure
Severe […] or […].
Severe […] complications
Solid tumours or […] malignancies

Answer 3

Major trauma or burns
Multiple-organ failure
Severe sepsis or infection.
Severe obstetric complications
Solid tumours or haematological malignancies

Question 4

What uncommon subtype of acute myelogenous leukaemia is associated with DIC

Answer 4

Acute promyelocytic leukaemia (APL)

Question 5

Investigations
[…]
Increased […] time
Increased fibrin degradation products (such as […]-[…])
Decreased […]

Answer 5

Thrombocytopenia
Increased prothrombin time
Increased fibrin degradation products (such as D-dimer)
Decreased fibrinogen