Differentials and workups Flashcards

1
Q

Basic presentation, differential, and workup for appendicitis?

A

Vague pain around the umbilicus that becomes sharp and migrates to McBurney’s point. Usually with nausea, vomiting (after pain onset), and fever. Psoas, obturator, and McBurney sign are positive.

Gastroenteritis
Nephrolithiasis
Ovarian cyst or tortion
Crohn disease

CBC, with differential
Electolytes
Blood culture
U/S abdomen
CT abdomen
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2
Q

Basic presentation, differential, and workup for acute pancreatitis?

A

Severe midepigastric pain that radiates to the back and improves when leaning forward. Accompanied by anorexia, nausea, and vomiting. Worse after eating.

Peptic ulcer disease
Cholecystitis
Gastritis

CBC
Electrolytes, calcium
BUN/Cr
Amylase, Lipase
ALT, AST, Alkaline phospatase, bilirubin
U/S abdomen
CT abdomen
ECG
Upper endoscopy
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3
Q

Basic presentation, differential, and workup for nephrolithiasis?

A

Colicky, flank pain that radiates to the inguinal region. With nausea, vomiting, hematuria, and CVA tenderness.

Pyelonephritis
RCC
Appendicitis
Diverticulitis
Ovarian cyst or torsion
CBC
Electolytes, calcium
BUN/Cr
Blood culture
UA
urine culture with sensitivities
CT abdomen
U/S renal
KUB x-ray
intravenous pyelogram
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4
Q

Basic presentation, differential, and workup for acute cholecystitis?

A

RUQ abdominal pain that radiates to the right scapula after eating fatty food. Lasts for more than 3 hours. Associated with nausea, vomiting, and fever. Positive Murphy’s sign.

Choledocholithiasis
Peptic ulcer disease
Ascending cholangitis
Hepatitis

CBC, differential
Electrolytes
AST, ALT, alkaline phosphatase, bilirubin
Blood culture
U/S abdomen
CT abdomen
Hepatitis serologies
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5
Q

Basic presentation, differential, and workup for Peptic ulcer disease?

A

Epigastric pain that is exacerbated or relieved by eating.

Gastritis
GERD
Cholecystitis
Chronic pancreatitis

CBC
Electrolytes
Amylase, Lipase
AST, ALT, alkaline phosphatase, bilirubin
Rectal exam with stool for occult blood
Upper endoscopy
Upper GI series
CXR
Urea breath test
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6
Q

What is the differential for severe, acute, diffuse abdominal pain?

A
Peritonitis
Bowel obstruction (vomiting)
Mesenteric ischemia (pain disproportionate to tenderness)
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7
Q

Basic presentation, differential, and workup for dysphagia?

A

Difficulty swallowing liquids, solids, or both. ±odynophagia, ±nausea/vomiting

Esophageal stricture
Zenker Diverticulum
Achalasia
Esophagitis

CBC
Electrolytes
Serum iron, ferritin, TIBC
CXR
Barium swallow
Upper endoscopy
Esophageal manometry
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8
Q

Basic presentation, differential, and workup for GERD?

A

Burning retrosternal chest pain
±sour taste, odynophagia, nocturnal asthma

Esophagitis
Esophageal spasm
Angina
MI

CBC
Electorlytes
ECG
Barium swallow
Upper endoscopy
Esophageal pH monitoring
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9
Q

Basic presentation, differential, and workup for bloody diarrhea?

A
Acute:
Shigella
Salmonella
Campylobacter
EHEC
Chronic:
UC
Crohn's
Diverticulitis
Malignancy
CBC
Electrolytes
Stool: leukocytes, culture, ova, and parasites, C. diff toxin
rectal exam + stool for occult blood
CT abdomen
p-ANCA, ASCA
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10
Q

Basic presentation, differential, and workup for watery diarrhea?

A
Lactose intolerance
Cryptosporidium
C. diff
IBS
giardiasis
amebiasis
food poisoning
hyperthyroidism
CBC
Electolytes
Hydrogen breath test
Stool leukocytes, culture, ova and parasits, C. diff toxin
Rectal exam + stool for occult blood
giardia antigen
entamoeba histolytica antigen
TSH, FT4
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11
Q

What conditions cause mucus in diarrhea?

A

IBS
colonic adenocarcinoma
polyps

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12
Q

What condtions cause pus in diarrhea?

A

UC
Crohn’s
Diverticulitis

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13
Q

Basic presentation, differential, and workup for constipation?

A

Low fiber diet
Colon cancer
Hypothyroidism
Substance abuse

CBC
Electrolytes
Rectal exam + occult blood
TSH
Urine toxocology
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14
Q

Basic presentation, differential, and workup for watery dysphagia?

A

Trouble swallowing

Neurological:
Achalasia
Diffuse esophageal spasm

Mechanical:
Esophageal stricture, possibly malignant
Zenker diverticulum
Left atrial hypertrophy

Other:
Esophagitis

CBC
Electorlytes
Barium swallow
Upper endoscopy
Esophageal manometry
CXR
Serum iron, ferritin, TIBC
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15
Q

Basic presentation, differential, and workup for nausea and vomiting?

A
Hyperemesis gravidarum
gastritis
food poisoning
idiopathic intracranial hypertension
hypercalcemia
diabetes mellitus
CBC
Electrolytes, calcium, glucose
urine hCG
UA with culture
pelvic exam
abdominal U/S
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16
Q

Basic presentation, differential, and workup for blood in the stool?

A

Melena vs bright red

Colon Ca
Hemorrhoids
Anal fissure
Diverticulosis
UC
Crohn's
Large upper GI bleed
CBC
Electrolytes
Rectal exam
Colonoscopy
CT abdomen/pelvis
PT, PTT, INR
ALT, AST, alkaline phosphatase, bilirubin
CEA
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17
Q

Basic presentation, differential, and workup for Upper GI bleed?

A

Coffee ground emesis, melena, possibly hematochezia

Gastritis
Peptic ulcer
Esophageal varices
Gastric Cancer
Mallory-Weiss tear
Electrolytes
Rectal exam + occult blood
CBC, type and cross
AST, ALT, alkaline phosphatase, bilirubin
PT, PTT, INR
Upper endoscopy
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18
Q

Basic presentation, differential, and workup for headaches?

A
Tension
Migraine
Cluster
Sinusitis
Temporal arteritis
Meningitis
Subarachnoid hemorrhage
Trigeminal neuralgia
CBC
Electrolytes
CRP
ESR
CT head
LP - opening pressure
MRI brain
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19
Q

Basic presentation, differential, and workup for low back pain?

A
Lumbar muscle strain
Disc herniation
Lumbar spinal stenosis
Vertebral compression fracture
Ankylosing spondylitis
Osteomyelitis
Epidural abscess

Straight leg raise

Xray lumbar spine
MRI lumbar spine
HLA-B27
CRP
ESR
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20
Q

Basic presentation, differential, and workup for jaundice?

A

Obstructive:
pancreatic cancer
Choledocholithiasis
Liver mets

Hepatocellular:
Hepatitis (viral, alcoholic, hemochromatosis, wilsons)
Right heart failure

Prehepatic:
Hemolysis
Ineffective erythropoesis
glucuronyl transferase deficiency

CBC
Reticulocyte count
Electrolytes
AST, ALT, alkaline phosphatase, bilirubin
albumin
haptoglobin
LDH
EBV, CMV, hepatitis serologies
Serum iron, ferritin, TIBC
Serum ceruplamin
Abdominal CT
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21
Q

What is the tetrad of narcolepsy?

A

Daytime sleepiness
Hypnagogic hallucinations
Cataplexy
Sleep paralysis

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22
Q

Basic presentation, differential, and workup for insomnia?

A
Stress induced insomnia
Caffeine induced insomnia
Insomnia with circadian rhythm sleep disorder
Insomnia related to major depression
OSA
Primary hypersomnia
Narolepsy

Polysomnoram
Nocturnal pulse ox
EEG

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23
Q

Basic presentation, differential, and workup for night sweats?

A
Hyperthyroidism
Tuberculosis
Acute HIV infection
Lymphoma
Leukemia
Pheochromocytoma
Carcinoid syndrome
CBC with differential
Electrolytes
CXR
PPD/QuantiFERON Gold
Sputum gram stain acid fast
HIV antibody
24 hour urine catecholamines
5-HIAA
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24
Q

Basic presentation, differential, and workup for Lightheadedness?

A

Orthostatic hypotension

  • dehydration
  • drug induced

Orthostatic vital signs
CBC
Electrolytes
Rectal exam for occult blood

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25
Basic presentation, differential, and workup for vertigo?
BPPV (lasts minutes with movement) Menieres Disease (20min to hours w/hearing loss tinnitus, +/- N/V or drop attacks Acoustic neruoma (gradual onset +hearing loss) Vestibular neuritis (sudden onset +N/V, -hearing loss -tinnitus) Larynthitis (+N/V, +hearing loss, +tinnitus) Vertebrobasilar insufficiency (-hearing loss +focal neuro) ``` Dix-Hallpike manouver Epley manouver CBC Electrolytes MRI/MRA - brain Audiogram VDRL/RPR Electronystagmography ```
26
Basic presentation, differential, and workup for deafness?
Conductive: Cerumen impaction Otosclerosis Otitis media Sensory: Auditory nerve damage Labrinthitis Acoustic neruoma Audiogram MRI - brain CT - head Weber lateralizes to good side in sensorineural loss Renne BC>AC in conductive loss on affected side
27
Basic presentation, differential, and workup for loss of consciousness?
``` Generalized tonic-clonic seizure Drug-induced orthostatic hypotension Cardiac arrythmia Hypoglycemia Severe aortic stenosis Substance abuse ``` ``` CBC Electrolytes EEG ECG 24 hour Holter monitor Urine tox CT-head LP-CSF analysis MRI-brain Echocardiogram ```
28
Basic presentation, differential, and workup for Numbness/weakness?
``` Stroke TIA Seizure - Todd's paralysis Guillian-Barre Syndrome Myasthenia Gravis Lambert-Eaton CNS tumor Subdural or epidural hematoma MS ``` ``` CT - head MRI - brain CBC Electrolytes PT/PTT Carotid doppler EEG ECG Echocardiogram LP - CSF analysis B12 Tensilon test EMG ```
29
Basic presentation, differential, and workup for loss of vision?
Retinal artery occlusion Retinal vein occlusion Acute angle-closure glaucoma ``` CBC Electrolytes PT/PTT Flourescein angiogram Carotid doppler Echocardiogram Intaocular tonometry ```
30
Basic presentation, differential, and workup for Depression?
``` Major depression Bipolar I or II Bereavement Dysthymic disorder Hypothyroidism Substance abuse ``` Beck depression inventory Urine tox TSH
31
What is PH9?
``` Depressed mood Anhedonia Changes in sleep Changes in appetite Trouble concentrating Decreased energy Psychomotor depression Feelings of guilt or worthlessness Thoughts of self harm ```
32
Basic presentation, differential, and workup for confusion and memory loss?
``` Alzheimer disease Vascular dementia Normal pressure hydrocephalus Lewy body dementia Anterofrontal dementia Depression (pseudodementia) Chronic subdural hematoma B12 deficiency Hypothyroidism Wernicke's Encephalopathy Delerium Intracranial neoplasm ``` ``` CBC Electrolytes TSH B12 VDRL/RPR CT - head LP - opening pressure, CSF analysis MRI - brain ```
33
Basic presentation, differential, and workup for psychosis?
``` Schizophrenia Schizophreniform disorder Schizoaffective disorder Psychotic disorder due to general medical condition Substance induced psychosis ``` ``` MSE Urine toxicology CBC Electrolytes TSH Beck depression inventory ```
34
Basic presentation, differential, and workup for fatigue and sleepiness?
``` Depression Hypothyroidism Cancer OSA DM II Anemia Narcolepsy Shift work sleep disorder ``` ``` Beck depression inventory TSH, fT3, fT4 CBC Electrolytes Urine toxicology Glucose tolerance test HbA1c Nocturnal Pulse ox Polysomnography ```
35
Basic presentation, differential, and workup for sore throat?
``` Viral pharyngitis Bacterial pharyngitis Mononucleosis Acute HIV infection Streptococcal tonsilitis Secondary syphilis Mycoplasma pneumonia Post nasal drip ``` ``` CBC w/ differential, and peripheral smear Electrolytes Throat culture HIV antibody Monospot test anit-EBV antibodies Rapid strep test ALT,AST,alkaline phosphatase, bilirubin VDRL/RPR Cold agglutinin for mycoplasma ```
36
Basic presentation, differential, and workup for cough?
``` Asthma Bronchitis GERD COPD (or exacerbation) Pneumonia Atypical pneumonia Lung cancer Tuberculosis Heart failure ``` ``` CBC Electrolytes Sputum gram stain, culture, and acid fast stain PFTs CXR ECG Echocardiogram BNP ```
37
Basic presentation, differential, and workup for chest pain?
``` MI PE Angina Pneumonia Aortic dissection Pericarditis Pleurisy Costochondritis Pneumothorax ``` ``` ECG CXR CBC Electrolytes CPK-MB + troponin x3 Echocardiogram d-dimer CT-chest CTA-chest US doppler LEs ```
38
Basic presentation, differential, and workup for palpitations?
``` Hyperthyroidism Hypoglycemia Cardiac arrhythmia Panic attack Pheochromocytoma Carcinoid syndrome Substance abuse ``` ``` CBC Electrolytes TSH, fT4 ECG Blood glucose 24 hour urine catecholamines 5-HIAA Urine toxicology ```
39
Basic presentation, differential, and workup for weight loss?
``` Hyperthyroidism DM Cancer HIV Tuberculosis Anorexia nervosa Malabsorption Substance abuse - dieting drugs ``` CBC Electrolytes, glucose TSH, fT4
40
Basic presentation, differential, and workup for weight gain?
``` Hypothyroidism Smoking cessation Drug side effect Cushing syndrome Polycystic ovarian syndrome DM Atypical depression ``` ``` CBC Electrolytes, glucos TSH 24 hour urine free cortisol Dexamethasone suppression test ```
41
Basic presentation, differential, and workup for Neck mass?
Hodgkin's/Non-Hodgkin's lymphoma Tuberculosis Thyroid nodule Gastric carcinoma ``` CBC w/ differential Electrolytes ESR CRP PPD TSH CXR US thyroid Upper endoscopy ```
42
Basic presentation, differential, and workup for Hematuria?
``` UTI Nephrolithiasis Bladder Ca RCC Acute glomerulonephritis Prostate Ca Coagulation disorder Pyelonephritis PKD ``` ``` Genitourinary exam UA, urine cytology BUN/Cr CBC Electrolytes PT/PTT US renal, bladder Cystoscopy CT - abdomen/pelvis PSA ```
43
Basic presentation, differential, and workup for urinary obstruction?
``` BPH Prostate Ca UTI Bladder Stones RCC ``` ``` Genitourinary exam Rectal exam PSA CBC Electrolytes Alkaline phosphatase UA, urine culture and cytology US - prostate ```
44
Basic presentation, differential, and workup for dysuria?
``` UTI -urethritis -cystitis -prostatitis -pyelonephritis Nephrolithiasis Prostatitis Chlamydia Gonorrhea ``` ``` CBC Electrolytes UA, urine culture and sensitivity BUN/Cr Gram stain and culture of discharge Chlamydia and gonorrhea PCR US - renal CT - abdomen/pelvis ```
45
Basic presentation, differential, and workup for incontinence?
``` Stress incontinence Urge incontinence Mixed incontinence Overflow incontinence Functional incontinence UTI DM ``` ``` CBC Electrolytes, glucose BUN/Cr UA, urine culture urodynamic testing IVP Cystourethroscopy ```
46
Basic presentation, differential, and workup for amenorrhea?
``` Pregnancy Anovulatory cycle Polycystic ovarian syndrome Hyperprolactinemia Premature ovarian failure Thyroid disease Pituitary tumor Ovarian or adrenal malignancy Menopause Sheehan's syndrome Anorexia nervosa ``` ``` CBC Electrolytes Urine hCG Pelvic exam US - abdomen/pelvis Prolactin TSH LH/FSH Testosterone MRI - brain ```
47
Basic presentation, differential, and workup for vaginal bleeding?
``` Dysfunctional uterine bleeding Coagulation disorder Cervical cancer Molar pregnancy Cervical cancer Molar pregnancy Cervical polyp Endometrial hyperplasia Atrophic endometrium Endometrial polyp Cervicitis Atrophic vaginitis Trauma Ectopic pregnancy Ruptured ovarian cyst Ovarian torsion PID Hypothyroidism Spontaneous abortion ``` ``` CBC Electrolytes Urine hCG US abdomen/pelvis Pelvic exam Pap smear cervical culture PT/PTT Colposcopy Hysteroscopy Quantitative serum hCG US - abdomen/pelvis ```
48
Basic presentation, differential, and workup for vaginal discharge?
Bacterial vaginosis Candidal vaginitis Trichomonal vaginitis Cervicitis - chlamydia, gonorrhea ``` CBC Electrolytes Pelvic exam Wet mount KOH prep, "whiff test" pH of vaginal fluid Cervical cultures ```
49
Basic presentation, differential, and workup for dyspareunia?
``` Atrophic vaginitis Endometriosis Cervicitis Vaginismus Vulvodynia PID Depression Domestic violence ``` ``` CBC Electrolytes Pelvic exam LH/FSH Wet mount KOH prep Cervical cultures US - pelvis Endometrial biopsy ```
50
Basic presentation, differential, and workup for abuse?
``` Domestic violence Osteogenesis imperfecta Substance abuse Consensual violent sexual behavior Factitious disorder RAPE ``` ``` XR - skeletal survey CT - maxillofacial urine toxicology CBC Electrolytes ``` ``` RAPE Sexual Assault Forensic Evidence collection kit Pelvic exam Urine hCG Wet mount KOH prep Cervical cultures NAAT - chalmydia and gonorrhea Xray skeletal servey HIV antibody Viral hepatitis serologies ```
51
Basic presentation, differential, and workup for carpal tunnel?
Carpal tunnel syndrome Median nerve compression in the forearm or arm Radiculopathy of C6 - C7 nerve roots De Quervain's tenosynovitis ``` Phalen's manuever Tinel's sign Finklestein's test Nerve conduction studies EMG ```
52
Basic presentation, differential, and workup for hip fracture?
Hip fracture Hip dislocation Pelvic fracture ``` X-ray - pelvis/hip CT - hip CBC, type and cross Electrolytes, calcium DEXA scan ```
53
Basic presentation, differential, and workup for osteoarthritis of knee?
Osteoarthritis - knee Pseudogout Gout ``` X-ray - knee CBC Electrolytes ESR Uric acid MRI - knee Arthrocentesis and synovial fluid analysis -cell count, gram stain, culture, crystals ```
54
Basic presentation, differential, and workup for Septic arthritis knee?
``` Septic arthritis knee Gout Pseudogout Lyme arthritis Reiter's syndrome Disseminated gonorrhea ``` ``` CBC Electrolytes PT/PTT Arthrocentesis, synovial fluid analysis -cell count, gram stain, culture, crystals Blood cultures x2 UA, urine culture X-ray knee Uric acid Lyme titers ```
55
Basic presentation, differential, and workup for stress fracture?
Foot pain after exercise Stress fracture Plantar fasciitis Foot sprain X-ray foot MRI - foot Bone scan foot
56
Basic presentation, differential, and workup for tennis elbow?
lateral epicondylitis Stress fracture Cozen's test X-ray - arm Bone scan MRI - elbow
57
Basic presentation, differential, and workup for golfers elbow?
medial epicondylitis Little leaguer's elbow UCL injury X-ray - arm Bone scan MRI - elbow
58
Basic presentation, differential, and workup for claudication?
Peripheral vascular disease Leriche syndrome - aortoiliac occlusive disease Lumbar spinal stenosis Ankle-brachial index Dobbler US of lower extremities Angiography MRI lumbar spine
59
Basic presentation, differential, and workup for DVT?
DVT Baker's cyst rupture Cellulitis ``` CBC Electrolytes, calcium PT/PTT d-dimer Doppler US lower extremities ```
60
Basic presentation, differential, and workup for Left arm pain on exertion?
``` Angina MI Tendonitis Bursitis Osteoarthritis ``` ``` ECG CBC X-ray shoulder CXR Echocardiography Stress test ```
61
Basic presentation, differential, and workup for Shoulder dislocation?
Shoulder dislocation Proximal humerus fracture Rotator cuff injury Torn labrum X-ray - shoulder X-ray - arm MRI shoulder
62
Basic presentation, differential, and workup for muscle pain?
Rhabdomyolysis from statins Polymyositis Inclusion body myositis ``` CBC Electrolytes Phosphate Potassium BUN/Cr Calcium Uric acid CPK Aldolase ALT/AST UA Urine myoglobin ```
63
Basic presentation, differential, and workup for child with short stature?
``` Constitutional short stature Growth hormone deficiency Hypothyroidism Chronic renal insufficiency Genetic causes Cystic fibrosis ``` ``` Physical exam CBC Electrolytes IGF-1 IGFBP-3 GH stimulation test TSH, fT4 X-ray hand US renal/cardiac Sweat chloride test BUN/Cr Karyotype ```
64
Basic presentation, differential, and workup for child with behavioral problems?
``` ADHD Oppositional defiant disorder Conduct disorder Manic episode Hyperthyroidism Adjustment disorder Substance abuse Age appropriate behavior ``` ``` Physical exam Mental status exam Urine toxicology TSH EEG ```
65
Basic presentation, differential, and workup for baby crying for weeks?
Crying or weeks relieved by flatus or eruction - no vomiting, constipation, or fever - no change in appetite, weight, or growth ``` Colic Formula allergy GERD Lactose intolerance Strangulated hernia Testicular torsion ``` Physical eam Rectal exam + stool for occult blood US - abdomen, testicular
66
Basic presentation, differential, and workup for pink eye?
``` started in one eye now in both +mucoid discharge +itching +difficulty opening eyes in AM +photophobia ``` ``` Bacterial conjunctivitis Viral conjunctivitis Keratitis Uveitis Seasonal allergies ``` ``` Physical exam Opthalmoscopic exam CBC Electrolytes Discharge cultures Slit lamp exam ```
67
Basic presentation, differential, and workup for an infant with colicky abdominal pain and vomiting?
Abdominal pain, with vomiting, bloody stools Well between episodes ``` Intussusception Appendicitis Meckel's diverticulum Volvus Gastroenteritis Entercolitis Trauma ``` ``` Physical exam Rectal exam + occult blood CBC Electrolytes Contrast enema US abdomen CT abdomen ```
68
Basic presentation, differential, and workup for child with abdominal pain at convenient times?
``` Worse in morning better on weekends and holidays Missed school a lot Normal growth and development +/- Emotional trauma Malingering Somatoform disorder IBS Lactose intolerance Child abuse ``` ``` Physical exam CBC Electrolytes US - abdomen CT - abdomen Amylase, lipase Stool exam ```
69
Basic presentation, differential, and workup for an infant with vomiting?
``` Pyloric stenosis Partial duodenal atresia GERD Gastroenteritis Hepatitis UTI ``` ``` Physical exam CBC Electrolytes US - abdomen Barium swallow pH probe Endoscopy ```
70
Basic presentation, differential, and workup for a child with constipation?
Hirschprung's disease Low fiber diet Anal stenosis Hypothyroidism ``` Physical exam Rectal exam Stool exam culture Barium enema Anorectal manometry Suction rectal biopsy ```
71
Basic presentation, differential, and workup for a child with measles?
Fever + rash, not immunized ``` Rubella Roseola Fifth disease Varicella Scarlet fever Meningitis ``` ``` Physical exam CBC Viral antibodies/titers Throat swab for cultures CT - head LP - CSF analysis ```
72
Basic presentation, differential, and workup for a child with gastroenteritis?
Fever, diarrhea, lethargy, and weakness ``` Viral gastroenteritis Bacterial gastroenteritis Parasitic gastroenteritis Food poisoning UTI URI Volvus Intussception ``` ``` Physical exam Stool exam, culture, parasites and ova CBC Electrolytes UA, urine culture AXR ```
73
Basic presentation, differential, and workup for neonatal sepsis?
Fever, decreased breast feeding, and lethargy Neonatal sepsis Meningitis Pneumonia Pyelonephritis ``` Physical exam CBC Electrolytes Blood culture x2 LP - CSF analysis CXR UA, urine culture ```
74
Basic presentation, differential, and workup for a child with acute otitis media?
Fever, ear pulling URI Meningitis Pyelonephritis ``` Physical exam with otoscopy CBC Blood culture Tympanocentesis + culture LP + CSF analysis UA, urine culture ```