Digestive Glands and Liver II

Question 1

What is the portal view of the hepatic lobules?

Answer 1

• three central venules of adjacent lobules form a triangle

- portions of the bile canaliculi of the three lobules drain into the same bile duct.

Question 2

What is the liver acinus view of the hepatic lobules?

Answer 2

three zones defined by hepatic tissue receiving blood from a branch of the hepatic artery conducting blood to opposite central veins.
-metabolic gradient extends from hepatic triad to central vein.

Question 3

What is a portal triad?

Answer 3

-branch of hepatic artery
-branch of portal vein
-bile duct
they are found at corners of classic lobule

Question 4

What is the structure of a hepatocyte?

Answer 4

• polyhedral shaped
• central nucleus (may have multiple)
• basolateral microvilli

Question 5

What type of hepatocyte is most susceptible to damage?

Answer 5

Zone III hepatocytes because

Question 6

Where is the space of Disse located?

Answer 6

The space of Disse is located between the endothelial cells of the hepatic sinusoids and hepatocyte plate.

Question 7

Where does the space of Disse drain into?

Answer 7

The space of Disse drains its contents into lymphatic vessels and the llymphatic system

Question 8

What is found within the cytoplasm of hepatocytes?

Answer 8

glycogen, fat droplets, and pigment granules

Question 9

What surface of the hepatocyte is associated with the space of Disse?

Answer 9

The basolateral domain of the hepatocyte

Question 10

What surface of the apical domain is associated with the borders of bile of canaliculus?

Answer 10

The apical domain of hepatocytes

Question 11

What occurs to perisinusoidal cells during cirrhosis of the liver?

Answer 11

• Perisinusoidal cells transform into myofibroblasts

- become the main collagen type I producing cells

Question 12

Where is the subendothelial space of Disse and what does it contain?

Answer 12

• space between basal lamina and hepatocytes
• contains micorvilli of basolateral domain of hepatocytes
• contains types I, III, IV collagens
• Contains interstitial fluid that drains into the space of Mall that drains into lymphatics

Question 13

What are kupffer cells?

Answer 13

• phagocytic cell
• derived from monocytes
• lines hepatic sinusoids.

Question 14

What is the function fo the canal of Hering?

Answer 14

• receives bile from canaliculus

- carries bile to bile ductule

Question 15

What are the 4 structures that make up the gall bladder?

Answer 15

• fundus
• body
• neck
• wall

Question 16

What are the 3 layers of the wall of the gall bladder?

Answer 16

• mucosa
• muscularis externa
• serosa

Question 17

What type of epithelium is found in the mucosal wall of the gall bladder?

Answer 17

tall columnar with a striated border.

Question 18

What are Rokitansky- Aschoff sinuses?

Answer 18

small diverticuli of the mucosa which extend into the muscular and perimuscular layers and may indicate pathological change

Question 19

What is the difference between the hepatic duct, cystic duct, and common bile duct?

Answer 19

• hepatic duct: collects bile form hepatocytes
• cystic duct: duct leading to the gall bladder that bile from hepatic duct can travel up to be stored in the gall bladder
• common bile duct: takes bile from the gall bladder to the duodenum.

Question 20

What is the classic view of the hepatic lobules?

Answer 20

central venule is in the center of the lobules and portal triads are at the angles.