Direct acting muscarinic agonists

Question 1

What is the MOA for direct acting muscarinic agonist cholinomimetic drugs?

Answer 1

Bind to and activate muscarinic (and nicotinic)
receptors with different selectivity

Question 2

What are the two types of Cholinomimetic drugs?

Answer 2

Direct and Indirect acting cholinomimetic drugs

Question 3

What are the types of direct acting cholinomimetic drugs?

Answer 3

Muscarinic agonists and Nicotinic agonist

Question 4

What are the types of direct acting cholinomimetic drugs?

Answer 4

Cholinesterase inhibitors

Question 5

What are the clinical uses for direct acting muscarinic agonist cholinomimetic drugs?

Answer 5

Postoperative Ileus (paralysis of stomach/bowel)
Urinary retention
Xerostomia (dry mouth)
Glaucoma (increased intraocular pressure)

Question 6

How are direct acting muscarinic agonist used to treat Postoperative Ileus?

Answer 6

Increasing secretory and motor activity of the gut

Question 7

How are direct acting muscarinic agonist used to treat urinary retention?

Answer 7

Stimulate the detrusor muscle to contract

Question 8

How are direct acting muscarinic agonist used to treat glaucoma?

Answer 8

Contraction of the ciliary and pupillary constrictor muscle
facilitates drainage of fluid

Question 9

What are the adverse effects for direct acting muscarinic agonist cholinomimetic drugs?

Answer 9

GIT: diarrhea, abdominal cramps, nausea/vomiting
Urinary urgency
Vision problems

Question 10

What are the contraindications for direct acting muscarinic agonist cholinomimetic drugs?

Answer 10

Asthma/ COPD (Chronic Obstructive Pulmonary
Disease)
Urinary or GI tract obstruction

Question 11

What are the contraindications for direct acting muscarinic agonist cholinomimetic drugs?

Answer 11

Asthma/ COPD (Chronic Obstructive Pulmonary
Disease)
–Urinary or GI tract obstruction