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1 STEP General pharm (UW ir FA) > direct sympatomimetics > Flashcards

direct sympatomimetics Flashcards

1
Q

midodrine receptors?

A

alpha 1

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2
Q

NE receptors?

A

alpha1>alpha2>beta1

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3
Q

phenylephrine receptors?

A

alpha1>alpha2

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4
Q

which drug acts only on alpha1?

A

midodrine

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5
Q

which drug acts on alpha1>alpha2»beta1?

A

NE

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6
Q

which drug acts on alpha1>alpha2?

A

phenylephrine

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7
Q

midodrine used for?

A

autonomic insufficiency and postural (orthostatic) hypotension

may exacerbate supine hypertension

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8
Q

NE used for?

A

hypotension, septic shock

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9
Q

Phenylephrine used for?

A

hypotension, ocular procedures (mydriatic), rhinitis (decongestant), ischemic priapism

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10
Q

midodrine hemodynamic changes?

A

incr. BP (vasoconstrictor), decr. HR, -/decr CO

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11
Q

NE hemodynamic changes?

A

incr. BP (vasoconstrictor), -/decr. HR (may occur reflective decr. in HR due to incr. BP due to alpha 1 agonism outweighting direct B1 chronotropic effect), -/ increased CO

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12
Q

phenylephrine hemodynamic changes?

A

incr. BP (vasoconstriction), decr. HR, -/decr. CO

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13
Q

isoproterenol receptors?

A

beta1=beta2

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14
Q

what drug acts beta1=beta2?

A

isoproterenol

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15
Q

isoproterenol used for?

A

electrophysiologic evaluation of tachyarrhytmias. can worsen ischemia

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16
Q

isoproterenol hemodynamic changes?

A

decr. BP (vasodilation), incr. HR and incr. CO

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17
Q

dobutamine receptors?

A

beta1>beta2>alpha1

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18
Q

beta1>beta2>alpha1 what drug?

A

dobutamine

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19
Q

dobutamine used for?

A

cardiac stress testing, congestive HF with cardiogenic chock (inotrope)

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20
Q

cardiac stress testing, congestive HF with cardiogenic chock (inotrope) what drug?

A

dobutamine

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21
Q

dobutamine hemodynamics?

A

-/decr. BP
incr. HR,
incr CO

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22
Q

fenoldopam receptors?

A

D1

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23
Q

D1 receptor agonist?

A

fenoldopam

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24
Q

fenoldopam elimination 1/2?

25
fenoldopam application?
postoperative hypertension, hypertensive crisis vasodilator (renal, coronary, splanchnic, peripheral) promotes natriuresis can cause hypotension and tachycardia
26
which drug promotes natriuresis?
fenoldopam
27
vasodilator (renal, coronary, splanchnic, peripheral)?
fenoldopam
28
postoperative hypertension, hypertensive crisis?
fenoldopam
29
fenoldopam hemodynamic?
decr. BP, incr. HR, incr. CO
30
dopamine receptors?
D1=D2>beta?alpha
31
D1=D2>beta1>alpha1; drug?
dopamine
32
dopamine application?
unstable bradycardia, HF, shock
33
dopamine low doses receptors?
D1
34
dopamine medium doses receptors?
beta1
35
dopamine high doses receptors?
alpha1
36
what effects on heart are due to dopamine?
inotropic and chronotropic at lower doses due to beta1
37
what effects on vessels are due to dopamine?
vasoconstriction at high doses due to alpha effects
38
dopamine hemodynamics?
incr. BP (high doses due to vasoconstriction); incr. HR, incr. CO
39
mirabegron receptor?
beta3
40
beta3 rec. drug?
mirabegron
41
mirabegron application?
urinary urgency in incontinence or overreactive bladder.
42
urinary urgency in incontinence or overreactive bladder drug?
mirabegron
43
mirabegron hemodynamic?
none
44
albuterol, salmeterol, terbutaline receptors?
beta2>beta1
45
beta2>beta1 drugs?
albuterol, salmeterol, terbutaline
46
albuterol application?
ACUTE asthma/COPD.
47
salmeterol application?
long term asthma/COPD.
48
terbutaline application?
acute bronchospasm and tocolysis (premature labor supression)
49
drug for tocolysis?
terbutaline
50
albuterol, salmeterol, terbutaline hemodynamics?
little increase in HR
51
epinephrine receptors?
beta>alpha
52
beta>alpha drug?
epinephrine
53
epinephrine application?
anaphylaxis, asthma, open-angle glaucoma; alpha predominate at high doses; stronger effect on beta2 than NE
54
anaphylaxis, asthma, open-angle glaucoma; alpha predominate at high doses drug?
epinephrine
55
epinephrine. Low dose receptors?
beta1, beta2
56
epinephrine. medium dose receptors?
beta1; beta2 and alpha1 vienas kita kompensuoja
57
epinephrine. high dose receptors?
alpha1, beta1, beta2 - alpha1 overcomes beta2 effect
58
epinephrine hemodynamics?
incr BP (high doses), incr HR, incr CO

1 STEP General pharm (UW ir FA) (7 decks)

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