disease profiles Flashcards
(56 cards)
what is sarcopenia
age related loss of muscle mass, strength and muscle quality
what are the 4 main groups of causes of sarcopenia
aging
disease
inactivity
malnutrition
name some diseases which can cause sarcopenia
inflammatory conditions
organ failure
cancer
COPD
name some causes of inactivity that can lead to sarcopenia
bed rest
hospital admission
sedentary lifestyle
name some causes of malnutrition that can lead to sarcopenia
undernourishment and malabsorption
anorexia
sarcopenic obesity
what is sarcopenic obesity
combination of high body fat and low muscle mass
pathophysiology behind sarcopenia
reduced number of motor units, and muscle fibres + increased muscle fibre atrophy
how do patients with sarcopenia present
weakness, slow walking, difficulty getting up from sitting, loss of weight and muscle mass
what is used to screen for patients with sarcopenia and what is a positive test
SARC-F questionnaire score ≥ 4
low gait speed
how can muscle strength be examined in a consultation
sit to stand in 30s
hand grip
management of sarcopenia
increase dietary protein
resistance training
name some intrinsic factors that can contribute to falls
medical conditions
cognition
impaired vision and hearing
changes in gate, reflexes and muscle strength
name some medical conditions that can increase the risk of falls
diabetes - causes nephropathy which affects proprioception + retinopathy
arthritis, parkinsons etc. alters gate
incontinence - makes pts need to get up in the night
when would we say a patients diabetic neuropathy is functionally significant
loss of heel reflex
impaired position sense at the great toe
inability to stand on one foot
name some extrinsic factors that can contribute to falls
medications: antihypertensives, psychotropic drugs, hypoglycaemic drugs
rugs, furniture etc
footwear
not using walking aids
fear of falling
name some psychotropic drugs and how they can contribute to falls
phenytoin causes cerebellar damage
antidepressants and antipsychotics (venlafaxine, duloxetine, risperidone, haloperidol) can cause orthostatic hypertension
how can fear of falling contribute to falls
cautious gait decreases walking stability
- decreases walking speed and step length
- increases time that both feet are on the ground
what is a drop attack
where a person suddenly collapses without any preceding symptoms and without apparent LOC
what is the carotid sinus
an area of dilatation in the internal carotid artery which contains a number of baroreceptors
how does the carotid sinus help maintain homeostasis
responds to increased pressure in the vessel wall
causes peripheral vasodilation and reduction in heart rate
what is carotid sinus syndrome
abnormal activation of the carotid sinus leading to symptoms secondary to cerebral hypoperfusion
who does carotid sinus syndrome tend to affect and why
older patients
increased baroreceptor sensitivity and reduced cerebral autoregulatory mechanisms
name 4 causes of orthostatic hypertension
baroreflex dysfunction
medications, volume depletion, deconditioning due to prolonged bed rest
peripheral neuropathy (DM and amyloidosis)
parkinsons and LBD (neurogenic OH)
how do we investigate drop attacks
carotid sinus massage, ECHO, cardiac monitoring