Diseases of the Respiratory System Flashcards

(92 cards)

1
Q

What viruses commonly cause coryza?

A

Rhinoviruses, coronaviruses and adenoviruses

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2
Q

What ear condition can be a complication of coryza?

A

Otitis media

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3
Q

In sinusitis, what is the treatment for someone who has had symptoms for 10 days or less?

A

Advise that acute sinusitis is usually caused by a virus it takes 2–3 weeks to resolve.

Symptoms, including fever, can be managed with self-care measures such as paracetamol or ibuprofen for pain or fever. Some people may want to consider a trial of nasal saline or nasal decongestants (although evidence is lacking to support their use)

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4
Q

In sinusitis, what is the recommendation if a person has had symptoms for around 10 days or more with no improvement?

A

Consider prescribing a high-dose nasal corticosteroid for 14 days

Reserve antibiotics for severe/deteriorating cases of >10 days duration. 1st line = penicillin V

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5
Q

What severe complications can be caused by sinusitis?

A

Intraorbital or periorbital complications - periorbital oedema/cellulitis/displaced eyeball/double vision/ophthalmoplegia/newly reduced visual acuity

Intracranial complications - swelling over the frontal bone/meningitis/severe frontal headache/focal neurological signs.

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6
Q

How is rhinitis classed by type and by timeframe?

A

Type = allergic or non-allergic

Timeframe = seasonal/intermittent or perennial/persistent

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7
Q

What is the treatment for allergic rhinitis?

A
  • Allergen avoidance
  • Nasal irrigation with saline

Mild-to-moderate intermittent, or mild persistent symptoms = intranasal antihistamines (azelastine) or oral antihistamine (loratadine or cetirizine)

Moderate-to-severe persistent symptoms = regular intranasal corticosteroid (eg fluticasone propionate or beclomethasone)

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8
Q

What is the most common viral vs bacterial cause of pharyngitis?

A

Viral - endemic adenovirus

Bacterial - Streptococcus pyogenes (Group A Beta Haemolytic Strep) aka strep throat

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9
Q

What are the complications associated with pharyngitis

hint - 1 ear, 2 throat, 1 skull

A
  • Otitis media
  • Peri-tonsillar abscess (quinsy)
  • Parapharyngeal abscess
  • Mastoiditis
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10
Q

What is acute laryngotracheobronchitis (croup)

A

A viral or bacterial infection of the larynx and/or the trachea that causes swelling and airway obstruction

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11
Q

What causes acute laryngotracheobronchitis (croup)

A

Commonly - viruses such as parainfluenza, influenza, measles, adenovirus and respiratory syncytial virus (RSV)

Rarely - bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis

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12
Q

What is the treatment for acute laryngotracheobronchitis (croup)

A

Oral dexamethasone (all) and oxygen support/nebulized adrenaline/fluids (if needed)

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13
Q

What age group is at risk of acute laryngotracheobronchitis (croup)

A

6 months- 5 years

May rarely be seen in children as old as fifteen

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14
Q

What causes acute epiglottis?

A

H. influenzae

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15
Q

What is it critical NOT to do in acute epiglottitis

A

Inspect the epiglottis until the airway is patent

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16
Q

Which type of influenza causes pandemics and which type causes localised outbreaks?

A

Influenza A = pandemics

Influenza B = localised outbreaks

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17
Q

A “cold that goes to the chest” is the colloquial way of referring to what?

A

Acute bronchitis

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18
Q

What are the common causes of acute bronchitis?

A

Strep. pneumoniae/H. influenzae infections, or in people with COPD

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19
Q

What is the treatment of acute bronchitis?

A

NO antibiotics unless there is underlying chronic lung disease (amoxicillin)

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20
Q

What is the most common cause of pneumonia?

A

Streptococcus pneumoniae - 80% of cases

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21
Q

What organism commonly causes pneumonia in COPD patients?

A

Haemophilus influenzae

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22
Q

What organism commonly causes pneumonia following an influenza infection?

A

Staphlococcus aureus

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23
Q

What organism commonly causes pneumonia that presents with a dry cough and stypical CXR findings +/- autoimmune haemolytic anaemia and erythema multiforme?

A

Mycoplasma pneumoniae

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24
Q

What organism commonly causes atypical pneumonia that often presents with hyponatraemia and lymphopenia

A

Legionella pneumophilia

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25
What organism commonly causes pneumonia in alcoholics that classically presents with bloody or yellow sputum
Klebsiella pneumoniae
26
What organism typically causes pneumonia in patients with HIV
Pneumocystis jiroveci
27
What does CURB 65 stand for?
``` C - confusion U - urea >7mmol/L R - respiratory rate >30 B - Blood pressure <90 systolic or <60 systolic 65 - 65 years or older ``` Predicts mortality in community acquired pneumonia
28
What is the antibiotic treatment for mild/moderate CAP?
Amoxicillin PO
29
What is the antibiotic treatment for mild/moderate CAP in penicillin allergic patients?
Doxycycline PO
30
What is the antibiotic treatments for severe CAP?
IV co-amoxiclav + PO doxycycline
31
What is the antibiotic treatments for severe CAP who are penicillin allergic?
IV Levofloxacin
32
What is the antibiotic treatments for severe HAP?
IV Amoxicillin + Gentamicin
33
What is the antibiotic treatments for severe HAP who are penicillin allergic?
IV Co-trimoxazole + Gentamicin
34
What are the 4 C antibiotics?
Clindamycin, cephalosporins (eg ceftriaxone), co-amoxiclav and ciprofloxacin
35
What antibiotic that starts with a C is not part of the 4C antibiotics but you keep thinking it is you dumb bitch?
Co-trimoxazole
36
What is the antibiotic treatments for non-severe HAP
PO amoxicillin
37
What is the antibiotic treatments for non-severe HAP who are penicillin allergic?
PO doxycycline
38
How long do you have to be in hospital before an infection can be diagnosed as a hospital acquired/healthcare associated infection?
48 hours
39
What 2 things is COPD comprised of
Chronic bronchitis and emphysema
40
What 2 major heart related complications are associated with COPD
Hypertension and cor pulmonale
41
What is the first line pharmacological treatment for someone with stable COPD?
A SABA (eg salbutamol) or SAMA (eg ipratropium)
42
What are the second and third line pharmacological treatments for someone with stable COPD?
2nd line = SABA or SAMA + LABA (salmeterol)+ LAMA (tiotropium) 3rd line = above + Inh. corticosteroid (eg beclometasone)
43
What does iSOAP in an acute exacerbation of COPD stand for?
``` I - ipratropium (nebulised) S - salbutamol (nebulised) O- Oxygen A - antibiotics (amox or doxy) P - prednisolone (PO) ```
44
What ranges of PEFR are classified as moderate, severe and life threatening in asthma?
- Mod = <80% - Severe = <50% - Life-threatening = <30%
45
What does FEV1 stand for?
Forced expiratory volume in 1s - the volume exhaled in the first second after deep inspiration and forced expiration
46
What does FEV stand for?
Forced vital capacity – the total volume of air that the patient can forcibly exhale in one breath
47
What would an obstructive pattern (eg COPD/asthma etc) show on spirometry?
- FEV1 reduced - FVC normal/reduced to a lesser extent - FEV1/FVC ratio reduced
48
What would a restrictive pattern (eg pulmonary fibrosis/pulmonary oedema etc) show on spirometry?
- FEV1 reduced - FVC - FEV1/FVC ratio normal
49
What is the first line treatment for asthma?
SABA inhaler (eg salbutamol)
50
What is added to asthma treatment if a SABA does not provide adequate control
Inhaled corticosteroid (eg beclometasone)
51
What scale is used to in the diagnosis sleep apnoea?
Epworth Sleepiness Scale
52
What is the most common cause of bronchiectasis?
CF
53
In which gene is there a defect in CF?
CFTR
54
What are the 4 main causes of haemoptysis?
- Cancer - PE - Infection eg TB, bronchitis, pneumonia etc - CF
55
What GI issue prompts the diagnosis a large percentage of CF infants
Meconium ileus (SI obstruction)
56
What type of granulomas are seen in TB
Caseating granulomas
57
What stain is used in the diagnosis of TB?
ZN stain
58
What are the 2 main drugs in the treatment of TB?
Rifampicin and isoniazide
59
What type of granulomas are present in sarcoidosis?
Non-caseating granulomas
60
What type of hypersensitivity is sarcoidosis?
Type 4
61
What is the treatment for sarcoidosis?
Corticosteroids (oral prednisolone)
62
What relatively rare condition should a nasal mucosa ulcer combined with other resp symptoms make you think of
Granulomatosis with polyangiitis (Wegener's)
63
What condition with respiratory symptoms can cause s necrotising microvascular glomerulonephritis?
Granulomatosis with polyangiitis (Wegener's)
64
A high eosinophil count combined with respiratory and systemic vasculitis (fever, sweats, fatigue, weight loss, rash) symptoms should make you suspicious of what condition?
Eosinophilic Granulomatosis with Polyangiitis (EGPA/Churg-Strauss)
65
What is the treatment for granulomatosis with polyangiitis (Wegener's)
Cyclophosphamide
66
What is the treatment for eosinophilic granulomatosis with polyangiitis (EGPA/Churg-Strauss)
Corticosteroids
67
What type of ANCA does GPA show
cANCA
68
What type of ANCA does EGPA show
pANCA
69
What type of hypersensitivity is lupus?
Type 3
70
What features in a cxr would indicate idiopathic pulmonary fibrosis?
Patchy scarring of lung with collagen deposition and ground-glass/honeycombing
71
What is extrinsic allergic alveolitis (hypersensitivity pneumonitis)?
Widespread diffuse inflammatory reaction in small airways and alveoli due to inhalation of foreign antigens
72
What type of hypersensitivity is extrinsic allergic alveolitis (hypersensitivity pneumonitis)?
Type 3
73
What are the classic features of extrinsic allergic alveolitis (hypersensitivity pneumonitis) on imaging?
- CXR = fluffy upper zone nodular shadows | - CT = ground glass opacity
74
What kind of crackles are heard in extrinsic allergic alveolitis (hypersensitivity pneumonitis)?
Coarse end-inspiratory crackles
75
Where should you needle aspirate in pnemothorax?
2nd IC space, midclavicular line
76
Where should a chest drain be placed?
5th intercostal space in the mid-axillary line
77
What is empyema usually a complication of?
Pneumonia
78
What is a transudate?
Transudate = pleural effusions that are caused by factors that alter hydrostatic pressure, pleural permeability, and oncotic pressure Eg Congestive heart failure, liver cirrhosis etc
79
What is an exudate
Exudate = pleurql effusions caused by changes to the local factors that influence the formation and absorption of pleural fluid eg Malignancy, infection etc
80
What is the difference between a transudate and an exudate
Transudate = Pprotein <30 g/L Exudate= protein >30 g/L
81
What is the difference between type 1 and type 2 respiratory failure?
Typw 1 = hypoxia with normal or low PaCO2 Type 2 = hypoxia + hypercapnia
82
Give some examples of direct and indirect causes of ARDS
Direct = pneumonia, aspiration, inhalational lung injury, chest trauma, and near-drowning Indirect causes = sepsis, shock, pancreatitis, trauma
83
What kind of crackles are heard in ARDS?
Fine bilateral crackles
84
What is the definition of cor pulmomale?
Cor pulmonale = right heart failure due to pulmonary hypertension. Can occur in advanced COPD: alveolar collapse (emphysema) results in hypoxia which causes vasoconstriction, increasing pressure in the right side of the heart
85
What signs on a cardiac examination would point to cor pulmonale?
Ankle oedema, elevated JVP, parasternal heave and tricuspid regurgitation
86
What is Virchow's triad?
Virchow’s triad = endothelial damage, abnormal blood flow or hypercoagulable blood
87
What is the most common type of lung cancer?
Bronchial carcinoma / squamous cell carcinoma
88
What nerve might be affected in a lung cancer causing hoarseness?
Recurrent laryngeal nerve
89
Invasion of which nerve in lung cancer can cause dysphagia?
Phrenic nerve
90
What hormone does small cell carcinoma produce?
ACTH
91
What lung cancer is common in non-smokers?
Adenocarcinoma
92
Which type of lung cancer is chemotherapy effective against?
Small cell lung cancer