Disorder Drug Targets

Question 1

NEURO: Alzheimer’s

Answer 1

Path: - Ach-M & + Glu excitotoxicity
Pharm: + Ach-M & - Glu excitotoxicity

Question 2

NEURO: Acute-Chronic Pain

Answer 2

Path: Abnormal PG, ion channels, 5HT, Glu; + sensitization in pain pathways
Pharm: + ENK activity (+ NE-5HT), - PG formation

Question 3

NEURO: Parkinson’s

Answer 3

Path: - in striatal DA release –> + Ach –> + GABA inhib
Pharm: + DA activity, - Ach activity

Question 4

NEURO: Seizure Disorders

Answer 4

Path: abnormal VSSC (Na+), VSCC (Ca2+), - GABA and/or + Glu activity
Pharm + GABA activity, block VSSC & VSCC

Question 5

PSYCH: Psychoses

Answer 5

Path: + limbic DA, - PFC DA
Pharm: Block D2 and 5HT receptors

Question 6

PSYCH: Depression

Answer 6

Path: - 5HT-NE
Pharm: + synaptic 5HT, NE (and DA)

Question 7

PSYCH: Mania

Answer 7

Path: + NE-DA activity
Pharm: Modulate NT activity, block VSSC-VSCC

Question 8

PSYCH: Anxiety

Answer 8

Path: - 5HT-GABA or + NE
Pharm: Enhance 5HT and GABA activity

Question 9

CLIN: ADHD

Answer 9

Path: Deficient DA-NE
Pharm: + DA (D1)-NE (a2) activity

Question 10

CLIN: Insomnia

Answer 10

Path: deificient inhibitory GABA
Pharm: + GABA activity, - ACh and histamine activity

Question 11

CLIN: General Anesthesia

Answer 11

Path: No path!
Pharm: + GABAa activity, - NMDA-R fxn