Disorders Flashcards
(39 cards)
Iodine deficiency: hormone levels and manifestation
increased TSH
decreased T3/T4
goiter
Adult onset hypothyroidism (early and untreated): hormone levels and manifestation
Early: increased TSH, normal T3/T4
Untreated: increased TSH, gradual dec. in T3/T4
goiter from lymphocytic obstruction and fibrosis
Graves disease: hormone levels and manifestation
decreased TSH
increased T3/T4
goiter from TSI (antibody stimulation)
Cushing’s syndrome definition/description
primary adrenal hyperplasia
Cushing’s syndrome hormone levels
decreased ACTH
decreased glucocorticoids
decreased androgens
Cushing’s syndrome manifestation
hyperglycemia, increased proteolysis, thin skin, muscle wasting, central obesity, round face, buffalo hump, hypertension, virilization
Cushing’s disease definition/description
overactive anterior pituitary
Cushing’s disease hormone levels
increased ACTH
increased glucocorticoids
increased androgens
Cushing’s disease manifestation
hyperglycemia, increased proteolysis, thin skin, muscle wasting, central obesity, round face, buffalo hump, hypertension, virilization
Addison’s disease definition/description
primary adrenocortical insufficiency from autoimmune destruction of adrenal gland
Addison’s disease hormone levels
autoimmune destruction of gland leads to: decreased mineralocorticoids decreased glucocorticoids decreased androgens (all cortical hormones)
Secondary Adrenocortical Insufficiency: hormone levles
↓ CRH or decreased ACTH
normal aldosterone
↓ glucocorticoids
↓ androgens
Secondary Adrenocortical Insufficiency symptoms
symptoms related to
↓ cortisol: hypoglycemia during stress, anorexia, wt loss, weakness
↓ androgens: in females loss of pubes and armpit hair, decreased libido
Addison’s disease symptoms
↓cortisol: hypoglycemia during stress, anorexia, wt loss, weakness
↓aldo: hyperK, hypotension, metabolic acidosis, salt craving
↓androgens: in females loss of pubes and armpit hair, decreased libido
Conn’s Syndrome: what is it?
an aldosterone secreting tumor
Conn’s syndrome: hormone levels
low renin levels
increased mineralcorticoids
Conn’s syndrome: symptoms
Hypernatremia, fluid retention, HTN
Hypokalemia
Metabolic alkalosis
Androgenital syndrome: what is going on here? what are the hormone levels like?
hypersecretion of adrenal androgens; as such…
↑ androgens
Androgenital syndrome manifestation
Masculinizing condition in females
Adult females develop male traits: deep voice, increased muscle mass, amenorrhea, hirsutism, clitoral enlargement, acne
21 B-hydroxylase deficiency: hormone levels
↑ ACTH levels – lack of feedback control of cortisol)
NO mineral corticoids
NO glucocorticoids
increased Androgens
21 B-hydroxylase deficiency manifestation
leads to androgenital syndrome
enlarged adrenal gland
17 alpha-hydroxylase deficiency: hormone levels
↑ Mineralcorticoids (↓ Aldo because of symptoms of corticosterone excess HTN inhibits renin secretion)
NO mineralcorticoids
NO androgens
17 alpha-hydroxylase deficiency: manifestations
hypertension (which inhibits renin secretion)
Rickets definition & cause
vitamin D deficiency of childhood caused by inadequate diet and/or sunlight exposure
