Disorders of cardiac function Flashcards

(50 cards)

1
Q

Pericarditis & and causes

A

inflammation of the pericardium (the membrane enclosing the heart)
Acute =

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2
Q

Pericarditis manifestations

A
Decreased CO
Pericardial friction rub
Chest pain
Precordial
Abrupt onset, sharp, radiates
Scapula pain
increases with deep breath, cough
relief when sitting forward

ECG changes

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3
Q

Pericardial Effusion

A
Accumulation of fluid in the pericardial cavity/space
Causes
- Inflammation of pericardium
- Infection elsewhere
- Neoplasms
- Cardiac surgery
- Trauma 
Symptoms dependent on rapidiy & amount of fluid build-up
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4
Q

Cardiac Tamponade & causes

A

Compression d/t fluid/blood
A build-up of blood or other fluid in the pericardial sac puts pressure on the heart, which may prevent it from pumping effectively.

Causes:
Trauma
Myocardial rupture post MI
Cardiac surgery
Aortic dissection
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5
Q

Tamponade: Manifestations

A

Dependent on amount and rapidity

Limits stroke volume and CO = low SBP
CNS: change in mentation
Resp: dyspnea, tachypnea
CVS: chest pain, tachycardia

  • Elevated central venous pressure & jugular venous pressure (distention)
  • Circulatory shock
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6
Q

Tamponade: Diagnosis/Treatment

A
Muffled heart sounds- d/t to extra layer of fluid
Pulsus paradoxus
> 10 mmHg fall with respiration
ECG
- Decreased voltage
Echocardiogram
CT, MRI
Treatment: immediate pericariocentesis
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7
Q

What assists coronary artery flow?

A
  • Endothelial cells lining arteries
    -Diastolic pressure in aorta
    Time in diastole
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8
Q

What impairs coronary artery flow?

A

Atherosclerosis most common

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9
Q

Non-Modifiable Risks for CAD

A
Sex/Gender
Post-menopausal women
Age
Ethnicity
Genetics
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10
Q

Modifiable Risks for CAD

A
  1. Hypertension
  2. Hyperlipidemia
  3. Tobacco use
  4. Diabetes
  5. Obesity
  6. Sedentary lifestyle/physical inactivity
  7. Ability to cope with stress
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11
Q

Stable Angina

A
  • Pain/pressure d/t transient ischemia
  • Precordial/substernal
  • Possible radiation
  • Possible epigastric discomfort
  • Often d/t a fixed coronary narrowing
  • Occurs with exercise/exertion/cold/emotions
  • Relieved with rest & nitroglycerine

Artery in the heart is partially blocked, so not getting enough O2.

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12
Q

Variant/Prinzmetal Angina

A

d/t spasms of coronary artery
Cause is unclear
Often @ night
Variable symptoms

Treatment is dependent on findings of investigative diagnostics

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13
Q

Silent MI

A

Silent MI’s (or atypical symptoms) are more likely in the elderly
? Less myocardium involved
? neuropathy
- hypotension, low body temp, vague complaints of discomfort, mild diaphoresis, stroke-like symptoms, dizziness, sensorium changes

Treatment is dependent on findings of investigative diagnostics

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14
Q

Acute Coronary Syndrome

A

Risk is classified based on ECG changes
Unstable Angina/Non ST-segment elevation Myocardial Infarction (non-STEMI)
ST-segment elevation MI (STEMI) - ischemia to heart muscle

All caused by an imbalance in myocardial          
oxygen supply and demand
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15
Q

Potential Causes of ACS: Primary & Secondary Causes

A

> Unstable plaque, rupturing to form a clot
- Thin fibrous cap with fatty core is most unstable
Coronary vasospasm
Atherosclerotic narrowing (progressive)
Inflammation/infection
Secondary causes
- anemia
- fever (basal metabolic rate is high)
- hypoxemia

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16
Q

Unstable Angina/Non-ST MI

A
Typical Pattern of Manifestations
> With pre-diagnosis of “Stable Angina”
- But more severe or more often than usual
> Occurs at rest (or minimal exertion)
> Lasts > 20 minutes

If biomarkers are elevated = non-STEMI
High risk of STEMI

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17
Q

ST Elevation MI

A

Ischemic death of myocardial tissue

> Typical Pattern of Manifestations
Crushing/constricting pain; usually abrupt
- Substernal with radiation to left arm, jaw, neck

  • Epigastric distress/nausea
  • Palpitations
  • Cool, clammy skin
  • SOB
  • Anxiety

Unrelieved by rest/nitro

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18
Q

ST Elevation MI Con’t…

A

Cardiac muscle wall ischemia & necrosis

  • Subendocardial
  • Transmural = Q wave
  • “Stunned” myocardium

Cell death in 15-20 minutes

Early perfusion & revascularization can prevent necrosis.

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19
Q

Myocardial Ischemia/Necrosis result in…

A

Decreased contractile force

  • Decreased CO
  • Decreased coronary artery perfusion
  • Decreased pulmonary vasculature pressure

Interruption of conduction
- dysrhythmias

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20
Q

Diagnosis of myocardial ischemia also based on Serum Biomarkers

A

> Troponin (involved in muscle contraction)
Rises within 2-3 hrs; remains elevated for 7-10 days

> Myoglobin (functions as oxygen storage)
Rises within 1 hr, peaks at 4 hrs
Also from skeletal muscle damage

> Creatine Kinase MB (CK-MB) (levels can indicate muscular dystrophy)
Peaks at 4-6 hrs; gone in 2-3 days
Specific to cardiac muscle

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21
Q

Acute MI Treatment

A
Oxygen
Pain relief
Reperfusion
- Fibrionolytics
- Percutaneous transluminal coronary angioplasty (PTCA)
- Stents

Coronary Artery Bypass Grafting (CABG)- taking a vein from another part of the body and using it in the heart

22
Q

Complication of an Acute MI

A
  • Arrhythmias – most common cause of sudden death
  • Reinfarction
  • Heart failure
  • Pericarditis
  • Embolic CVA or Pulmonary embolus
  • Valve deformities
  • Septal rupture
  • LV wall aneurysms/rupture
  • Cardiogenic shock
  • Dressler syndrome
23
Q

Cardiomyopathies

A
Cardio = heart
Myo = muscle
Pathy = disorder/syndrome/bad
“Idiopathic cardiomyopathy”
Muscle disorders
Mechanical (eg: heart failure)
Electrical (eg: arrhythmias)
Primary 
Secondary
24
Q

Hypertrophic Cardiomyopathy (HCM)

A

Leading cause of sudden cardiac death in young adults

Unexplained genetic ventricular septal thickening
Poor diastolic finding
LV outflow obstruction
Left ventricular hypertrophy (LVH)
Disruption of normal conduction pathways
25
Hypertrophic Cardiomyopathy (HCM) Manifestations
``` > Variable > Decreased stroke volume d/t impaired diastolic filling - Dyspnea - Chest pain - Syncope post exertion ``` > Atrial fibrillation > Lethal ventricular arrhythmias
26
Endocarditis & and Risk factors
Any infection of inner lining of heart - Usually staphylococcus aureus - Vegetative (growth) - Involvement of mitral & aortic valves most common - Acute: relatively healthy individual - Sub-acute/chronic: h/o valve abnormalities ``` Risk Factors Infection elsewhere Dental surgery/surgery, IV drug use/contaminants Immunodeficiency/immunosuppression Valve prolapse (sudden or congenital) ```
27
Endocarditis manifestations & complications
> Manifestations S&S of systemic infection Heart sound changes Symptoms related to embolism > Complications Emboli (lung, renal, brain, etc.) Valve dysfunction arrhythmias
28
Rheumatic Heart Disease
> Caused by rheumatic fever - Which occurs after streptococcal pharyngitis - Sore throat, h/a, fever, n&v, joint pain - One or all layers (pancarditis) - valves - Aschoff bodies > Immunological response but pathogenesis unclear > Acute, chronic, or recurrent
29
Rheumatic Heart Disease diagnosis and treatment
> Acute phase = pancarditis - Pericardial friction rub, murmur - Mitral/aortic valve involvement - Arrhythmias > Diagnosis - Evidence of GAS infection - Elevated WBC, ESR, CRP - Echocardiogram, Ultrasound > Treatment Antibiotics, prevention of complications
30
Valvular Disorders causes
``` Congenital Trauma Ischemic damage Degenerative changes Inflammation ```
31
Valvular Disorders treatment
``` Preventative APA (antiplatelet aggregator) Symptoms Percutaneous valvuloplasty Surgery ```
32
Valvular Disorders Diagnosis
Auscultation Doppler Echo ultrasound
33
When Will You Hear Murmurs?
- If a valve is stenotic, you will hear a murmur of blood shooting through the narrow opening when the valve is open - If a valve is regurgitant, you will hear a murmur of blood leaking back through when the valve should be closed
34
Mitral Valve Stenosis
``` Fibrous, stiff tissue, often causing chordae tendineae to shorten Incomplete opening obstructs blood flow Causes RF Congenital ```
35
Mitral Valve Stenosis manifestations & complications
Manifestations -Chest pain, weakness, fatigue, palpitations Complications - Arrhythmias (atrial fibrillation, atrial tachycardias) - Mural thrombi
36
Mitral Valve Regurgitation (MVR) & causes
> Incomplete closing - Some blood returns to LA during systole > Causes - RDH - Chordae tendineae or papillary muscle rupture - LVH dilates orifice - Mitral valve prolapse
37
Mitral Valve Regurgitation manifestations and complications
Manifestations - Slow process = compensation - Pulmonary congestion - Pansystolic murmur - LA Atrial and LV hypertrophy Complications - Atrial fib - thrombus
38
Mitral Valve Prolapse manifestations and complications
> Leaflets enlarge, become “floppy” Associated with: Marfan’s sydrome & Osteogensis imperfecta ``` Manifestations “snap” Asymptomatic Chest pain, dyspnea, etc. Complications MVR, a. fib thrombus ```
39
Aortic Valve Stenosis causes and manifestations
``` Narrowing causing resistance to ejection Slow progression = compensation Causes: Congenital or acquired Male, active inflammation ``` Manifestations Loud systolic ejection murmur or split S2 Chest pain, dyspnea, syncope, heart failure (LV hypertrophy)
40
Aortic Valve Regurgitation & causes
Scarring of leaflet and/or enlarged orifice Blood flow back into LV during diastole Causes RHD, ideopathic aortic dilation, congenital, endocarditis, Marfan’s, HPTN, trauma
41
Chronic Aortic Regurgitation
- Slow progression = compensation - LV enlarges but works harder Manifestations - Blowing sound over valve - Widening pulse pressure - Korotkoff sounds persist to zero! - Tachycardia, water-hammer pulse - “pounding” of heart when lying down - Eventually orthopnea, dyspnea, paroxysmal nocturnal dyspnea
42
Acute Aortic Regurgitation causes & manifestations
> Causes Acute endocarditis Trauma Aortic dissection ``` > Manifestations Too quick for compensation! Extreme rise in LVEDP = pulmonary edema - Decreased coronary artery perfusion Dysrhythmias = lethal ```
43
Patent Ductus Arteriosus
Persistent delay > 3 months Normally closes @ 24-72hrs Delay if premature Manifestations Dependent on size High pressure from aorta = pulmonary hypertension
44
Atrial Septal Defects
Non-closure of foramen ovale Often asymptomatic until teenage Manifestations Increased pulmonary pressures Atrial dilatation = dysrhythmias
45
Ventricular Septal Defects cause and manifestations
Most common congenital heart defect (25-30% of all) Cause: Incomplete separation of ventricles during development invitro 1/3 close spontaneously Manifestations dependent on size Asymptomatic heart failure Tachypnea, tachycardia, pulmonary congestion, failure to thrive
46
Pulmonary Stenosis
``` Obstruction of blood flow from RV Causes Pulmonary valve lesions Pulmonary artery lesions Combination ``` 10% of all congenital cardiac disease Often associated with other patho
47
Tetralogy of Fallot
Most common cyanotic congenital heart defect (5-7% of all) ``` Pulmonic narrowing RV hypertrophy Ventricular septal defect Dextroposition of aorta Over-rides RV, attaches to septal defect ```
48
Tetralogy of Falot manifestations and treatment
Manifestations Cyanosis with increased oxygen demands Crying, feeding, defecation Loss of consciousness possible Treatment Knee-chest position Surgery
49
Transposition of the Great Arteries
``` RV empties into aorta LV empties into pulmonary arteries Risk Factors Mothers with diabetes Boys > girls Manifestations Cyanosis Survival if patent ductus arteriosus or septal defect ```
50
Coarctation of the Aorta
Associated with other congenital lesions ``` Manifestations BP lower in legs than in arms Asymptomatic Hypertension later in life LVH ```