Disorders of haemostasis Flashcards
(20 cards)
Primary or Secondary? Acquired FVIII deficiency
Secondary
Primary or Secondary? Decompensated cirrhosis of the liver?
Secondary
Primary or Secondary? DIC
BOTH!
Primary or Secondary? ITP (immune thrombocytopenic purpura)
Primary
Primary or Secondary? Heparin treatment
Secondary
Primary or Secondary? Thrombo-asthenia
Primary
Primary or Secondary? Haemophilia
Secondary
Primary or Secondary? Vitamin K deficiency
Secondary
Primary or Secondary? Von Willebrand’s Disease
Primary
Primary or Secondary? Warfarin treatment
Secondary
Features of acquired FVIII deficiency
Antibodies against FVIII
PT and platelet count normal
APTT prolongued
Features of DIC
SIRS, sepsis leading to DIC:
Prolongued everything, low fibrinogen
Features of ITP
Purpura Mucousal bleeding Antibodies against platelets... Low platelet count Normal PT, APTT, TT, fibrinogen, but prolonged bleeding time
Features of heparin treatment
Increase APTT (therapeutic levels 1.5-2.5 times normal APTT)
Features of thrombo-asthenia
Inherited disorder of platelets - specifically GPIIb-IIIa
Prevents binding of platelets to each other (normally GPIIb-IIIa binds with vWF and fibrinogen)
Features of Haemophilia A
Factor VIII deficiency
Prolonged APTT - reduced FVIII
Features of Haemophilia B
Factor IX deficiency
Prolonged APTT - reduced FIX
Features of Vitamin K deficiency
Vit K dependant factors: II, VII, IX, X
Features of vW disease
Defective vW factor
- Quantitative (most common)
- Qualitative
Prolonged bleeding time and APTT
Features of Warfarin treatment
Prolonged PT
Overdose - prolonged APTT
