Disorders Of Haemostasis

Question 1

What are the elements of a significant bleeding history

Answer 1

Slide 7

Question 2

Abnormal haemostasis can be caused by…?

Answer 2

Slide 10

Question 3

Disoders of primar haemostasis

Answer 3

Slide 25

Question 4

Platelet disorders

Answer 4

Slide 20

Question 5

ITP is a very commoncause of thrombocytopenia

Answer 5

CLOZE

Slide 16

Question 6

What are the mechanisms and causes of thrombocytopenia?

Answer 6

Slide 17

Question 7

Give 3 examples of hereditary platelet defects

Answer 7

Slide 19

Question 8

Von Willebrand factor disorders

Answer 8

Often hereditary - most common bleeding disorder autosomal
Slide 21-22
Type 1 - not enough, but some
Type 2 - not working properly
Type 3 - not at all, recessive

Question 9

What are the two main fuctions of VWF in haemostasis?

Answer 9

Slide 22

Question 10

Vessel wall disorders

Answer 10

Slide 24

Question 11

What is the bleeding like in disorders of primary haemostasis?

Answer 11

Slide 28

Question 12

What are the tests for disorders of primary haemostasis?

Answer 12

Slide 30

Question 13

Deficiency of any coagulatino factor results in a failure of thrombin generation and hence fibrin formation

Answer 13

CLOZE

Question 14

TRUE OR FALSE:

A primary platelet plug is sufficient for all vessel injuries

Answer 14

False

SLIDE 35

Question 15

What is haemophilia?

Answer 15

Failure to generate fibrin to stabilise platelet plug

Question 16

What are the disorders of coagulation?

Answer 16

Slide 43

Question 17

TRUEOR FALSE:

Coagulation factor deficiencies are not all the same

Answer 17

TRUE

Slide 40

Question 18

Acquired coagulation disorders are more common in…?

Answer 18

Hospital practice
Slide 42

NOTE: much more common than haemophilia

Question 19

What happens in ncreased consumption (disorder f coagulation)

Answer 19

Slide 44
DIC = seen with sepsis, amaor tissue damage, cancerUnregulated turning on of coagulation system - starts using all coagulation factors

Question 20

What is bleeding like in coagulation disorders?

Answer 20

Slide 45

Question 21

Describe the clinical distinction between bleeding due to platelelt and coagulation defects

Answer 21

Slide 49

Question 22

Haemarthrosis is the hallmark of haemophilia

Answer 22

CLOZE

Question 23

What are the tests for coagulation disorders?

Answer 23

Slide 50

APTT = factors XII, Xi, VIII, IX, V, X, II
PT = factors VIIa, V, X, II
Slide 51

Question 24

Give examples of clotting disorders that are not detected by routine clotting tests

Answer 24

Slide 52

Question 25

What are the different disorders of fibrinolysis?

Answer 25

Slide 54

Question 26

What are the genetics of haemophilia?

Answer 26

Sex linked recessive (SLR)

Question 27

What are the genetics of Von Willebrand disease?

Answer 27

Autosomal | Slide 58

Question 28

Apart from haemophilia and Von Willebrand disease, bleeding disorders are autosomal recessive (AR) - and therefore much less common

Answer 28

CLOZE

Question 29

Outline the treatment of abnormal haemostasis

Answer 29

Slide 60

Question 30

What are the principles of treatment of haemostatic disorders causing bleeding?

Answer 30

Slide 61

Question 31

How does desmopressin (DDAVP) work as a haemostatic treatment

Answer 31

Slide 63

Question 32

How does tranexamic acid work as a haemostatic treatment?

Answer 32

Slide 64