Distribution Flashcards
(115 cards)
1
Q
highly protein bounded drugs
A
diazepam, digoxin
indomethacin, tolbutamide
warfarin, midazolam
2
Q
Vd: chloroquine
A
high
3
Q
Vd: atropine
A
high
4
Q
Vd: digoxin
A
high
5
Q
Vd: fluoxetine
A
high
6
Q
Vd: imipramine (TCAs)
A
high
7
Q
Vd: beta blockers
A
high
8
Q
Vd: chlorpropamide
A
low
9
Q
Vd: furosemide
A
low
10
Q
Vd: tolbutamide
A
low
11
Q
Vd: warfarin
A
low
12
Q
Vd: valproic acid
A
low
13
Q
CYP: theophylline
A
CYP1A2
14
Q
CYP: caffeine
A
CYP1A2
15
Q
CYP: duloxetine
A
CYP1A2
16
Q
CYP: melatonin
A
CYP1A2
17
Q
CYP: clozapine
A
CYP1A2
18
Q
CYP: ramosetron
A
CYP1A2
19
Q
CYP: cyclophosphamide
A
CYP2B6
20
Q
CYP: ifosfamide
A
CYP2B6
21
Q
CYP: bupropion
A
CYP2B6
22
Q
CYP: efavirenz
A
CYP2B6
23
Q
CYP: repaglinide
A
CYP2C8
24
Q
CYP: montelukast
A
CYP2C8
25
CYP: pioglitazone
CYP2C8
26
CYP: celecoxib
CYP2C9
27
CYP: phenytoin
CYP2C9
28
CYP: 2nd gen sulfonylureas
CYP2C9
29
CYP: tolbutamide
CYP2C9
30
CYP: S-warfarin
CYP2C9
31
CYP: omeprazole
CYP2C19
32
CYP: lansoprazole
CYP2C19
33
CYP: rabeprazole
CYP2C19
34
CYP: diazepam
CYP2C19
CYP3A4
35
CYP: voriconazole
CYP2C19
36
CYP: s-mephenytoin
CYP2C19
37
CYP: desipramine
CYP2D6
38
CYP: dextrometorphan
CYP2D6
39
CYP: eliglustat
CYP2D6
40
CYP: nebivolol
CYP2D6
41
CYP: nortriptyline
CYP2D6
42
CYP: perphenazine
CYP2D6
43
CYP: tolterodine
CYP2D6
44
CYP: venlafaxine
CYP2D6
45
CYP: amitriptyline
CYP2D6
46
CYP: encainide
CYP2D6
47
CYP: imipramine
CYP2D6
48
CYP: metoprolol
CYP2D6
49
CYP: propafenone
CYP2D6
50
CYP: propranolol
CYP2D6
51
CYP: tramadol
CYP2D6
52
CYP: trimipramine
CYP2D6
53
CYP: macrolides
CYP3A4
54
CYP: amiodarone
CYP3A4
55
CYP: cortisol
CYP3A4
56
CYP: grapefruit juice
CYP3A4
57
metabolic phase: chloramphenicol
Phase I: reduction
(nitro reduction)
58
metabolic phase: naloxone
Phase I: reduction
(carbonyl reduction)
59
metabolic phase: methadone
Phase I: reduction
(carbonyl reduction)
60
metabolic phase: prontosil
Phase I: reduction
(azo reduction)
61
metabolic phase: procaine
Phase I: hydrolysis
(esters)
62
metabolic phase: aspirin
Phase I: hydrolysis
(esters)
63
metabolic phase: enalapril
prodrug
Phase I: hydrolysis
(esters)
64
metabolic phase: cocaine
metabolite: benzoic acid
Phase I: hydrolysis
(esters)
65
metabolic phase: lidocaine
Phase I: hydrolysis
(amide)
66
metabolic phase: indomethacin
Phase I: hydrolysis
(amide)
67
metabolic phase: procainamide
Phase I: hydrolysis
(amide)
68
metabolic phase: acetaminophen
Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase
69
metabolic phase: diazepam
Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase
70
metabolic phase: chloramphenicol
Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase
71
metabolic phase: digoxin
Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase
72
metabolic phase: morphine
Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase
73
metabolic phase: isoniazid
Phase II: acetylation
enzyme: NAT1 and NAT2
74
metabolic phase: hydralazine
Phase II: acetylation
enzyme: NAT1 and NAT2
75
metabolic phase: procainamide
Phase II: acetylation
enzyme: NAT1 and NAT2
76
metabolic phase: streptomycin
Phase II: acetylation
enzyme: NAT1 and NAT2
77
metabolic phase: nicotinic acid
Phase II: glycine conjugation
78
metabolic phase: ethacrynic acid
Phase II: glutathione conjugation
79
metabolic phase: dopamine
Phase II: methylation
80
metabolic phase: epinephrine
Phase II: glycine conjugation
81
enzyme ind/inh:
broccoli
enzyme inducer (CYP1A2)
82
enzyme ind/inh:
brussel sprouts
enzyme inducer (CYP1A2)
83
enzyme ind/inh:
char-grilled meat
enzyme inducer (CYP1A2)
84
enzyme ind/inh:
benzo-a-pyrene
enzyme inducer (CYP1A2)
85
enzyme ind/inh:
ompeprazole
enzyme inducer (CYP1A2)
86
enzyme ind/inh:
tobacco
enzyme inducer (CYP1A2)
87
enzyme ind/inh:
rifampin
enzyme inducer (CYP2C9, 2C19, 2D6, 3A4)
88
enzyme ind/inh:
dexamethasone
enzyme inducer (CYP2D6)
89
enzyme ind/inh:
phenobarbital
enzyme inducer (CYP3A4)
90
enzyme ind/inh:
st. john's wort
enzyme inducer (CYP3A4)
91
enzyme ind/inh:
carbamazepine
enzyme inducer (CYP3A4)
92
enzyme ind/inh:
glucocorticoids
enzyme inducer (CYP3A4)
93
enzyme ind/inh:
fluvoxamine
enzyme inhibitor (CYP1A2)
94
enzyme ind/inh:
ciprofloxacin
enzyme inhibitor (CYP1A2)
95
enzyme ind/inh:
fluconazole
enzyme inhibitor (CYP2C9)
96
enzyme ind/inh:
amiodarone
enzyme inhibitor (CYP2C9)
97
enzyme ind/inh:
PPI (except pantoprazole)
enzyme inhibitor (CYP2C19)
inhibits clopidogrel activation
98
enzyme ind/inh:
fluoxetine
enzyme inhibitor (CYP2D6)
99
enzyme ind/inh:
paroxetine
enzyme inhibitor (CYP2D6)
100
enzyme ind/inh:
quinidine
enzyme inhibitor (CYP2D6)
101
enzyme ind/inh:
duloxetine
enzyme inhibitor (CYP2D6)
102
enzyme ind/inh:
terbinafine
enzyme inhibitor (CYP2D6)
103
enzyme ind/inh:
indinavir
enzyme inhibitor (CYP3A4)
104
enzyme ind/inh:
nelfinavir
enzyme inhibitor (CYP3A4)
105
enzyme ind/inh:
ritonavir
enzyme inhibitor (CYP3A4)
106
enzyme ind/inh:
clarithromycin
enzyme inhibitor (CYP3A4)
107
enzyme ind/inh:
itraconazole
enzyme inhibitor (CYP3A4)
108
enzyme ind/inh:
ketoconazole
enzyme inhibitor (CYP3A4)
109
enzyme ind/inh:
nefazodone
enzyme inhibitor (CYP3A4)
110
enzyme ind/inh:
saquinavir
enzyme inhibitor (CYP3A4)
111
enzyme ind/inh:
telithromycin
enzyme inhibitor (CYP3A4)
112
enzyme ind/inh:
aprepitant
enzyme inhibitor (CYP3A4)
113
enzyme ind/inh:
erythromycin
enzyme inhibitor (CYP3A4)
114
enzyme ind/inh:
fluconazole
enzyme inhibitor (CYP3A4)
115
enzyme ind/inh:
grapefruit juice
enzyme inhibitor (CYP3A4)
