Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Step 1 > DIT primers: Biochem > Flashcards

DIT primers: Biochem Flashcards

(44 cards)

Start Studying
1
Q

antibiotic: Teeth discoloration

A

Tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antibiotic: Tendonitis

A

Fluoroquinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antibiotic: Red man Syndrome

A

Vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antibiotic: Gray baby syndrome

A

Chloramphenicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antibiotic: Cartilage damage in children

A

Fluoroquinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antibiotic: Nephrotoxicity, ototoxicity

A

aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antibiotic: Psuedomembranous colitis

A

Clindamycin, ampicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which structures form the Hasselback triangle?

A

Top: Inferior epigastric artery
Medial: rectus Abdominus muscle
Lateral: inguinal Ligament

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pathway, location and source of nitrogen for Carbamoul phosphate synthetase 1 (CPS-1)?

A
  • Urea pathway
  • Mitochondria
  • Ammonia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Pathway, location and source of nitrogen for Carbamoul phosphate synthetase 2 (CPS-2)?

A
  • Pyrimidine synthesis pathway
  • Cytosol
  • Glutamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Lesch-Nyhan Syndrome is a deficiency in what enzyme

A
  • HGPRT (hypoxanthine Guanine Phosphorribosyltransferase)

- converts hypoxanthine to IMP and Guanine to GMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

key features of Lesch-Nyhan Syndrome

A
  • Gout (hyperuricemia)
  • Intellectual disability
  • aggressive behavior
  • Self mutilation (lip biting)
  • movement disorders (dystonia)
  • X-linked (boys)

pneumonic is HGPRT . .this is also the enzyme deficiency

  • H (Hyperuricemia)
  • G (Gout)
  • P (pissed off, aggression, self-mutilation)
  • R (Retardation)
  • T (dystonia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the rate limiting enzyme in purine synthesis?

Pyrimidine?

A
  • Glutamine PRPP amidotransferase

- Carbamoul phosphate synthetase 2 (CPS-2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the sources of carbon in the synthesis of purines?

Pyrimidines?

A
  • CO2, Glycine, Tetrahydrofolate

- Aspartate, CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which medication inhibits Ribonucleotide reductase?

A

Hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which medication inhibits Dihydrofolate reductase?

A

Methotrexate and Trimethoprim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which medication inhibits Thymidylate synthase?

A

5-fluorouracil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which medication inhibits Inosine monophosphate dehydrogenase?

Study These Flashcards
A

Mycophenolate and ribavirin

19
Q

Which medication inhibits PRPP amidotransferase?

Study These Flashcards
A

-6-Mercaptopurine (6-MP)

20
Q

what accounts for the positive charge of histone?

what accounts for the negative charge of DNA?

Study These Flashcards
A
  • Lysine and Arginine

- Phosphate groups

21
Q

How many adenine residues are found in a molecule of DNA if one strand contains A=2000, G=500, C=1500, T=1000?

22
Q

A boy with self mutilating behavior, intellectual disability and gout

Study These Flashcards
A

Lesch-Nyhan Syndrome

23
Q

Orotic acid in the urine + elevated serum ammonia?

Study These Flashcards
A

Ornithine transcarbamoylase deficiency

24
Q

Orotic acid in the urine + normal serum ammonia?

Study These Flashcards
A

Orotic aciduria

25
Megaloblastic anemia that does not improve with folate and B12?
Orotic aciduria
26
What are the most common causes of meningitis from birth to 6 months of age
- Group B strep - E. coli - Listeria
27
What is the mechanism of action of dantrolene
-Prevents the release of Ca from sarcoplasmic reticulum of skeletal muscle
28
what substances inhibit the reuptake of norepinephrine
- cocaine | - Tricyclic Antidepressants
29
What enzyme matches amino acids to tRNA?
Aminoacyl tRNA synthetase
30
what antibiotics are inhibitors of prokaryotic protein synthesis at the 30S ribosome?
- Aminoglycosides | - Tetracyclines
31
What antibiotics are inhibitors of prokaryotic protein synthesis at the 50S ribosomal subunit?
- Choramphenicol - Clindamycin - Erythromycin - Lincomycin - Linezolid
32
Which Zoonotic bacterium causes Cat Scratch Fever?
Bartonella
33
Which Zoonotic bacterium causes Lyme disease?
Borrelia Burgdorferi
34
Which Zoonotic bacterium causes Recurrent fever from variable surface antigens?
Borrelia recurrentis
35
Which Zoonotic bacterium causes Bloody diarrhea
-Campylobacter
36
Which Zoonotic bacterium causes Q fever?
Coxiella burnetii
37
Which Zoonotic bacterium causes Tularemia?
Franciella Tularentis
38
Which Zoonotic bacterium causes Leptospirosis
Leptospira
39
Which Zoonotic bacterium causes cellulitis and osteomyelitis from cat or dog bites?
Pasteurella multocida
40
what is the clinical significance of a glycolytic enzyme deficiency
- hemolytic anemia - due to inability to maintain Na/K ATPase --> RBC swelling/ lysis - Pyruvate kinase deficiency is common
41
a muscle biopsy on a pt reveals elevated glycogen levels, elevated fructose 6-phosphate, and decreased pyruvate. What enzyme deficiency do you suspect most?
PFK-1, phosphofructokinase-1
42
what enzyme converts glucose to glucose-6-phosphate?
hexokinase and glucokinase
43
what enzymes are responsible for increasing and decreasing the intracellular levels of fructose-2,6-bisphosphate?
- PFK-2 (fed) . . increases it | - FBPase-2 (fasting) . . decreases it
44
what is the rate limiting enzyme in the glycolytic pathway?
PFK-1

Step 1 (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions