Diuretic

Question 1

Furosemide

1. MOA
2. Uses

Answer 1

Diuretic
1. Bind to Cl part on lumen side of Na/K/2Cl symporter in Ascending Loop of Henle. Increases [Na] in lumen
2. Congestive H.F. - Dogs
Racehorse - b4 race to decrease weight, as well as to help prevent exercise induced pulmonary hemorrhage

Question 2

Hydrochlorothiazide

1. MOA
2. Uses

Answer 2

Thiazide Diuretic

1. Block Na/Cl co-transporter in distal tubule
2. Congestive Heart Failure - not commonly used

Question 3

Chlorothiazide

1. MOA
2. Uses

Answer 3

Thiazide Diuretic

1. Block Na/Cl co-transporter in distal tubule
2. Congestive Heart Failure - not commonly used

Question 4

Spironolactone

1. MOA
2. Uses

Answer 4

Potassium Sparing Diuretic

1. Blocks binding site of aldosterone and prevents formation of Na channels
2. Used with Furosemide to help reduce K loss caused by furosemide

Question 5

Triameterone/Amiloride

1. MOA
2. Uses

Answer 5

Potassium Sparing Diuretic

1. Blocks Na/Cl channels in collecting duct
2. Can be used with furosemide to help prevent hypokalemia