DIURETICS

Question 1

mannitol
Uses:

Contra-Indications:

Answer 1

Uses:
• Acute Congestive Glaucoma
• Cerebral edema
Contra-Indications:
• Cerebral hemorrhage
• Pulmonary edema

Question 2

CARBONIC ANHYDRASE INHIBITORS
→ Acts on Proximal tubule
→ Include:

Indications:

Answer 2

→ Include:
Acetazolamide – Given orally or IV
Brinzolamide
Dorzolamide
Indications:
Glaucoma (Angle closure glaucoma)
Mountain Sickness [DOC]

Question 3

LOOP DIURETICS
→ Act on thick ascending limb of loop of Henle
→ Inhibit Na+
K+
2Cl–
symporter
→ Include

Answer 3

Furosemide
Torsemide
Bumetanide
→ High ceiling diuretics [High efficacy Diuretics]Q
→ Effectve in renal failure

Question 4

THIAZIDES
→ Act on early distal tubule
→ Inhibit Na+ – Cl–
symporter
Included
Uses
•

Answer 4

Include
Thiazides
Thiazide-like diuretics
Chlorothiazide
Methiazide
Polythiazide
Indapamide
Metolazone
Uses
• Hypertension (DOC)
– Metolazone is effective in renal failure unlike
other thiazides
• Recurrent renal calcium stones
• Diabetes insipidus
• Osteoporosis
• Recurrent renal calcium stones

Question 5

Epithelial Na+ channel Blockers
– Triamterene
– Amiloride

Answer 5

DOC for Conn’s Syndrome
- DOC for Edema in Cirrhosis
- DOC for Resistant hypertension