Flashcards in Diuretics Deck (24):
Name 6 common nephrotoxic drugs
Aminglycosides (gentamycin etc)
What 4 drugs are indicated for heart failure?
A- ACE inhibitor (eg Lisinopril)
B- B blocker
D- loop & thiazide diuretic, Spironolactone (for its anti-aldosterone effects)
Why is Spironolactone indicated in heart failure?
not for its diuretic effects but for its anti-aldosterone effects
What 5 drugs are indicated in hypertension?
What two drugs are indicated in decompensated liver disease (with regards to oedema)?
What is the mechanism of Loop Diuretics?
Block NKCC2 in the thick ascending limb of loop of henle
Name two loop diuretics
Name a side effect of Furosemide
Name a side effect of Bumetanide
Name 4 indications for Loop Diuretics
Acute pulmonary oedema
What is the mechanism of action of Thiazide diuretics?
Blocks NaCl transporter (NCCT)
Name 2 positives of thiazide diuretics
better in osteoporosis
Name 3 side effects of thiazide diuretics
Why are thiazide diuretics better in osteoporosis?
As there is less reuptake of Na, there is less Na in the cell. Therefore leads to more movement of Na into the cell, in place of Ca (therefore more uptake of Ca)
Name 2 ENaC blockers
What is the mechanism of action of Amiloride?
block epithelial Na channel
Usually used alongside K losing diuretics
Name 2 potassium sparing diuretics
Spironolactone (aldosterone antagonist)
Amiloride (ENaC blocker)
Name two side effects of Spironolactone
What is the best diuretic for primary hyperaldosteronism, ascites, oedema? Or when other drugs havent worked for HTN?
Name 2 carbonic anhydrase inhibitors
Name 4 indications for Carbonic Anhydrase inhibitors
Name 4 indications for Mannitol
Kidney failure with low urine output
To increase elimination toxins
Name 2 side effects of Carbonic Anhydrase inhibitors
Metabolic acidosis (due to increased HC03- loss)
Risk of renal stones due to increased HCO3- in the urine