DJD of Extra-spinal and Spinal Origin Flashcards
(39 cards)
T/F: Primary OA is age-related and generalized.
TRUE [some refer to hand OA only, some refer to knee, spine, and hip]
T/F: Secondary OA is post-traumatic or a result of other joint afflictions
TRUE
What does EOA stand for?
Erosive osteoarthritis
What is the most common articular disorder and can be thought of as a gradual biochemical breakdown of articular (hyaline) cartilage?
OA
OA is currently believed to involve the entire joint complex, what three things does it include?
- Cartilage
- Spongy bone
- Synovium
- Subchondral bone
Cartilage, synovium, subchondral bone
Are these joints listed below, typical or atypical?
- Knees, hips, Cervical Lumbosacral spine, DIP, 1st CMC [thumb, and trapezium-scaphoid-trapezoid complex], 1st TMT [hallux]
Typical [can also be thought of as ‘weight-bearing’ bones]
Are these joints listed below, typical, atypical or 2ndary?
- Wrist, elbow, shoulder, ankle, MCP
Atypical or 2ndary
T/F: The etiology of OA is poorly understood, and daily stresses contribute to chondrocyte disruption and decreased catabolic processes. Subtle or unrecognized congenital or acquired joint alterations may accelerate breakdown of articular cartilage.
FALSE: Daily stresses contribute to chondrocyte disruption and INCREASED catabolic processes. Subtle or unrecognized congenital or acquired joint alterations may accelerate breakdown of articular cartilage.
Age, Obesity, Trauma, significant family history, muscle weakness (instability), osteochondral and meniscal injury and nutritional deficiency are all considered what?
Risk factors
A process known as _____ followed by subchondral cysts (microcysts) formation and abnormal proliferation of marginal bone known as osteophytes
Eburnation
In the pathophysiology of OA, initial damage to chondrocytes leads to reactive increase in _____ with thickening and softening of _____ cartilage followed by subsequent microscopic flaking, fibrillation (vertical clefts) and breakdown, thinning and denudation of the underlying bone.
- Proteoglycan
- Hyaline
T/F: In dealing with pathophysiology, abnormal hypovascularity of the subchondral bone leads to osseous thickening and hypodensity.
FALSE: In dealing with pathophysiology, abnormal HYPERvascularity of the subchondral bone leads to osseous thickening and HYPERdensity
What are the general radiologic features of OA, the acronym of L.O.S.S. is used, what does it stand for?
L - loss of joint space
O - osteophytes
S - subchondral sclerosis
S - subchondral cysts
What is the most common site of extra-spinal OA? And why is it common?
- Knee OA
- It is common due to its 3-compartment articulation
What are the 3-compartments of the knee?
- Medial femorotibial compartments
- lateral femorotibial compartments
- patellofemoral compartment
Which compartment of the knee is most commonly affected by OA?
- Medial femorotibial compartment
Is genu varum or genu valgum deformity more common in the knee?
Genu varum
[Note: knee deformities can contribute to unicompartmental OA]
Joint stiffness in the morning lasting less than 30 minutes can be confidently classified as what?
DJD
At rest, there is something called a ‘gelling phenomenon’
Joint stiffness in the AM lasting longer than 30 minutes can be confidently classified as what?
Inflammatory Arthritis [ex. rheumatoid arthritis]
Crepitus and some swelling is known as…
bland synovitis
What are the demographics of Knee OA?
- > 50% of adults over 65 y/o
- Women > Men (7:1), due to sex hormone decline at 55 y/o
- Obese patients may develop OA earlier
Is there systemic involvement with knee OA?
NO!
T/F: Positive blood tests for CRP, ESR, RF, ANA, and an elevated WBC in Knee OA
FALSE: Negative blood tests for CRP, EAR, RF, ANA, and no elevation of WBC
What type of imaging is used to look at OA, and what type is used to grade the severity of OA
X-ray, and X-ray
