DNA viruses

Question 1

Adenoviridae was 1st isolated in?

Answer 1

adenoid tissue

Question 2

True or False:

Adenoviridae is an enveloped, icosahedral, dsDNA

Answer 2

(FALSE)

Naked

Question 3

Size of adenoviridae

Answer 3

70-90nm

Question 4

Common serotypes of adenoviridae

Answer 4

1, 8, 11, 21, 35, 37, 40

Question 5

Serotype of adenoviridae that is commonly associated with Gastroenteritis

Answer 5

40, 41

Question 6

True or False:

Serotype 4 of adenoviridae causes ARD

Answer 6

(FALSE)

Serotype 14

Question 7

Serotypes 40 and 41 of adenoviridae are also known as

Answer 7

Enteric adenoviruses

Question 8

This is a prominent feature of enteric adenoviruses

Answer 8

Diarrhea

Question 9

This virus is identified but not serotyped by EIA

Answer 9

Adenoviridae serotype 40 & 41

Question 10

True or False:

Adenoviruses are stable

Answer 10

True

Question 11

This virus produces a grapelike cluster cytopathic effect

Answer 11

Adenoviridae

Question 12

HHV-3 is also known as

Answer 12

Varicella-Zoster virus

Question 13

HHV-4 is also known as

Answer 13

Epstein-Barr virus

Question 14

HHV-5 is also known as

Answer 14

Cytomegalovirus

Question 15

HSV-1 & 2 belong to what genus?

Answer 15

Simplexvirus

Question 16

2 categories of herpes simplex virus

Answer 16

Primary

Recurrent

Question 17

5 types of herpes infections

Answer 17

Oral herpes
Genital herpes
Neonatal herpes
HSV-Encephalitis
Ocular herpes

Question 18

True or False:

Neonatal herpes is more severe when HSV-1 is involved

Answer 18

(FALSE)

HSV-2

Question 19

It is the leading cause of fatal sporadic encephalitis in United States

Answer 19

HSV

Question 20

What treatment is used for HSV-Encephalitis

Answer 20

IV antiviral treatment

Question 21

It is also known as the HSV of the conjunctiva

Answer 21

Ocular herpes

Question 22

What is required for a culture-confirmed diagnosis of Encephalitis

Answer 22

Brain biopsy material

Question 23

It replicates rapidly and cytopathic effect can be seen within 24 hours

Answer 23

HSV

Question 24

What is the antibody used to type HSV

Answer 24

Monoclonal antibodies

Question 25

Old tests for HSV uses _______ preparations from lysed cell culture of the virus

Answer 25

Crude antigen

Question 26

New tests for HSV uses recombinant or affinity purified __________ glycoprotein

Answer 26

type-specific

Question 27

ELVIS test is known as

Answer 27

Enzyme-linked, virus-inducible system

Question 28

Baby hamster kidney cells are used for this test

Answer 28

ELVIS test

Question 29

What color is formed in ELVIS test

Answer 29

Blue

Question 30

Most common congenital infection in United States

Answer 30

Cytomegalovirus

Question 31

Virus that spreads easily in crowded populations

Answer 31

CMV

Question 32

True or False: | In a symptomatic CMV patient, there is an infectious mononucleosis-like illness

Answer 32

(FALSE) | Asymptomatic

Question 33

When is CMV best confirmed in infants?

Answer 33

first 2 weeks of life

Question 34

In CMV, after how many weeks does CPE appear?

Answer 34

3 weeks

Question 35

This test is based on the detection of 65-kDa and Lower-matrix phosphoprotein

Answer 35

Viral antigenemia test

Question 36

This virus belongs to the genus Lymphocryptovirus

Answer 36

Epstein-Barr virus

Question 37

Cancers associated with EBV

Answer 37

Burkitt lymphoma Hodgkin disease Nasopharyngeal carcinoma

Question 38

Where can EBV be recovered?

Answer 38

Oropharynx

Question 39

This virus can be transmitted via infected saliva

Answer 39

EBV

Question 40

True or False: | In EBV, young children are always symptomatic

Answer 40

(FALSE) | Asymptomatic

Question 41

the cell targeted by EBV

Answer 41

B lymphocytes

Question 42

Antibodies produced due to EBV

Answer 42

Heterophile antibodies

Question 43

This is an excellent rapid screening test for heterophile antibodies

Answer 43

Paul-Bunnel heterophile antibody test

Question 44

It is also known as the reactivation of VZV

Answer 44

Shingles

Question 45

Cytopathic changes in VZV is evident for how many days

Answer 45

3-7 days

Question 46

The standard test for diagnosis of VZV

Answer 46

PCR

Question 47

Which variant is common cause of HHV-6

Answer 47

Variant B

Question 48

The most likely route of transmission of HHV-6

Answer 48

Saliva

Question 49

Serology is not helpful in the diagnosis of HHV-6 unless _________ are available

Answer 49

Paired sera

Question 50

When can IgM be detected in HHV-6?

Answer 50

5 days after incubation

Question 51

2 tests that is most sensitive and specific for diagnosing primary HHV-6

Answer 51

PCR | Viral load testing

Question 52

The receptor for HHV-7

Answer 52

CD4

Question 53

True or False: | HHV-7 occurs later in life than HHV-6

Answer 53

TRUE

Question 54

This virus belongs to the genus Rhadinovirus

Answer 54

HHV-8

Question 55

HHV-8 is also known as

Answer 55

Kaposi sarcoma-associated herpesvirus

Question 56

HHV-8 is usually transmitted by ________ contact in North America and Europe

Answer 56

Sexual contact

Question 57

The pattern of infection of HHV-8 is similar to what virus

Answer 57

HSV-2

Question 58

This virus is associated with common warts and cervical cancer

Answer 58

Papillomaviridae

Question 59

What do you use for rinsing Cervical HPV lesions?

Answer 59

5% acetic acid

Question 60

Cells that are indicative of HPV infection

Answer 60

Koilocytes

Question 61

Condylomata acuminata is also known as

Answer 61

Genital warts

Question 62

2 types of HPV that causes majority of cervical cancers

Answer 62

Type 16 & 18

Question 63

Used for the detection of HPV DNA

Answer 63

Nucleic acid probes

Question 64

Largest DNA virus

Answer 64

Poxviridae

Question 65

Brick-shaped virus

Answer 65

Poxviridae

Question 66

Variola virus belongs to what genus

Answer 66

Orthopoxvirus

Question 67

Variola virus causes what disease?

Answer 67

Smallpox

Question 68

Virus that has synchronous progressive rash w/ fever

Answer 68

Variola virus

Question 69

Macular rash progress into _______

Answer 69

Pustules

Question 70

He demonstrated the efficacy of vaccination against smallpox

Answer 70

Edward Jenner

Question 71

This virus was introduced by rodents imported from Africa

Answer 71

Monkeypox virus

Question 72

Smallest DNA virus

Answer 72

Parvoviridae

Question 73

Principal pathogen in Parvoviridae

Answer 73

Parvovirus B19

Question 74

The initial viral isolate of parvovirus B19 was observed using?

Answer 74

Electron microscope

Question 75

Also known as fifth disease

Answer 75

Erthema infectiosum

Question 76

Virus that gives a slapped cheek appearance

Answer 76

Parvovirus B19

Question 77

This virus is characterized by a decrease in RBC production in the Bone marrow

Answer 77

Parvovirus B19 Viremia

Question 78

This occurs within 1 week of patients with Parvovirus B19 Viremia

Answer 78

Reticulocytosis

Question 79

Novel parvovirus

Answer 79

Human Bocavirus

Question 80

Human Bocavirus occurs as a co-infection with ____ & ____

Answer 80

RSV (Respiratory scytial virus) | Human metapneumovirus