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Sketchy Micro > DNA Viruses > Flashcards

DNA Viruses Flashcards

1
Q

Parvovirus is

A

Naked single stranded DNA virus

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2
Q

The smallest DNA virus is

A

Parvovirus

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3
Q

Parvovirus transmission through

A

Respiratory droplets

Vertical transmission

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4
Q

Parvovirus B19 cause in children

A

Slapped cheek fever aka fifth disease

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5
Q

Parvovirus rash , erythema infectiosum

A

raised, indurated rash Start on the face and move downward

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6
Q

Parvovirus B19 cause in adults

A
  1. Joint pain , arthritis and edema

2. Aplastic anemia

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7
Q

Parvovirus B 19 in fetus cause

A

severe anemia, CHF, hydrops fetalis; spontaneous abortions

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8
Q

Polyomavirus is

A

Naked Circular double stranded DNA virus

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9
Q

Polyomavirus JC causes

A

PML Progressive multifocal leukoencephalopathy

Occur mainly in AIDS or immunocompromised patients with CD4 count <200.

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10
Q

Progressive multifocal leukoencephalopathy cause demyelination leads to

A

non-enhancing multifocal brain lesions in white matter

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11
Q

POLYOMAVIRUS BK causes

A

Nephropathy particularly in transplant patients, hemorrhagic cystitis

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12
Q

Parvovirus is

A

Naked single stranded DNA virus

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13
Q

The smallest DNA virus is

A

Parvovirus

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14
Q

Parvovirus transmission through

A

Respiratory droplets

Vertical transmission

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15
Q

Parvovirus B19 cause in children

A

Slapped cheek fever aka fifth disease

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16
Q

POLYOMAVIRUS BK causes

A

Nephropathy particularly in transplant patients, hemorrhagic cystitis

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17
Q

Progressive multifocal leukoencephalopathy cause demyelination leads to

A

non-enhancing multifocal brain lesions in white matter

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18
Q

Polyomavirus JC causes

A

PML Progressive multifocal leukoencephalopathy

Occur mainly in AIDS or immunocompromised patients with CD4 count <200.

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19
Q

Polyomavirus is

A

Naked Circular double stranded DNA virus

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20
Q

Parvovirus B 19 in fetus cause

A

severe anemia, CHF, hydrops fetalis; spontaneous abortions

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21
Q

Parvovirus B19 cause in adults

A
  1. Joint pain , arthritis and edema

2. Aplastic anemia

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22
Q

Parvovirus rash , erythema infectiosum

A

raised, indurated rash Start on the face and move downward

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23
Q

HPV is

A

Naked DNA virus

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24
Q

HPV 1-4 associated with

A

Verruca vulgaris = cutaneous common wart

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25
Q

HPV 6 and 11 associated with

A
  1. Laryngeal papillomas aka recurrent respiratory papillomatosis
  2. anogenital warts aka Condylomata acuminate
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26
Q

HPV 16 ,18, 31 , 33 associated with

A

Anogenital cancers

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27
Q

Guardasil vaccine

A

inactivated subunit vaccine covers serotypes 6, 11, 16, and 18

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28
Q

HPV malignancy pathogenesis

A
  • E6 inhibits tumor-suppressor gene p53

- E7 inhibits tumor-suppressor gene Rb

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29
Q

Pap smear

A

screening of cervical cancer (finding of koilocytic cells)

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30
Q

• Is an AIDS-defining illness; ………………….. increases the risk of HPV-related cancers

A

immunosuppression

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31
Q

HSV is

A

Enveloped dsDNA and linear virus

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32
Q 
Cowdry bodies (intranuclear inclusion bodies)
Associated with
A

HSV

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33
Q

HSV transmission

A

Sexual , vertical

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34
Q

HSV1 cause

A

Gingiovostomatitis
Cold sore (Herpes labialis)
Keratoconjunctivitis(serpiginous corneal ulcers on fluorescein slit lamp exam seen)
Erythema Multiform may appear 1-2 weeks after infection

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35
Q

HSV1 latent in

A

Trigeminal ganglia

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36
Q

Herpes rash has

A

“dew on rose petals” appearance

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37
Q

Herpetic Whitlow

A

Herpes rash on the fingers, more common in dentists

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38
Q

HSV2 infection cause

A

Painful inguinal lymphadenopathy

Aseptic meningitis in adolescents & adults

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39
Q

HSV2 lies dormant in

A

Sacral ganglia

40
Q

Tzanck test

A

a smear of an opened skin vesicle to detect multinucleated

giant cells commonly seen in HSV-1, HSV-2, and VZV infection

41
Q

Herpes treatment

A

Acyclovir

42
Q

Varicella zoster virus is

A

Enveloped dsDNA (a member of Herpes family)

43
Q

1ry infection of VZV

A

Chicken pox

44
Q

VZV transmission

A

Respiratory droplets , vertical (TORCH)

45
Q

Adult presentation of chickenpox is with

A

pneumonia and encephalitis; occurs especially in immunocompromised patients

46
Q

Vaccine of varicella zoster is

A

Live attenuated vaccine for children

47
Q

VZV treatment

A

Acyclovir , Famcyclovir and Valacyclovir

48
Q

VZV remains latent in

A

Dorsal root ganglia

49
Q

Reactivation of VZV occur with

A

Stress , aging and immune compromised state

50
Q

Reactivated form of VZV infection is called

A

Shingles aka Herpes Zoster

51
Q

Herpes zoster or Shingles present with

A

painful vesicles that have “dew drops of rose petals”

appearance to one dermatome

52
Q

Post-Herpatic Neuralgia

A

the pain that results after the rash subsides and persists for months.

53
Q

Herpes Zoster Opthalmicus

A

vision loss is possible when CN V1 is affected

54
Q

Congenital Varicella Syndrome; presents with

A

limb hypoplasia, cutaneous dermatomal scarring, and

blindness

55
Q

CMV is a member of ……………. family

A

Herpes

56
Q

CMV remains latent in

A

mononuclear leukocytes like B and T cells and macrophages

57
Q

CMV transmission

A

Congenital transfusion(TORCHES), sexual contact

58
Q

Congenital CMV characterized by

A 
Blueberry muffin rash
Jaundice and hepatosplenomegaly 
Sensorineural deafness 
Periventricular calcifications
Seizures 
Hydrops fetalis
59
Q

………. is #1 cause of sensorineural hearing loss in children AND congenital viral infection

A

CMV

60
Q

CMV In a transplanted organ patient or in an AIDS patients it causes

A

Interstitial pneumonitis

61
Q

In AIDS patients , CMV causes

A

retinitis
Esophagitis with linear ulcerations
CMV colitis with ulcerated walls

62
Q

Owl-eye inclusion (enlarged cells with basophilic intranuclear and
intracytoplasmic inclusions ) seen with

A

CMV infection

63
Q

CMV treatment

A

ganciclovir or foscarnet with human immunoglobulin In patients who are Resistance to
ganciclovir is through UL97 gene

64
Q

CMV in Children and Adults causes

A

Mononucleosis (fever, fatigue, splenomegally and atypical lymphocytosis)

65
Q

EBV primarily transmitted through

A

Saliva aka ‘‘kissing disease”

66
Q

EBV causes kissing disease that presents with

A

Fever
pharyngitis and tonsillar exudates
Tender lymphadenopathy
hepatosplenomegaly

67
Q

atypical reactive CD8+ cytotoxic T cells, aka Downey Cells; seen on blood smear is seen with

A

EBV infection

68
Q

EBV remains latent in

A

B cells

69
Q

EBV envelope glycoprotein bind …………….. to infect B cells

A

CD21

70
Q

If mistakenly given amoxicillin or ampicillin for EBV treatment , can develop characteristic

A

Maculopapular rash

71
Q

Associated malignancies with EBV

A

Burkitt Lymphoma
Nasopharyngeal carcinoma
Hodgkin B Cell Lymphoma of Mixed Cellularity

72
Q

Hodgkin B Cell Lymphoma of Mixed Cellularity diagnosed with

A

Reed-Sternberg cells that look like

owl eyes

73
Q

African or Endemic form of Burkitt Lymphoma involve

A

The maxilla or mandible

74
Q

Nasopharyngeal carcinoma: predominately found in

A

Asian adults

75
Q

Hairy Oral Leukoplakia in AIDS patients

A

A non cancerous lesion that occur with EBV infection

76
Q

Diagnosis for EBV infection

A

Monospot test

77
Q

Patient with mononucleosis should Avoid contact sports until resolution due to

A

Risk of splenic rapture

78
Q

HHV-6 infects

A

CD4 T cells

79
Q

Roseola or exanthema subitum is characterized by

A

Fever generally lasts 4 days

once fever subsides, a lacy(شريطي) diffuse blanching macular body rash appears that spares the face

80
Q

Children with roseola can develop

A

Febrile seizures

81
Q

HHV-8 causes

A

Kaposi sarcoma

82
Q

AIDS and immunosuppression associated with

A

Kaposi sarcoma

83
Q

Kaposi sarcoma causes

A
  1. dark violaceous( بنفسجي اللون) plaques or nodules on the nose, extremities, and mucous membranes
  2. proliferation of vasculture (desregulation of VEG-F)
84
Q

Kaposi sarcoma lesions can be found in

A

GIT but more commonly on hard palate

85
Q

HHV-8 can also infect B cells and cause

A

B cell lymphoma (primary effusion lymphoma)

86
Q

Kaposi sarcoma have Higher incidence in

A

Russian men and African populations

87
Q

Kaposi sarcoma can be confused with

A

bacillary angiomatosis from B. henselae

88
Q

Poxviruses make their own

A

Envelope

89
Q

The only DNA virus that replicates in the cytoplasm and has own RNA polymerase is

A

Pox virus

90
Q

Pox virus diagnosis

A 
Guarnieri bodies(inclusion bodies) found in infected cells
(intracytoplasmic)
91
Q

The largest known DNA virus is

A

Pox virus

92
Q

Small pox virus lesions

A

all vesicles are in the **same stage of development –

synchronous rash – as opposed to the nonsynchronous Varciella chickenpox rash

93
Q

Molluscum contagiosum virus(a member of pox family) causes

A

flesh colored papule, dome shaped, with central umbilication on the skin

94
Q

Molluscum contagiosum affects

A

the trunk region in children

95
Q

diffuse Molluscum contagiosum in adults suggest

A

Suggest HIV infection

Sketchy Micro (3 decks)

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