Donepezil Hydrochloride

Question 1

Trade name

Answer 1

Aricept

Question 2

Generic name

Answer 2

Donepezil Hydrochloride

Question 3

Class of drug

Answer 3

Acetylcholinesterase inhibitor

Question 4

Usual dosage

Answer 4

Adults: Initially, 5 mg P.O. daily. After
4 to 6 weeks, may increase dosage to 10mg at bed time.

Question 5

Administration

Answer 5

● Give with or without food.
● For best response, give at bedtime.
Route P.O.

Question 6

What it is used for? Action

Answer 6

Anti-Alzheimer’s agent. Reversibly inhibits acetylcholinesterase
hydrolysis in CNS, leading to increased
acetylcholine level and temporary cog-
nitive improvement in patients with
Alzheimer’s disease.

Question 7

Complications/precautions

Answer 7

Use cautiously in:
• cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma, or sick sinus syndrome
• patients at risk for developing ulcers, such as those with history of ulcer disease or those concurrently receiving
NSAIDs
• pregnant or breastfeeding patients
• children (safety and efficacy not established).

Question 8

Nursing Considerations:

Answer 8

Monitor for GI bleeding, monitor cognitive function, educate on adherence. Schedule to be taken at night because can cause bradycardia, pt may faint. (Ослабеть)

Question 9

Adverse effects

Answer 9

Bradycardia, hypotension, difficulty with urination ,
bronchoconstriction, GI tract hyper motility, nausea, diarrhea, insomnia, muscle cramps, fatigue

Question 10

Interaction

Answer 10

May interact with NSAIDs, increasing risk of GI bleeding.