Dopamine

Question 1

Brand name of Dopamine Hydrochloride

Answer 1

Inotropin

Question 2

Drug class of Dopamine

Answer 2

Sympathomimetic, vasopressor, inotropic agent

Question 3

Dopamine’s mechanism of action

Answer 3

Immediate metabolic precursor to nor-epinephrine. Produces positive inotropic, and chronotropic effects. Dilates renal and splanchnic vasculature. Constricts systemic vasculature, increasing blood pressure and preload. Increases myocardial contractility and stroke volume.

Question 4

Indications of Dopamine

Answer 4

Cardiogenic and septic shock, hypotension with low cardiac output states, distributive shock, symptomatic bradycardia

Question 5

Contraindication of Dopamine

Answer 5

Hypovolemic shock, pheochromocytoma (adrenal tumor that causes persistent or episodic high blood pressure), tachydyrhythmias, ventricular fibrillation.

Question 6

Adverse effects of Dopamine

Answer 6

Extravasation may cause tissue necrosis. Headache, anxiety, dyspnea, dysrthythmias, hypotension, hypertension, palpitations, chest pain, increased myocardial oxygen demand, PVCs, nausea, and vomiting.

Question 7

Precautions of Dopamine

Answer 7

Incompatible with alkaline solutions, MAOI’s &
Bretylium will enhance effects, beta blockers
Will antagonize effects. Do not give with
Phenytoin (hypotension, bradycardia, seizures)

Question 8

Adult dose and admin of Dopamine

Answer 8

2 to 20 mcg/kg/min titrate to effect
2 to 5 mcg/kg/min (low dose)
5 to 15 mcg/kg/min (mid dose)
15 to 20 mcg/kg/min (high dose)

Question 9

Pedi dose of Dopamine

Answer 9

2-20 mcg/kg/min IV/IO slowly titrated to effect