DOTD pt2

Question 1

Drug Class: Verapamil

Answer 1

Class IV antiarrythmic

Question 2

Drug Class: Amiodarone

Answer 2

Class III antiarrythmic

Question 3

Drug Class: Ezetimibe

Answer 3

Cholesterol absorption inhibitor

Question 4

Drug Class: Dapagliflozin

Answer 4

SGLT-2 inhibitor
Na-Glucose co-transporter

Question 5

Drug Class: Clopidogrel

Answer 5

ADP receptor antagonists

Question 6

Indications: Verapamil

Answer 6

SVT

Question 7

Indications: Amiodarone

Answer 7

Broad antiarrhythmic use

Question 8

Indications: Ezetimibe

Answer 8

Hyperlipidaemia

Question 9

Indications: Dapagliflozin

Answer 9

T2DM, HF with reduced ejection fraction

Question 10

Indications: Clopidogrel

Answer 10

Stroke, 2nd DAPT agent

Question 11

Mechanism of action: Verapamil

Answer 11

Ca channel blocker -> increases delay at AVN

Question 12

Mechanism of action: Amiodarone

Answer 12

Inhibits cardiac delayed rectifier potassium channel activity

BUT ALSO…
Na channels (class I)
Beta adrenergic receptors (class II)
L-type Ca channels (class IV)

Question 13

Mechanism of action: Ezetimibe

Answer 13

Inhibits NPC1L1 transporter at brush border in small intestines

Question 14

Mechanism of action: Dapagliflozin

Answer 14

Competitive reversible inhibition of SGLT-2 in PCT

Question 15

Mechanism of action: Clopidogrel

Answer 15

Inhibit binding of ADP to P2Y12 receptor -> inhibit activation of GPIIb/IIIa receptors

Question 16

Adverse drug reactions: Verapamil

Answer 16

Constipation, bradycardia, heart block

Question 17

Adverse drug reactions: Amiodarone

Answer 17

Pulmonary fibrosis, hypo/hyperthyroidism, photosensitivity, hepatitis

Question 18

Adverse drug reactions: Ezetimibe

Answer 18

Abdo pain, GI upset, angioedema

Question 19

Adverse drug reactions: Dapagliflozin

Answer 19

UTI, polyuria, ?pancreatitis

Question 20

Adverse drug reactions: Clopidogrel

Answer 20

Bleeding, GI upset, rarely thrombocytopenia

Question 21

Contraindications, Warnings, DDIs: Verapamil

Answer 21

Beta blockers (also suppress AVN conduction velocity thus risk of heart block)

Question 22

Contraindications, Warnings, DDIs: Amiodarone

Answer 22

Increases plasma [digoxin, warfarin, verapamil]

Question 23

Contraindications, Warnings, DDIs: Ezetimibe

Answer 23

Mindful if prescribed with statins - theoretical increased risk of rhabdo

Question 24

Contraindications, Warnings, DDIs: Dapagliflozin

Answer 24

Antihypertensives, other hypoglycaemic agents

Question 25

Contraindications, Warnings, DDIs: Clopidogrel

Answer 25

Requires cytochrome Ps for activation so CYP inhibitors (omeprazole, ciprofloxin, erthromycin)