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Flashcards in Down's Syndrome Deck (3)
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1
Q

What causes Down’s syndrome

A

Trisomy of Chromosome 21 due to nondisjunction of chromosome 21 during anaphase I,II
Robertsonian translocation: translocation of the long arm of chromsome 21 to another chromosome, often 14

2
Q

What are some of the symptoms of the disorder

A

Mental impairment, stunted growh, umbilical hernia, flat head, flattened nose and more

3
Q

What is the relationship between maternal age and the disease

A

Risk increases with the age of the mother.

95% of cases are to due to nondisjunction in ovum