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LMBR KA2 Knowler NEJM 2002 > DPP > Flashcards

Flashcards in DPP Deck (3)
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1

In Knowler's DPP

1) What was the control diet ?

2) What was the Rx diet ?  Did it change ?

 

Control: Plc (NCEP step 1 diet)

 LS: >= 7% weight loss + >= 150 min phys active/wk

- dietary fat < 25%. If no wt loss add calorie goal.

 

 

2

In Knowler's DPP

Population:

Intervention:

Control:

Outcomes

Pop:

- 3234 persons w IGT (inc fasting [glu] & post load [glu]

- x age 51, BMI 34, 68% female, 45% minorities in USA

Int: (3)

a) MF 850 mg BID

b) LS: >= 7% weight loss + >= 150 min phys active/wk

- dietary fat < 25%. If no wt loss add calorie goal.

Control: Plc (NCEP step 1 diet)

Outcomes

1'- Incidence of NIDDM (ie progression of IGT)

2'

3

Results:

1) How long was study

2) Incidence of DM /100 person-yrs

3) Relative reduction of DM in LS vs Plc

4) Relative Rate of dec DM w MF

5) NNT to prevent one case of DM

6) How effective at prev DM was LS vs MF ?

 

BR 333-4

1) Ended early at 2.8 yrs average due to (+) results

2) Incidence/100 pers-yrs

Plc: 11.0  MF: 7.8  LS: 4.8  (ie 11-8-5)

3) Rate of DM in LS vs Plc dec by 58% 

4) MF dec DM by 31%

5) NNT prevent: MF=14, LS = 7

6) LS ws almost twice as effective as MF