DPP

Question 1

In Knowler’s DPP

1) What was the control diet ?
2) What was the Rx diet ? Did it change ?

Answer 1

Control: Plc (NCEP step 1 diet)

LS: >= 7% weight loss + >= 150 min phys active/wk

• dietary fat < 25%. If no wt loss add calorie goal.

Question 2

In Knowler’s DPP

Population:

Intervention:

Control:

Outcomes

Answer 2

Pop:

• 3234 persons w IGT (inc fasting [glu] & post load [glu]
• x age 51, BMI 34, 68% female, 45% minorities in USA

Int: (3)

a) MF 850 mg BID
b) LS: >= 7% weight loss + >= 150 min phys active/wk
- dietary fat < 25%. If no wt loss add calorie goal.

Control: Plc (NCEP step 1 diet)

Outcomes

1’- Incidence of NIDDM (ie progression of IGT)

2’

Question 3

Results:

1) How long was study
2) Incidence of DM /100 person-yrs
3) Relative reduction of DM in LS vs Plc
4) Relative Rate of dec DM w MF
5) NNT to prevent one case of DM
6) How effective at prev DM was LS vs MF ?

BR 333-4

Answer 3

1) Ended early at 2.8 yrs average due to (+) results
2) Incidence/100 pers-yrs

Plc: 11.0 MF: 7.8 LS: 4.8 (ie 11-8-5)

3) Rate of DM in LS vs Plc dec by 58%
4) MF dec DM by 31%
5) NNT prevent: MF=14, LS = 7
6) LS ws almost twice as effective as MF