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Flashcards in Drug deck Deck (59):
1

What receptors do classical antipsychotics act on?

D2, M1, H1, α1

2

Give 2 examples of a classical antipsychotic

Haloperidol
Chlorpromazine

3

Where do atypical antipsychotics act?

5HT2, D2 has some H1, M1 and α1 effects too

4

Why use atypical antipsychotics?

Better at dealing with negatve symptoms of SCZ also less extrapyrimdal side effects

5

What is the gold standard antipsychotic?

Clozapine

6

What condition are patients at risk of with long term classical antipsychotic use?

Tardive dyskinesia

7

MOA of statins

Inhibition of HMG-CoA reductase resulting in less LDL and a mild increase in HDL

8

SE of statins

Myopathy
Rhabdomyolysis

9

MOA of NSAIDs

COX inhibitors leading to reduction in production of prostagladins and thromboxane A2

10

SE of NSAIDs

Hyperkalaemia
Bronchospam
Peptic ulcer
Hepatotoxic
Ototoxicity
Reduced GFR

11

SE of morphine

Respiratory depression
Urinary retention
Constipation
N+V

12

MOA of COCP

Inhibits ovulation via inhibition of HPG axis via release of oestrogen + progestogen

13

3 Adv of COCP

Reliable
Reversible
Cycle control

14

Absoulte CI for COCP (3 of many)

Breastfeeding up to 6 weeks post partum
Up to 3 weeks post-partum with other risk factors for VTE
Age >35 and smoker >15 cigarettes a day
Blood pressure >160/100
Ischaemic heart disease or stroke or vascular disease (ever)
Personal history of DVT (ever)
Thrombogenic mutation (e.g. factor V leiden)
Major surgery with immobilisation
Atrial fibrillation
Migraine with aura within the last 5 years
Breast cancer

15

MOA of Progesterone contraception

May inhibit ovulation
Thickened and viscid cervical mucus
Endometrium unstable for implantation

16

Cons of progesterone contraception

Amenorrhoea/ irregular bleeding
Taken at same time each day (cerazette 12 hours)
Increased risk functional ovarian cysts
If did get pregnant increased risk ectopic

17

What class of antibiotics target the bacterial cell wall?

Beta-lactams - Penicillins, cephalosporins, carbapenems, glycopeptides

18

What class of antibiotic targets RNA and protein synthesis

Macrolides
Lincosamides
Tetracyclines
Aminoglycosides

19

What class of antibiotic targets DNA structure and function?

Quinolones
Nitroimidazoles
Nitrofurantoin

20

What class of antibiotic targets Folic acid synthesis?

Antifolates

21

Give 4 examples of penicllins

Penicillin
Amoxicillin (enhanced uptake)
Flucloxacillin (penicillinase - resistant
Co-amoxiclav (beta-lactamase inhibitor)
Piperacilin-tazobactam (anti-pseudomonal)

22

Give 4 examples of cephalosporins

Cephalexin (1st gen)
Cefuroxime (2nd gen)
Cefotaxime (3rd gen)
Ceftriaxone (4th gen)

23

Give 2 examples of carbapenems

Meropenem
Ertapenem

24

Give 2 examples of glycopeptides

Vancomycin
Teicoplanin

25

Give 2 examples of macrolides

Erythromycin
Clarithromycin

26

Give an example of a lincosamide

Clindamycin

27

Give an example of an aminoglycoside

Gentomycin

28

Give 2 quinolones

Ciprofloxacin
Levofloxacin

29

Give an exmaple of a nitroimidazole

Metronidazole

30

MOA and use of nitrofurantoin

Targets bacterial DNA synthesis
Used in uncomplicated UTIs

31

2 examples of anti-folates

Trimethoprim, sulphoamides

32

1st line antibiotic for CAP

Amoxicillin

33

1st line antibiotic for soft tissue infection

Flucloxacillin

34

Best antibiotic for an anaerobic infection e.g. abscess?

Metronidazole (Nitroimidazole) - bacteriostatic

35

1st line treatment for bacterial sore throat if centor criteria are met?

Penicillin V

36

What are the 4 TB drugs?

Rifampicin
Isoniazid
Pyrazimide
Ethambutol

37

SE of the TB drugs

Hepatotoxicity

38

Give 2 examples of DNA polymerase inhibitors

Aciclovir, Ganciclovir

39

MoA of Aciclovir

Virus replication blockade via inhibition of DNA polymerase

40

Indication for Aciclovir

Severe chickenpox
Shingles
Herpes encephalitis

41

What class of drug does ritonavir belong to?

Viral protease inhibitor

42

MoA of ritonavir

Blockade of viral protease required for virus particle assembly

43

Give an example of a viral fusion inhibitor

Enfuvirtide

44

MoA of Enfuvirtide

Blockade of virus fusion to target cell membrane

45

What class of drug is Maraviroc?

Viral entry inhibitor

46

MoA of Maraviroc

Blockade of HIV binding to co-factor for cell entry

47

MoA of fluconazole

Disruption of fungal membrance function

48

Name 2 taxanes

Paclitaxel
Docetaxel

49

Give an example of a classical alkylating agent

Cyclophosphamide

50

Give 2 platinum compouds

Cisplatin
Carboplatin

51

MoA of alkylating agents

DNA crosslinking

52

SE of anti-neoplastic drugs

Hair loss
Bone marrow supression
Nausea

53

Name 2 vinca alkaloids

Vincristine
Vinblastine

54

MoA of Taxanes and vinca alkaloids

Inhibition of microtubule assembly in mitotic spindle

55

Name 2 topoisomerase inhibitos

Bleomycin
Etopside

56

MoA of bleomycin

Inhibition of DNA topoisomerase

57

What class do fluorouracil and cytarabine belong to?

Antipyrimidines

58

What class do mercaptopurine and thioguanine belong to?

Antipurines

59

MoA of antipyrimidines and antipurines

Inhibition of RNA and DNA synthesis