Drug deck Flashcards
(59 cards)
What receptors do classical antipsychotics act on?
D2, M1, H1, α1
Give 2 examples of a classical antipsychotic
Haloperidol
Chlorpromazine
Where do atypical antipsychotics act?
5HT2, D2 has some H1, M1 and α1 effects too
Why use atypical antipsychotics?
Better at dealing with negatve symptoms of SCZ also less extrapyrimdal side effects
What is the gold standard antipsychotic?
Clozapine
What condition are patients at risk of with long term classical antipsychotic use?
Tardive dyskinesia
MOA of statins
Inhibition of HMG-CoA reductase resulting in less LDL and a mild increase in HDL
SE of statins
Myopathy
Rhabdomyolysis
MOA of NSAIDs
COX inhibitors leading to reduction in production of prostagladins and thromboxane A2
SE of NSAIDs
Hyperkalaemia Bronchospam Peptic ulcer Hepatotoxic Ototoxicity Reduced GFR
SE of morphine
Respiratory depression
Urinary retention
Constipation
N+V
MOA of COCP
Inhibits ovulation via inhibition of HPG axis via release of oestrogen + progestogen
3 Adv of COCP
Reliable
Reversible
Cycle control
Absoulte CI for COCP (3 of many)
Breastfeeding up to 6 weeks post partum
Up to 3 weeks post-partum with other risk factors for VTE
Age >35 and smoker >15 cigarettes a day
Blood pressure >160/100
Ischaemic heart disease or stroke or vascular disease (ever)
Personal history of DVT (ever)
Thrombogenic mutation (e.g. factor V leiden)
Major surgery with immobilisation
Atrial fibrillation
Migraine with aura within the last 5 years
Breast cancer
MOA of Progesterone contraception
May inhibit ovulation
Thickened and viscid cervical mucus
Endometrium unstable for implantation
Cons of progesterone contraception
Amenorrhoea/ irregular bleeding
Taken at same time each day (cerazette 12 hours)
Increased risk functional ovarian cysts
If did get pregnant increased risk ectopic
What class of antibiotics target the bacterial cell wall?
Beta-lactams - Penicillins, cephalosporins, carbapenems, glycopeptides
What class of antibiotic targets RNA and protein synthesis
Macrolides
Lincosamides
Tetracyclines
Aminoglycosides
What class of antibiotic targets DNA structure and function?
Quinolones
Nitroimidazoles
Nitrofurantoin
What class of antibiotic targets Folic acid synthesis?
Antifolates
Give 4 examples of penicllins
Penicillin
Amoxicillin (enhanced uptake)
Flucloxacillin (penicillinase - resistant
Co-amoxiclav (beta-lactamase inhibitor)
Piperacilin-tazobactam (anti-pseudomonal)
Give 4 examples of cephalosporins
Cephalexin (1st gen)
Cefuroxime (2nd gen)
Cefotaxime (3rd gen)
Ceftriaxone (4th gen)
Give 2 examples of carbapenems
Meropenem
Ertapenem
Give 2 examples of glycopeptides
Vancomycin
Teicoplanin
