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Pharmacology 1 Exam 1 > Drug Disposition- ADME > Flashcards

Drug Disposition- ADME Flashcards

1
Q

What is drug disposition

A

the study of the movement of drugs across biological membranes in the body from the time of absorption until elimination.

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2
Q

what does ADME stand for?

A

Absorption/Distribution/Metabolism/Elimination

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3
Q

the higher the lipid solubility…

A

the easier/ faster it can cross cell membranes

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4
Q

non-ionized molecules cross…

A

lipid membranes more easily / more mobile

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5
Q

The what of a weak acid or base determines in what pH the substance will be ionized

A

the pKa

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6
Q

what does it mean when the pKa = pH

A

the drug is 50% ionized

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7
Q

acidic drugs are ionized in what type of environments?

A

Basic (alkaline, high pH)

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8
Q

Basic drugs are ionized in what type of environments?

A

acidic environments (low pH)

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9
Q

weak acid equals…

A

NI / I

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10
Q

weak base equals…

A

I / NI

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11
Q

antilog -3 equals?

Antilog 3 equals

A 
-3 = 1/1000 or 0.001
3 = 1000/1 or 100
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12
Q

Antilog -2 equals?

Antilog 2 equals?

A 
-2 = 1/100 or 0.01
2 = 100/1 or 100
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13
Q

Antilog -1 equals?

Antilog 1 equals?

A 
-1 = 1/10 or 0.1
1 = 10/1 or 10
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14
Q

antilog 0 equals?

A

1

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15
Q

membranes are more permeable to?

A

non-ionized forms of drugs (lipid) soluble and no electric charges) than to ionized forms

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16
Q

Weak acids are absorbed from an acidic environment and will become sequestered in a more…

A

alkaline ( higher pH) environment

17
Q

weak bases are absorbed from an alkaline environment and will become sequestered in a more…

A

acid (lower pH) environment

18
Q

Facilitated diffusion is..

A

Carrier mediated, saturable, moves with concentration gradient, and does not require energy.

19
Q

Active transport is…

A

Carrier mediated, saturable, selective, and moves substances against the concentration, gradient and requires energy

20
Q

Energy for active transport can be supplied…

A

directly though ATP (primary) or indirectly after ATP is used to create an electrochemical gradient (secondary)

21
Q

what is the term when transporters move two substances together

A

symporter

22
Q

what is the term where on substance is exchanged for another

A

antiporter

23
Q

What is the P-glycoprotein system?

A

specific form of active transport in which the transporter is an efflux pump, this protein is an expression of the MDR-1 gene

24
Q

What does the MDR-1 do?

A

removes drugs after being absorbed into specific cells or tissue sites

25
Q

what is Pinocytosis?

A

a specific type of endocytosis, drugs bind to the surface of the cell then the cell membranes invaginates and interoizes the drug.

Pharmacology 1 Exam 1 (8 decks)

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