Drug Distribution Flashcards
0
Q
Apparent volume of distribution, Vd
A
Q = amount of drug put in the body C = plasma concentration
Vd = Q / C
Apparent volume into which the total drug Q was dissolved to reach the plasma concentration C
The higher the Vd the more the drug has distributed out of the plasma
1
Q
Distribution
A
Drugs distribute to water in tissues, bind to non aqueous components including fat, proteins…
2
Q
PCW
A
Plasma, distribution of hydrophilic groups, high MW
3
Q
ECW
A
Extracellular: plasma plus interstitial
Penetrate capillaries, but not cellular membranes
4
Q
TBW
A
Total body, extracellular plus intracellular
Penetrate cellular membranes, not fat
