Drug doses and routes

Question 1

What is the dose and route of adrenaline in cardiac arrest? Give adult and paediatric doses.

Answer 1

Dose and route:

• Adult (1mg IV)
• Child (0.01mg IV/IO)

Question 2

How often do you give adrenaline in cardiac arrest?

Answer 2

-Every 3-5mins (i.e. every other cycle)

Question 3

What is the dose and route of adrenaline in anaphylaxis? Give adult and paeds (>12, 6-12, 6mo-6yrs and <6months) doses

Answer 3

Adult (0.5mg IM)
Paeds:
->12yrs (0.5mg IM)
-6-12yrs (0.3mg IM)
-Birth-6yrs (0.15mg IM)

Question 4

What is the dose and route of chlorphenamine in anaphylaxis? Give adult and child doses

Answer 4

Adult (10mg IM/IV)
Paeds:
-12yrs-(10mg IM/IV)
-6-12yrs-(5mg IM/IV)
-6mo-6yrs-(2.5mg IM/IV)
-<6mo-(0.0025mg/kg)

Question 5

What is the dose and route of Hydrocortisone in anaphylaxis? Give adult and child doses

Answer 5

Adult (200mg IM/IV)
Paeds: 
-12yrs-(200mg IM/IV)
-6-12yrs-(100mg IM/IV)
-6mo-6yrs-(50mg IM/IV)
-<6mo-(25mg/kg)

Question 6

What is the dose and route of atropine in bradycardia?

Answer 6

0.5mg IV every 1-2mins

Question 7

What is the dose and route of aspirin in in ACS or stroke?

Answer 7

ACS: PO 300mg loading and then 75mg OD
Stroke: PO 300mg for 2 weeks and then 75mg OD

Question 8

What is the dose and route of clopidogrel in ACS?

Answer 8

ACS: PO 300mg loading and then 75mg OD

Question 9

What is the dose and route of calcium gluconate in hyperkalaemia?

Answer 9

10ml of 10% calcium gluconate through slow IV injection

Question 10

What is the dose and route of insulin/dextrose infusion in hyperkalaemia, DKA and HONK?

Answer 10

DKA and HONK:
50U Actrapid in 50ml 0.9 saline-1U/ml +potassium (prevent hypo)
Hyperkalaemia:
10U Actrapid added to 20% glucose (prevent hypo) in 100ml over 15mins

Question 11

Give the route and dose of glucose and glucagon, as treatments for hypoglycaemia.

Answer 11

Glucose-20-30g IV (e.g. 200-300ml of 10%dextrose) 10%=10g/100ml
Glucagon-1mg IV/IM

Question 12

Give the route and doses used for lorazepam and diazepam in status epilepticus.

Answer 12

Lorazepam-IV 2-4mg

Diazepam-infusion with glucose-100mg in 500ml of 5% dextrose

Question 13

What is the dose and route of salbutamol given in acute severe asthma?

Answer 13

5mg nebulised with oxygen

Question 14

What is the dose and route of morphine given in acute coronary syndrome?

Answer 14

-5-10mg IV (repeat after 5mins if necessary)

Question 15

What is the dose and route of naloxone given in opioid overdose?

Answer 15

-0.2-4mg IV

Question 16

What would you give in acute fluid resucitation?

Answer 16

500ml of 0.9% sodium chloride over 15mins