Drug Interactions Flashcards by alyssa cascio

Q

Fluconazole -CNI

A

increase CNI conc

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Q

Phenytoin -CNI

A

Decrease CNI conc

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Q

Echinacea -CNI

A

Decrease CNI conc

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Q

Rifampin-CNI

A

Decrease CNI conc

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Q

Verapamil -CNI

A

Increase CNI conc

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Q

Caspofungin-CNI

A

Decrease CNI conc

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Q

St. John’s wart-CNI

A

decrease CNI conc

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Q

Rifabutin -CNI

A

Decrease CNI conc

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Q

Grapefruit juice-CNI

A

Increase CNI conc

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Q

Ritonavir -CNI

A

Increase CNI conc

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Q

Omeprazole -CNI

A

Increase CNI conc

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Q

Clarithromycin -CNI

A

Increase CNI conc

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Q

Mag & Al -CNI

A

Increase CNI conc

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Q

Terbinafine-CNI

A

Decrease CNI conc

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Q

Carbamazepine-CNI

A

Decrease CNI conc

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Q

Phenobarbital -CNI

A

Decreased CNI conc

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Q

Octreotide-CNI

A

Decrease CNI conc

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Q

Statins-CNI

A

Decreased clearance of statins (increased rhabdo)

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Q

Dabigitran-CNI

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A

Increased exposure

Q

NSAIDS-CNI

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A

Increased nephrotoxicity

Q

Ciprofloxacin-CNI

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A

Increased nephrotoxicity

Q

Ampho B-CNI

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A

Increased nephrotoxicity

Q

Digoxin-CNI

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A

Digoxin toxicity

Q

Diltiazem -CNI

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A

Increase CNI conc

Al & mag- MPA

Decreased MPA absorption

Sevelamer & phosphate binders- MPA

Decreased MPA absorption

PPIs- MPA

Only with MMF | Decreased MPA solubility (decreased absorption )

Acyclovir/ganciclovir-MPA

Concern with decreasing renal function! Monitor

COC- MPA

Decreased efficacy of COC | Need backup

Phenytoin-MPA

Albumin binding may be altered

COC-glucocorticoid

Inhibit glucocorticoid metabolism (higher conc)

Erythromycin & clarithromycin - glucocorticoid

Increased glucocorticoid conc

Ketoconazole - glucocorticoid

Increased glucocorticoid conc

Naproxen -glucocorticoid

Increased glucocorticoid conc

Phenytoin-glucocorticoid

Decreased glucocorticoid conc

Phenobarbital - glucocorticoid

Decreased glucocorticoid conc

Rifampin - glucocorticoid

Decreased glucocorticoid conc

Carbamazepine -glucocorticoid

Decreased glucocorticoid conc

Tacrolimus -glucocorticoid

Decreased tacrolimus conc

Cyclosporine -glucocorticoid

Decreased cyclosporine conc

MPA- glucocorticoid

Decreased MPA conc

Tacrolimus-MPA

Higher MPA AUC

Cyclosporine-MPA

Reduced MPA AUC

Cholestyramine-MPA

Reduced MPA AUC

Antibiotics-MPA

Reduced MPA AUC