Drug List Flashcards

(46 cards)

1
Q

Hemicholinium

A

Stops uptake of choline at neuromuscular junction

Prevent synthesis of acetylcholine

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2
Q

AH5183 (Vesamicol)

A

Stops storage mechanism of acetylcholine at neuromuscular junction

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3
Q

Botulinum toxin (botox)

A

Stops acetylcholine from releasing at neuromuscular junction

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4
Q

Mg2+

A

Block Ca2+ channel

Stops acetylcholine from releasing at neuromuscular junction

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5
Q

Suxamethonium

A

Produce prolonged depolarisation
2 ACh binded together
Depolarising muscle relaxants, used for short period muscle relaxation

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6
Q

Neostigmine

A

Anticholinesterase
Treat myasthenic gravis
Can be used to reverse muscle relaxant effect

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7
Q

Edrophonium

A

Anticholinesterase

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8
Q

Tubocurarine

A

Reversible competitive antagonists of NAChR

Act as muscle relaxants

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9
Q

Vecuronium

A

Reversible competitive antagonists of NAChR

Act as muscle relaxants

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10
Q

Atracurium

A

Reversible competitive antagonists of NAChR

Act as muscle relaxants

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11
Q

Pancuronium

A

Reversible competitive antagonists of NAChR

Act as muscle relaxants

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12
Q

Pilocarpine

A

Muscarinic agonists

Treat glaucoma

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13
Q

Bethanechol

A

Muscarinic agonists
Stimulates gut motility
Assists bladder emptying

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14
Q

Atropine

A

Non-selective muscarinic antagonists
Block secretions, mild tachycardia
Dilates pupil

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15
Q

Hyoscine

A

Muscarinic antagonists
Block mucous secretions
Anti-motion sickness drug

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16
Q

Ipratropium

A
Muscarinic antagonists
Treat asthma (Bronchodilator)
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17
Q

Tolterodine

A

Muscarinic antagonists

Treat urinary incontinence

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18
Q

Hexamethonium

A

Nicotinic antagonists

Anti-hypertensive drug, reduce blood pressure

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19
Q

Trimetaphan

A

Nicotinic antagonists
Lower blood pressure, reduce bleeding
Rarely used in surgery

20
Q

Dyflos

A

Anticholinesterase

Irreversible

21
Q

Parathion

A

Anticholinesterase
Irreversible
Phosphorylate the esteratic site

22
Q

Ecothiopate

A

Anticholinesterase
Irreversible
Phosphorylate the esteratic site
Treat glaucoma

23
Q

Pralidoxime

A

Reative phosphorylated cholinesterase (BChE)

24
Q

a-methyl-p-tyrosine

A

Block tyrosine hydroxylase
Prevent Tyrosine –> L-DOPA
Used in treatment of tumours of adrenal medulla

25
Carbidopa
Block Dopa Decarboxylase (DDC) | Used to treat Parkinson's disease (given with L-Dopa)
26
Reserpine
Block vesicular monoamine transporter (VMAT) Prevent storage of noradrenaline Used as an anti-hypertensive drug (lower blood pressure)
27
Guanthidine
Block release of catecholamines (NA/Adrenaline)
28
Imipramine
Block Uptake 1 Enhance sympathetic neurotransmission Tricycle antidepressants
29
Amitriptyline
Block Uptake 1 Enhance sympathetic neurotransmission Tricycle antidepressants
30
Monoamine oxidase inhibitor
Prevent breakdown of NA / adrenaline | Must alter their diet, prevent high level of tyramine
31
Amphetamine
Displaces NA from storage sites Enter to presynaptic knob by Uptake 1 mechanism Increase NA release
32
Tyramine
Taken up into nerve terminals by NET (Uptake 1) Causes release of cathecolamines Effects are increased by MAO inhibitors
33
Cocaine
Block reuptake transport into nerve terminals (Uptake 2)
34
Imipramine
Block reuptake of NA at nerve endings | Anti-depressive drug
35
Phenylephrine
alpha-1 adrenoceptor agonists | Treat hypotension and nasal congestion
36
Tizanidine
alpha-2 adrenoceptor agonists | Acts as muscle relaxant
37
Isoprenaline
beta-selective adrenoceptor agonists | Used for acute heart block treatment
38
Salbutamol
beta-2 adrenoceptor agonists | Treat asthma
39
Dobutamine
beta-1 adrenoceptor agonists | Increase cardiac output
40
Phenoxybenzamine
Non-selective alpha-adrenoceptor blocker irreversible Used in treatment of phaechromocytoma (adrenal gland tissue tumour)
41
Phentolamine
Non-selective alpha-adrenoceptor blocker Reversible Used in treatment of phaechromocytoma (adrenal gland tissue tumour)
42
Prazosin
alpha-1 block | Used as antihypertensive
43
Labetalol
non-selective beta-adrenoceptor blocker Used to treat stable congestive heart failure Reduce arterial blood pressure
44
Carveldilol
non-selective beta-adrenoceptor blocker Used to treat stable congestive heart failure Reduce arterial blood pressure
45
Propanolol
Selective beta blocker | Treat disturbances of cardiac rhythm, myocardial infarction and angina
46
Metoprolol
Selective beta-1 blocker | Treat disturbances of cardiac rhythm, myocardial infarction and angina