Drug list block 9 Flashcards
Colistin
Polymyxin antibiotic- disrupts bacterial cell wall and change permeability.
Targets gram negative bacteria
Aciclovir
Inhibits viral DNA polymerase
anti viral against Herpes simplex virus inc. shingles
Amanatadine
Inhibits viral ion channel M2 so virus can’t uncut
Anti viral and Parkinson’s drug when paired with L-dopa
Amprenavir
Inhibits HIV-1 protease to stop protein cleavage
HIV drug
Zidovudine
Nucleoside reverse transcriptase inhibitor
HIV drug
Clotrimazole
Inhibits demethylase to stop conversion of lanosterol to ergosterol for fungal cell walls
Anti-fungal
Nystatin
Binds to ergosterol in fungal cell membranes and makes holes
Anti-Fungal
Pyrimethamine
Folate antagonist
Anti-parasitic- malaria, toxoplasmosis
Quinine
In habits haem polymerase in parasite
Anti-parastitic- Malaria
Artemether
Interacts with haem in parasite- peroxide.
Anti-malarial.
Given with lumefantrine as that has a longer half life
Griseofulvin
Inhibits fungal mitosis
Clobetasone
Upregulates lipocortins and inhibits thromboxane and cox enzymes.
Glucocorticoid- high potency topical cream
Dacarbazine
Alkylating agent chemotherapy for lymphoma and leukaemia
Cyclophosphamide
Alkylating agent chemotherapy for lymphoma and leukaemia
Rituximab
Monoclonal antibody causes B cell lysis by being an antibody against CD20 antigen on normal and malignant B cells
Used for rheumatoid arthritis with methotrexate
For non-hodgkins lymphoma and CLL
Doxorubicin
Anthracycline chemotherapy than inhibits topoisomerase II
Used for most solid tumours
Paclitaxel
Taxoid chemotherapy- bind to beta subunit of microtubules to hyper stabilise them so can’t reorganise and under cell division.
For ovarian and breast cancer
Tamoxifen
SERM
Decreases oestrogen response
Used in breast cancer
5-Flurouracil
Antimetabolite- pyrimidine analogue chemotherapy.
S phase specific
Breast, colon, stomach and head and neck cancer
Etoposide
DNA topoisomerase inhibitor chemotherapyUsed for lung and testicular cancer
Vinblastine
Tubulin polymerase inhibitor chemotherapy.
Inhibits mitosis at metaphase.Used for bladder, breast, kidney and testicular cancer
Tretinoin
Binds to RAR’s linked in APL to reduce proliferation.
A vitamin A analogue
Used for acne and acute promyelolitic leukaemia
