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Renal > Drug Mechanisms, Toxicities, Utility > Flashcards

Drug Mechanisms, Toxicities, Utility Flashcards

1
Q

Spironolactone & eplerenone toxicities

A

hyperkalemia
gynecomastia
antiandrogen

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2
Q

Thiazides are used for

A
  1. HTN
  2. CHF
  3. Idiopathic hypercalcinuria
  4. Nephrogenic DI
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3
Q

Thiazide toxicity includes

A

hypokalemia, hyponatremia, metabolic alkalosis

hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia

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4
Q

Thiazide mechanism

A

inhibit Na/Cl cotransporter in theDCT

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5
Q

ACE inhibitor toxicity

A 
Cough
Angioedema
Teratogen
Creatinine increase
Hyperkalemia, hypotension
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6
Q

Mannitol mechanism

A

Osmotic diuretic that increases tubular fluid osmolarity in PCT

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7
Q

Mannitol toxicity

A

Pulmonary edema, intravascular dehydration

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8
Q

Acetazolamide mechanism

A

carbonic anhydrase inhibitor blocks reabsorption of bicarb in PCT

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9
Q

Acetazolamide mechanism

A
  1. weak diuretic
  2. alkalinize urine
  3. glaucoma
  4. metabolic alkalosis
  5. altitude sickness
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10
Q

acetazolamide toxicities

A
  1. hyperchloremic metabolic acidosis
  2. hypokalemia
  3. NH3 toxicity
  4. neuropathy
  5. sulfa allergy
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Renal (22 decks)

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