Drug metabolism

Question 1

Phase I of drug metabolism?

Answer 1

Makes drugs more polar via:

-oxidation. reduction or hydrolysis

Question 2

Phase II of drug metabolism?

Answer 2

Conjugates the drug, making it polar

Question 3

What reactions do the Cytochrome P450 (CYP) Monooxygenases catalyse?

Answer 3

Oxidation reactions of Phase I drug metabolism

Question 4

What enzyme is involved in glucoronidation, a Phase II metabolism reaction?

Answer 4

UDP-glucoronyl transferase

Question 5

What are the transporter systems involved in the Tubular Secretion of Drugs at the nephron?

Answer 5

1. Organic Anion Transporter (OAT)

2. Organic Cation Transporter (OCT)