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Clinical Pharmacology > Drug Metabolism Flipped > Flashcards

Drug Metabolism Flipped Flashcards

(63 cards)

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1
Q

ADs: fluoxetine, sertraline, duloxetine, paroxetine, bupropion

A

2D6 inhibitor

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2
Q

Amiodarone

A

inhibits: 1A2, 2C8/9, 2D6, 3A4, Pgp
substrate: 3A4, Pgp

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3
Q

Apixaban/rivaroxaban

A

3A4 substrate

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4
Q

Atorvastatin/simvastatin

A

substrate: 3A4, Pgp

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5
Q

Atypical antipsychotics (aripiprazole, risperidone)

A

substrate: 2D6, 3A4

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6
Q

BZDs

A

substrate: 3A4

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7
Q

Carbamazepine

A

substrate: 3A4

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8
Q

Carbamazepine/phenytoin

A

inducer: 1A2, 2C8/9, 2C19, 3A4, Pgp
substrate: Pgp

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9
Q

Carvedilol

A

substrate: 2C8/9
inhibitor: Pgp

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10
Q

CCBs (amlodipine, verapamil, diltiazem)

A

substrate: 3A4

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11
Q

Cimetidine

A

inhibitor: 1A2, 2C19, 2D6, 3A4

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12
Q

Ciprofloxacin

A

inhibitor: 1A2

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13
Q

Citalopram

A

substrate: 2C19

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14
Q

Clarithromycin

A

substrate: 3A4
inhibitor: 3A4, Pgp

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15
Q

Clopidogrel

A

substrate: 2C19
inhibitor: 2C8/9

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16
Q

Codeine

A

substrate: 2D6

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17
Q

Cyclosporine, tacrolimus, siroliumus

A

substrate: 3A4

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18
Q

Dabigatran/rivaroxaban

A

substrate: Pgp

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19
Q

Dexamethasone

A

inducer: Pgp

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20
Q

Digoxin

A

substrate: Pgp

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21
Q

Diltiazem

A

substrate: Pgp

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22
Q

Diltiazem/verapamil

A

inhibitor: 3A4, Pgp

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23
Q

Duloxetine

A

substrate: 1A2

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24
Q

Estrogen

A

substrate: 3A4, Pgp
inhibitor: 1A2

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25
Fluconazole
inhibitor: 2C8/9, 2C19, 3A4
26
Fluoxetine
inhibitor: 2C19
27
Fluoxetine, paroxetine, duloxetine
substrate: 2D6
28
Gemfibrozil
inhibitor: 2C19
29
Gemfibrozil/fenofibrate
inhibitor: 2C8/9
30
Grapefruit Juice
inhibitor: 3A4
31
Many chemo
substrate: Pgp
32
Metoprolol
substrate: 2D6
33
Metronidazole
inhibitor: 2C8/9
34
Most PPI (omeprazole)
substrate: 2C19
35
Non DHP CCBs (verapamil, diltiazem)
inhibitor: 3A4
36
OCPs
substrate: 3A4
37
Omeprazole
substrate: Pgp
38
Omeprazole/esomeprazole
inhibitor: 2C19
39
Opioids (hydrocodone, oxycodone)
substrate: 3A4
40
Paroxetine/sertraline
substrate: Pgp
41
PDE5 inhibitors (sildenafil, tadalafil, vardenafil)
substrate: 3A4
42
Phenytoin
substrate: 2C8/9, 2C19
43
Pioglitazone
substrate: 2C8/9
44
PIs (ritonavir)
3A4 substrate, inhibitor
45
Rifampin
inducer: 1A2, 2C8/9, 2C19, 3A4, Pgp
46
Smoking
inducer: 1A2
47
SSRI (citalopram, paroxetine, sertraline)
substrate: 3A4
48
St. Johns Wort
inducer: 2C8/9, 2C19, 3A4, Pgp
49
TCAs
substrate: 1A2, 2C8/9, 2C19, 2D6
50
THC
inducer: 1A2
51
Theophylline
substrate: 1A2, 3A4
52
TMP-SMX
inhibitor: 2C8/9
53
Valproate
inhibitor: 2C8/9
54
Warfarin
substrate: 2C8/9
55
Mirtazepine
substrate: 1A2, 2D6, 3A4
56
Melatonin Receptor Agonist
substrate: 1A2, 3A4
57
Conventional Antipsychotics (chlorpromazine, haloperidol)
2D6 substrate/inhibitor; 3A4 substrate
58
Atomoxetine
2D6 substrate
59
Buspirone
3A4 substrate
60
Venlafaxine
2D6, 3A4 substrate
61
Trazodone
3A4 substrate, Pgp inducer
62
NBRA (zolpidem, eszopiclone)
3A4 substrate
63
Celecoxib
2C9 substrate

Clinical Pharmacology (54 decks)

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