Drug MOA/ conditions used for Flashcards
(21 cards)
Denosumab
Monoclonal RANKL (competitive inhibitor) Ab GCT and osteoporosis
Etanarcept Inflixaimab Adalimumab
TNF a antagonist RA
Abatacept
MHC receptor antagonist RA
TXA
Synthetic lysine analog Competitively blocks plasmin activation from plasminogen
Fondaparinux
Indirect Factor Xa inhibitor
Dabigatran
Thrombin inhibitor
Heparin & lovenox
Activates Antithrombin 3 which then blocks factors X and Thrombin
Apixaban
Factor Xa inhibitor
Rivaroxaban
Direct Factor Xa inhibitor
Warfarin
Blocks Vit K reductase- blocking factors 2, 7, 9, 10 and proteins C&S
tPA & streptokinase
Increases plasmin which breaks down fibrin clots
Rituximab
CD20 (B cells) Monoclonal Ab Used w/ methotrexate for RA resistant to TNF-a blockers
TXA
Stabilizes fibrin clot by block plasminogen activation
Penicillin/ cephalosporins
beta- lactam
MOA- inhibits cell wall cross-linking
Resistance= beta- lactamase
Aminoglycosides (gentamycin, tobramycin)
Inhibit protein synthesis (30s subunit)
Used for G (-)/ polymicrobial infections
Side effects- hearing, renal toxicity and neuromuscular blockade
Macrolides (clinda, erythro, azithro, clarithro)
Inhibits dissociation of peptidyl-transfer RNA from ribosomes (binds 50s)
Clinda= bacteriostatic; G (+) & anaerobes; side effects- enterocolitis
Tetracycline
Inhibit protein synthesis (binds 50s)
Stains teeth in kids (contraindicated < 8yo)
Rifampin
Blocks RNA polymerase F
Quinolones
Blocks DNA gyrase
Side effects- tendon rupture
Oxazolidinones (linezolid)
Binds 50s to inhibit protein synthesis
Botox
blocks ACh release by cleaves pre-synaptic SNAREs
Raynaud
