Drug MOAs

Question 1

Dipyridamole

Answer 1

non-specific phosphodiesterase inhibitor and decreases cellular uptake of adenosine

Question 2

Pilocarpine

Answer 2

muscarinic receptor agonist - it increases uveoscleral outflow by constricting the pupil.

Question 3

Amiodarone

Answer 3

class III antiarrhythmic agent used to treat atrial, nodal and ventricular tachycardias
blocks K+ channels which inhibits repolarisation and hence prolongs the action potential

Question 4

Drugs which exhibit zero-order kinetics

Answer 4

Zero-order kinetics - the rate of excretion being constant, regardless of changes in plasma concentration of the drug

Phenytoin
Aspirin
Alcohol

Question 5

What type of receptors does Levothyroxine work on?

Answer 5

Nuclear

Question 6

MOA of Acyclovir

Answer 6

Inhibits viral DNA polymerase
Guanosine analogue

Question 7

MOA of anastrozole / letrozole

Answer 7

Aromatase inhibitors
Reduce peripheral oestrogen synthesis
SE - osteoporosis

Question 8

MOA of ocreotide

Answer 8

Long acting analogue of somatostatin
Released from D cells of the pancreas
Inhibits the release of GH, glucagon and insulin

Question 9

Propylthiouracil MOA

Answer 9

inhibits the production of new thyroid hormone in the thyroid gland. [2] It acts by inhibiting the enzyme thyroid peroxidase, which usually converts iodide to an iodine molecule and incorporates the iodine molecule into amino acid tyrosine