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Pharmacology > Drug Profiles: Winter quiz 2 > Flashcards

Drug Profiles: Winter quiz 2 Flashcards

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1
Q

Ketorolac: indications

A

mild to moderate pain

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2
Q

Calcium Chloride: pharmacokinetics

A

onset: immediate peak: immediate

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2
Q

Calcium Gluconate: side effects

A

Tissue necrosis if given subcutaneously, or if it extravasates.

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3
Q

Droperidol: dosage

A

14-60 y/o: 2.5-5 mg IV/IM (may be combined with 2 mg midazolam in same syringe for increased sedation), may be repeated once as needed. Over 60 y/o: 2.5 mg IV/IM (with or without midazolam). Not recommended as first-line N&V med because of “black box” warning from FDA.

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4
Q

Sodium Bicarbonate: contraindications

A

none prehospital setting

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5
Q

Promethazine: side effects

A

Drowsiness, sedation, blurred vision, tachycardia, bradycardia, and dizziness

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6
Q

Magnesium Sulfate: interactions

A

may block effects of digitalis

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7
Q

Calcium Chloride: interactions

A

Will precipitate if mixed with sodium bicarbonate.

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8
Q

Calcium Gluconate: precautions

A

Use with caution in patients with potential to digoxin toxicity. Consider contacting OLMC.

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9
Q

Ketorolac: mechanism of action

A

NSAIDs inhibit cyclooxygenase and prevent the synthesis of prostaglandins and thromboxane, which reduce inflammation and ultimately provide pain relief.

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10
Q

Diphenhydramine: class

A

antihistamine; H1 antagonist

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11
Q

Droperidol: indications

A

Chemical restraint requiring rapid tranquilizationn, anti-emetic.

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12
Q

Calcium Gluconate: dosage

A

10-30 ml slow IV. topical application inside surgical glove (gel or not) for finger/ thumb/ hand fluoride burns. 10 ml vile of 10% calcium gluconate contains 4.6 mEq of calcium.

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12
Q

Haloperidol: contraindications

A

Hypotension, prolonged QT interval

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12
Q

Promethazine: precautions

A

May impair mental and physical abilities. Never give subcutaneously. Extra-pyramidal symptoms have been reported following use. Diphenhydramine should be available.

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13
Q

Calcium Chloride: dosage

A

5-10 ml slow IVP. 10 ml of 10% solution contains 13.6 mEq of calcium

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13
Q

Droperidol: precautions

A

BP and respiratory status should be monitored frequently. If used for chemical restraint, patient should be restrained in a fashion that allows careful observation and the ability to breathe normally. Cardiac monitoring is required as the FDA has issued a “black box” warning stating that Droperidol may cause torsades de pointes.

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14
Q

Calcium Chloride: class

A

electrolyte

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15
Q

Droperidol: mechanism of action

A

Exact mechanism of action is unknown, but main action is antagonism of the dopamine (D2) within the CNS. Neuroleptic similar to haloperidol; reduces anxiety and produces a mental state of detachment and indifference; as anti-emetic and anti-nausea properties.

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16
Q

Ondansetron: indications

A

Uncontrollable nausea and vomiting

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17
Q

Diphenhydramine: interactions

A

Sedation in presence of CNS depressants

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18
Q

Acetaminophen: mechanism of action

A

Produces analgesia by blocking generation of pain impulses probably by inhibition of prostaglandin synthesis. It relieves fever by central chain action in the hypothalamus heat regulating center.

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19
Q

Fentanyl Citrate: precautions

A

Monitor respiratory status. Naloxone will reverse the effects of fentanyl.

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20
Q

Magnesium Sulfate: mechanism of action

A

increases the magnesium levels, correcting for possible hypomagnesemia, which is associated with cardiac dysrhythmias. Magnesium interferes with neuromuscular transmission, which reduces muscle contractions in seizures. Additionally magnesium is a smooth muscle relaxer and vasodilator. The MOA’s of magnesium for all indications are complex and multifactorial, and therefore, not well understood.

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20
Magnesium Sulfate: contraindications
hypotension, heart block
20
Acetaminophen: side effects
none
21
Droperidol: contraindications
Hypotension, prolonged QT interval
23
Sodium Bicarbonate: dosage
1 milliequivalent/kg IVP
24
Diphenhydramine: pharmacokinetics
Onset: \< 2 minutes IV; 15-30 minutes IM Peak: 5 minutes IV; 20 minutes IM Duration: 5-10 minutes IV; 20-30 minutes IM
25
Fentanyl Citrate: note
100 mcg fentanyl equals 10 mg morphine. Schedule II narcotic.
25
Acetaminophen: indications
fever
26
Calcium Chloride: side effects
Tissue necrosis if given subcutaneously, or if it extravasates. Because calcium chloride contains approximately 3 times as much calcium as calcium gluconate, it is far more irritating to blood vessels.
26
Diphenhydramine: mechanism of action
Antagonizes central and peripheral H1 receptors, which decreases the itching and urticaria caused by histamine release. Additionally, possesses anticholinergic properties, resulting in anti-dyskinetic, anti-emetic and sedative effects.
26
Diphenhydramine: indications
Allergic and anaphylactic reactions. Dystonic reactions/extra-pyramidal symptoms (from phenothiazines, thioxanthins, and butyrophenones.
27
Calcium Gluconate: indications
Hyperkalemia, CCB OD, hypotension associated with magnesium sulfate or calcium channel blocker administration, and hydrofluoric acid burns.
28
Fentanyl Citrate: side effects
Drowsiness, hypotension, bradycardia, and respiratory depression are the most common, however it may cause nausea and vomiting, weakness, and dizziness, increased excitability (paradoxical)
28
Haloperidol: indications
Chemical restraint requiring rapid tranquilization
30
Sodium Bicarbonate: side effects
few in prehospital setting
32
Calcium Chloride: precautions
Use with caution in patients with potential digoxin toxicity. Consider contacting OLMC.
32
Haloperidol: precautions
BP and respiratory status should be monitored frequently. Patients should be restrained in a fashion that allows careful observation and the ability to breathe normally. Cardiac monitoring is required
34
Fentanyl Citrate: contraindications
Severe hemorrhage and shock. Patients who have taken MAOIs (Marplan, Eutonyl, Parnate, Nardil) within the last 14 days should avoid fentanyl. Severe and then predictable potentiation is possible. Use with caution, if at all in any patient with a head injury (except during RSI). If the patient's mentation becomes altered after administration, assessment of the head injury because more difficult in the ED.
36
Calcium Gluconate: pharmacokinetics
onset: immediate peak: immediate
37
Ketorolac: precautions
Use cautiously, if at all, in patients with renal or hepatic disease.
38
Ondansetron: dosage
4 mg slow IVP/IM
39
Haloperidol: side effects
Extra-pyramidal or dystonic reactions, frequently given concurrently with diphenhydramine.
40
Haloperidol: interactions
Anti-hypertensive medications may increase the likelihood of a patient developing hypotension. haloperidol potentiates other CNS depressants
41
Fentanyl Citrate: interactions
Other CNS depressants enhance the opioid action, resulting in decreased LOC, hypotension, and respiratory depression. Careful monitoring is required.
42
Promethazine: contraindications
Coma, those who have received large amounts of depressants, nursing mother, neonate.
43
Droperidol: class
Sedative, butyrophenone anti-psychotic
44
Promethazine: class
Antihistamine and anti-emetic, phenothiazine anti-psychotic
45
Sodium Bicarbonate: precautions
Patients must be breathing spontaneously or adequately ventilated before receiving sodium bicarbonate.
46
Magnesium Sulfate: dosage
Cardiac arrest: 1-2 g IVP Torsades de pointes (with pulse): 1-2 g IV drip 5-60 minutes Preeclampsia and eclampsia: 2 g IV drip 5-60 minutes
47
Diphenhydramine: contraindications
None in acute prehospital use
48
Magnesium Sulfate: side effects
hypotension, respiratory depression, flushing, loss of deep tendon reflexes.
49
Fentanyl Citrate: pharmacokinetics
Onset: \< 1 minute IV Duration: 30-60 minutes
51
Calcium Gluconate: mechanism of action
Calcium antagonizes cardiotoxicity of hyperkalemia by stabilizing cardiac cell membrane against undesirable depolarization. Soluble calcium ions bind with sodium fluoride ions to produce the insoluble and therefore inactive calcium fluoride salt.
52
Diphenhydramine: precautions
Altered mental status, asthma, nursing mothers
53
Promethazine: dosage
N&V: 12.5-25 mg IV/IM Analgesic adjunctive: 25 mg IV
54
Haloperidol: dosage
2-5 mg IM (may be combined with midazolam)
55
Diphenhydramine: dosage
Adult: 25-50 mg IV/IM/PO Pediatric: 1 mg/kg up to adult dose
57
Ketorolac: class
non-steroidal anti-inflammatory agent
58
Sodium Bicarbonate: note
mass actually effect = H2O + CO2 \<\> H2CO3 \<\> H+ +HCO3-
59
Acetaminophen: OD management
Early symptoms are sweating, anorexia, nausea or vomiting, abdominal pain or cramping and/or diarrhea; usually in 6-14 hours after ingestion, lasting up to 24 hours. Late symptoms include abdominal swelling (ascites), tenderness or pain 2-4 days post exposure. Give activated charcoal \> 2 hours post ingestion. The patient will require N-acetylcysteine and will need serum acetaminophen levels determined at the ED.
60
Droperidol: side effects
Extra-pyramidal or dystonic reactions, especially in children. Diphenhydramine should be available.
61
Promethazine: pharmacokinetics
Onset: 3-5 minutes
62
Droperidol: interactions
Anti-hypertensive medications may increase the likelihood of a patient developing hypotension. Droperidol potentiates other CNS depressants.
64
Ketorolac: contraindications
allergy to any NSAID
65
Promethazine: mechanism of action
Blocks receptors for dopamine (D2), acetylcholine, and histamine (H1). All three of these neurotransmitter sites are implicated in the vomiting reflex, so thought to be involved in promethazine anti-emetic effects. Sedative effect is thought to be mostly related to antihistamine properties. EPS (adverse effects) are thought to be mostly related to dopamine antagonism.
66
Acetaminophen: dosage
Adult: 650-1000 mg PO Pediatric: 10-20 mg/kg
67
Haloperidol: class
Sedative, neuroleptic, butyrophenone anti-psychotic
68
Calcium Gluconate: interactions
Will precipitate if mixed with sodium bicarbonate.
69
Fentanyl Citrate: class
opioid analgesic (narcotic)
70
Sodium Bicarbonate: class
alkalinizing agent
70
Ondansetron: mechanism of action
Selective inhibitor of serotonin (5-HT3) receptors
71
Ondansetron: class
Anti-emetic
73
Fentanyl Citrate: indications
Moderate to severe pain, adjunct in rapid sequence induction (intubation).
75
Droperidol: pharmacokinetics
Onset: 3-10 minutes IV/IM
76
Acetaminophen: contraindications
none in prehospital setting
77
Haloperidol: mechanism of action
Not well understood but blocks dopamine (D2) receptors in brain; produces marked tranquilization and sedation.
79
Ketorolac: side effects
increased risk of bleeding, especially given with other NSAIDs.
80
Calcium Gluconate: class
electrolyte
81
Acetaminophen: precautions
Many nonprescription products contain acetaminophen, consider this when calculating dosage.
82
Sodium Bicarbonate: indications
TCA OD, late in the management of cardiac arrest, if at all. Hyperkalemia (controversial)- routine use of sodium bicarbonate for hyperkalemia is falling out of favor, but it is still present in some protocols.
83
Fentanyl Citrate: mechanism of action
Binds to various opioid receptors, producing analgesia and sedation (opioid agonist).
85
Magnesium Sulfate: indications
Torsades de pointes, cardiac arrest only if torsades de pointes is present or was the rhythm that preceded VF or if hypomagnesemia is suspected, preeclampsia and eclampsia, refractory bronchoconstriction, TCA OD (if QRS is wide) (controversial)- no longer universally thought to be effective for TCA ODs, but still in some protocols.
86
Sodium Bicarbonate: interactions
Deactivates catecholamines, forms precipitate with calcium chloride (if sodium bicarbonate is given before or after any of these drugs, flushed the IV line to prevent interactions)
87
Ondansetron: contraindications
None known, use with caution in setting of bowel obstruction.
88
Fentanyl Citrate: dosage
2 mcg/kg IV/IO/IM, usually up to 100 mcg
89
Acetaminophen: class
antipyretic, non-narcotic analgesic
90
Acetaminophen: how supplied
PO or rectal suppositories
91
Magnesium Sulfate: precautions
calcium chloride is antidote if respiratory depression ensues, caution in renal failure patients.
92
Ketorolac: dosage
60 mg IM or 30 mg IV (decreased dose by 1/2 if \> 65 y/o)
93
Sodium Bicarbonate: mechanism of action
When disassociated, bicarbonate binds with hydrogen ions to decrease metabolic acidosis (mass action effect). When administered for TCA overdose, acts as an anti-dysrhythmic. It is unlikely that sodium bicarbonate decreases the effects of hyperkalemia by shifting potassium into cells as has been previously thought. However sodium bicarbonate can still be useful in the treatment of hyperkalemia, since this condition is frequently accompanied by metabolic acidosis.
94
Promethazine: indications
Nausea and vomiting, motion sickness, and sedation (to potentiate the effects of analgesics).
95
Calcium Chloride: mechanism of action
Calcium antagonizes cardiotoxicity of hyperkalemia by stabilizing cardiac cell membrane against undesirable depolarization. Soluble calcium ions bind with soluble fluoride ions to produce the insoluble and therefore inactive calcium fluoride salt.
96
Diphenhydramine: side effects
Anticholinergic effects. Most common are constipation, decreased sweating, difficulty in initiating urine stream, visual disturbances, photosensitivity, and dry mouth.
97
Calcium Chloride: indications
Hyperkalemia, CCB OD, hypotension associated with magnesium sulfate or calcium channel blocker administration, and hydrofluoric acid burns.
98
Acetaminophen: interactions
Increased risk of hepatic damage if patient has ingested ethanol.
99
Magnesium Sulfate: class
electrolyte, anti-dysrhythmic

Pharmacology (24 decks)

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