Drug Quiz 4

Question 1

hydrocodone bitartrate with acetaminophen
Brand?
TC?
MOA?
AE?

Answer 1

Brand: Lortab, Vicodin, Norco
TC: opioid analgesi
MOA: acetaminophen - inhibiting prostaglandin synthesis; hydrocodone - opioid analgesic, action on central opiate receptors
AE: constipation, dizziness, drowsiness

Question 2

oxycodone with acetaminophen
Brand?
TC?
MOA?
AE?

Answer 2

Brand: Percocet, Roxicet, Endocet
TC: opioid analgesic
MOA: acetaminophen - inhibiting prostaglandin synthesis, opioid analgesic, action on central opiate receptors
AE: constipation, dizziness, drowsiness

Question 3

oxycodone
Brand?
TC?
MOA?
AE?

Answer 3

Brand: Oxycontin, Roxicodone
TC: opioid analgesic
MOA: opioid analgesic, action central opiate receptors
AE: constipation, somnolence

Question 4

morphine (extended release)
Brand?
TC?
MOA?
AE?

Answer 4

Brand: MS Contin
TC: opioid analgesic
MOA: opioid analgesic, action on central opiate receptors
AE: constipation, lightheadedness

Question 5

fentanyl (transdermal)
Brand?
TC?
MOA?
AE?

Answer 5

Brand: Duragesic
TC: opioid analgesic
MOA: opioid analgesic, action on central opiate receptors (u)
AE: hypoventilation, hypotension

Question 6

acetaminophen with codeine
Brand?
TC?
MOA?
AE?

Answer 6

Brand: Tylenol (with Codeine)
TC: opioid analgesic
MOA: acetaminophen - inhibiting prostaglandin synthesis, Codeine - weak opioid agonist, (u) opiate receptors
AE: constipation, dizziness, drowsiness, sweating

Question 7

hydromorphone
Brand?
TC?
MOA?
AE?

Answer 7

Brand: Dilaudid
TC: opioid analgesic
MOA: opioid agonist, action on central opiate receptors
AE: constipation, respiratory depression

Question 8

methadone
Brand?
TC?
MOA?
AE?

Answer 8

Brand: Methadone
TC: opioid analgesic
MOA: opioid analgesic, action on central opiate receptors
AE: dizziness, drowsiness, lightheadedness, sweating

Question 9

oxymorphone
Brand?
TC?
MOA?
AE?

Answer 9

Brand: Opana
TC: opioid analgesic
MOA: opioid analgesic, action on central opiate receptors
AE: constipation, respiratory depression

Question 10

buprenorphine with naloxone
Brand?
TC?
MOA?
AE?

Answer 10

Brand: Suboxone
TC: opioid dependence agent
MOA: buprenorphine - partial opioid agonist MU/antagonist KAPPA. naloxone - antagonist at mu-opioid

Question 11

donepezil
Brand?
TC?
MOA?
AE?

Answer 11

Brand: Aricept
TC: Alzheimer’s dementia agent
MOA: acetylcholinesterase inhibitor (increase amount of acetylcholine available at cholinergic synapses)
AE: Steven Johnsons Syndrome, QTC prolongation, rhabdomyolysis

Question 12

memantine
Brand?
TC?
MOA?
AE?

Answer 12

Brand: Namenda
TC: Alzheimer’s dementia agent
MOA: NMDA receptor antagonist (weak to moderate)
AE: dizziness, headache, hallucination

Question 13

benztropine
Brand?
TC?
MOA?
AE?

Answer 13

Brand: Cogentin
TC: antiparkinson agent
MOA: inhibitor of both cholinergic/histamine receptors
AE: dry mouth, blurry vision, numbness

Question 14

carbidopa with levodopa
Brand?
TC?
MOA?
AE?

Answer 14

Brand: Sinemet (CR)
TC: antiparkinson agent
MOA: carbidopa - inhibits dopa-decarboxylase, (increase Levodopa levels), levodopa - converts to dopamine
AE: dystonia/involuntary movements, dementia

Question 15

pramipexole
Brand?
TC?
MOA?
AE?

Answer 15

Brand: Mirapex
TC: antiparkinson agent
MOA: nonergot dopamine receptor agonist
AE: dizziness, somnolence, asthenia

Question 16

ropinirole
Brand?
TC?
MOA?
AE?

Answer 16

Brand: Requip (XL)
TC: antiparkinson agent
MOA: dopamine D2/D3 agonist
AE: somnolence, dizziness, syncope

Question 17

aripiprazole
Brand?
TC?
MOA?
AE?

Answer 17

Brand: Abilify
TC: antipsychotic
MOA: unknown (agonist of D2 and 5HT1A/antagonist of 5-HT2A)
AE: tardive dyskinesia, anxiety

Question 18

lurasidone
Brand?
TC?
MOA?
AE?

Answer 18

Brand: Latuda
TC: antipsychotic
MOA: unknown(antagonism of dopamine D2 and serotonin 5HT2 receptors)
AE: neuroleptic malignant syndrome, tardive dyskinesia

Question 19

olanzapine
Brand?
TC?
MOA?
AE?

Answer 19

Brand: Zyprexa
TC: antipsycotic
MOA: unknown (antagonism of dopamine D2 and serotonin 5HT2 receptors), inhibitor of muscarinic/histamine/adrenergic alpha 1 receptors
AE: somnolence, agitation, insomnia

Question 20

quetiapine
Brand?
TC?
MOA?
AE?

Answer 20

Brand: Seroquel
TC: antipsychotic
MOA: multiple neurotransmitter antagonist (5HT1, 5HT2, dopamine 1/D2, histamine 1, adrenergic alpha 1/2 receptors)
AE: somnolence, hypotension, dry mouth

Question 21

risperidone
Brand?
TC?
MOA?
AE?

Answer 21

Brand: Risperdal
TC: antipsychotic
MOA: unknown (antagonism of dopamine D2 and serotonin 5HT2 receptors)
AE: extrapyramidal symptoms, tachycardia, priapism, rash

Question 22

ziprasidone
Brand?
TC?
MOA?
AE?

Answer 22

Brand: Geodon
TC: antipsychotic
MOA: unknown (antagonism of dopamine D2 and serotonin 5HT2 receptors)
AE: drowsiness, heart arrhythmias, dizziness

Question 23

amphetamine and dextroamphetamine salts
Brand?
TC?
MOA?
AE?

Answer 23

Brand: Adderall (XR)
TC: CNS agent for ADHD
MOA: unknown (CNS stimulation on adrenergic receptors, releasing NE)
AE: restlessness, insomnia

Question 24

methylphenidate (IR and ER)
Brand?
TC?
MOA?
AE?

Answer 24

Brand: Ritalin, Methylin, Metadate, Concerta
TC: CNS agent for ADHD
MOA: activates the brain stem arousal system and cortex
AE: nervousness, insomnia, palpitations

Question 25

``` dexmethylphenidate Brand? TC? MOA? AE? ```

Answer 25

Brand: Focalin (XR) TC: CNS agent for ADHD MOA: unknown (central nervous system stimulant) AE: dry mouth, anxiety, insomnia

Question 26

``` lisdexamfetamine Brand? TC? MOA? AE? ```

Answer 26

Brand: Vyvanse TC: CNS agent for ADHD MOA: unknown (CNS stimulation on adrenergic receptors, releasing NE) AE: decreased appetite, insomnia, dry mouth

Question 27

``` atomoxetine Brand? TC? MOA? AE? ```

Answer 27

Brand: Strattera TC: CNS agent for ADHD MOA: unknown (inhibition of pre-synaptic norepinephrine transporter) AE: mood swings, dry mouth, insomnia

Question 28

``` guanfacine Brand? TC? MOA? AE? ```

Answer 28

Brand: Intuniv TC: antihypertensive/ADHD MOA: stimulates central alpha-2 adrenergic receptors AE: drowsiness, weakness, dry mouth