Drug Reactions

Question 1

Coronary Vasospasm

Answer 1

Cocaine, Sumatriptan, ergot alkaloids

Question 2

Cutaneous Flushing

Answer 2

VANComycin, Adenosine, Niacin, Ca Channel blockers

“VANC”

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicine (Adriamycin), Daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III potassium channel blockers (sotalol), Class IA sodium channel blockers (quinidine), macrolides, haloperidol, chloroquine, protease inhibitors

Question 5

Agranulocytosis

Answer 5

Cloazpine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

Question 6

Aplastic anemia

Answer 6

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

Question 7

Thrombocytopenia

Answer 7

Heparin (HIT), cimetidine

Question 8

Direct coombs positive hemolytic anemia

Answer 8

methyldopa, penicillin

Question 9

Gray baby syndrome

Answer 9

Chloramphenicol

This is due to the baby having immature UDP glucuronidase, so the drug can’t be metabolized appropriately

Question 10

Hemolysis in G6PD-deficienct patient

Answer 10

Isoniazid, Sulfonazmides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

“hemolysis IS PAIN”

Question 11

Megaloblastic anemia

Answer 11

Phenytoin, Methotrexate, Sulfa drugs

“having a BLAST with PMS”

Question 12

Thrombotic complications

Answer 12

OCPs

Question 13

Cough

Answer 13

ACE inhibitors

Question 14

Pulmonary fibrosis

Answer 14

Bleomycin, Amiodarone, Busulfan

Question 15

Acute cholestatic hepatitis, jaundice

Answer 15

Erythromycin

Question 16

Focal to massive hepatic necrosis

Answer 16

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (high doses)

“liver HAVAc”

Question 17

Hepatitis

Answer 17

Isoniazid

Question 18

Pseudomembranous colitis

Answer 18

Clindamycin, ampicillin

Question 19

Adrenocortical insufficiency

Answer 19

Glucocorticoid withdrawal

Question 20

Gynecomastia

Answer 20

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole

“Some Drugs Create Awkward Knockers”

Question 21

Hot flashes

Answer 21

Tamoxifen, clomiphene

Question 22

Hyperglycemia

Answer 22

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 23

Hypothyroidism

Answer 23

Lithium, amiodarone, sulfonamides

Question 24

Fat redistribution

Answer 24

Glucocorticoids, protease inhibitors

Question 25

Gingival hyperplasia

Answer 25

Phenytoin, verapamil

Question 26

Gout

Answer 26

Furosemide, thiazides, niacin, cyclosporine

Question 27

Myopathies

Answer 27

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoid "Fish N CHIPS Give you MYOPATHIES"

Question 28

Osteoporosis

Answer 28

Corticosteroids, heparin

Question 29

Photosensitivity

Answer 29

Sulfonamides, Amiodarone, Tetracycline "SAT for a PHOTO"

Question 30

Stevens-Johnson syndrome (Rash)

Answer 30

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital "bad RASH after a PEC SLAPP"

Question 31

SLE-like syndrome

Answer 31

Hydralazine, Isoniazid, Procainamide, Phenytoin

Question 32

Teeth (kids)

Answer 32

Tetracyclines

Question 33

Tendonitis, tendon rupture, and cartilage damage

Answer 33

Fluoroquinolones

Question 34

Diabetes insipidus

Answer 34

Lithium, demeclocycline

Question 35

Fanconi's syndrome

Answer 35

Expired tetracycline

Question 36

Hemorrhagic cystitis

Answer 36

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

Question 37

Interstitial nephritis

Answer 37

Methicillin, NSAIDs, Furosemide

Question 38

SIADH

Answer 38

Carbamazepine, cyclophosphamide

Question 39

Cinchonism

Answer 39

Quinidine, quinine

Question 40

Parkinson-like syndrome

Answer 40

antipsychotics, reserpine, metoclopramide

Question 41

Seizures

Answer 41

Isoniazid, Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide "with SEIZURES, I BITE My tongue"

Question 42

Tardive dyskinesia

Answer 42

Antipsychotics

Question 43

Antimuscarinic

Answer 43

Atropine, TCAs, H1 blockers, neuroleptics

Question 44

Disulfiram-like reaction

Answer 44

Metronidazole, certain cephalosporins, procarbazine, first-generation sulfonylureas

Question 45

Nephrotoxicity/ototoxicity

Answer 45

Aminoglycosides, vancomycin, loop diuretics, cisplatin