Drug reactions (all systems here)

Question 1

Name the sulfa drugs

Answer 1

Sulfonamide antibiotics
Sulfasalazine
Probenecid
Furosemide
Acetazolamide
Celecoxib
Thiazides
Sulfonylureas

– Fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria

Question 2

Coronary vasospasm 3

Answer 2

Cocaine
Sumatriptan
Ergot alkaloids

Question 3

Cutaneous flushing 5VANCE

Answer 3

Vancomycin
Adenosine
Niacin
Ca CB
Echinocandins

Question 4

Dilated cardiomyopathy

Answer 4

Anthracyclines (doxorubicin, daunorubicin)

prevent with Dexrazoxane

Question 5

Torsades de pointes

Answer 5

AntiArrhythmics (IA, III)
AntiBiotics (macrolides)
AntiCychotics (haloperidol)
AntiDepressants (TCAs)
AntiEmetics (ondansetron)

Question 6

Adrenocortical insufficiency

Answer 6

HPA suppression secondary to glucocorticoid withdrawal

Question 7

Hot flashes

Answer 7

Tamoxifen

Clomiphene

Question 8

Hyperglycemia

Answer 8

Tacrolimus
Protease inhibitors
Niacin
HCTZ
Corticosteroids

Question 9

Hypothyroidism

Answer 9

Lithium
Amiodarone
Sulfonamides

Question 10

Acute cholestatic hepatitis (jaundice)

Answer 10

Erythromycin

Question 11

Diarrhea

Answer 11

Acamprosate
Acarbose
Cholinesterase inhibitor (inc ACh, inc parasympathetics)
Colchicine
Erythromycin
Ezetimibe
Metformin
Misoprostol
Orlistat
Pramlintine
Quinidine
SSRIs

Question 12

Focal to massive hepatic necrosis

Answer 12

Halothane
Amanita phalloids (death cap mushrooms)
Valproid acid
Acetaminophen

Liver “HAVAc”

Question 13

Hepatitis

Answer 13

Rifampin
Isoniazid (anti TB, stops mycolic acid synthesis)
Pyrazinamide
Statis
Fibrates

Question 14

Pancreatitis

Answer 14

Didanosine
Corticosteroids
Alcohol
Valproid acid
Azathioprine
Diuretics (furosemine, HCTZ)

“Drugs Causing a Violent Abdominal Distress”

Question 15

Pill-induced esophagitis

Answer 15

Tetracyclines
Bisphosphonates
Potassium chloride

• Caustic effect minimized with upright posture and adequate water ingestion

Question 16

Pseudomembranous colitis

Answer 16

Clindamycin
Ampicillin
Cephalosporin

• abx predispose to superinfections by resistant C diff

Question 17

Agranulocytosis

Answer 17

Clozapine
Carbamazepine
Prophylthiouracil
Methimazole
Colchicine
Ganciclovir

“Can Cause Pretty Major Collapse of Granulocytes”

Question 18

Aplastic anemia

Answer 18

Carbamazepine
Methimazole
NSAIDs
Benzene
Chloramphenicol
Propylthiouracil

“Can’t Make New Blood Cell Properly”

Question 19

Direct Coombs-positive hemolytic anemia

Answer 19

Methyldopa

Penicillin

Question 20

Gray baby syndrome

Answer 20

Chloramphenicol

Question 21

Hemolysis in G6PD deficiency

Answer 21

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

“Hemolysis IS D PAIN”

Question 22

MegaloBLASTic anemia

Answer 22

Phenytoin
Methotraxate
Sulfa drugs

“Having a BLAST with PMS”

Question 23

Thrombocytopenia

Answer 23

Heparin

Question 24

Thrombotic complications

Answer 24

OCPs

Hormone replacement therapy

Question 25

Fat redistribution

Answer 25

Protease inhibitors Glucocorticoids "Fat PiG"

Question 26

Gingival hyperplasia

Answer 26

Phenytoin Ca CB Cyclosporine

Question 27

Hyperuricemia (gout)

Answer 27

``` Pyrazinamide Thiazides Furosemide Niacin Cyclosporine ``` "Painful Tophi and Feet Need Care"

Question 28

Myopathy

Answer 28

``` Fibrates Niacin Colchicine Hydroxychloroquine Interferon alpha Penicillamine Statins Glucocorticoids ```

Question 29

Osteoporosis

Answer 29

Corticosteroids | Heparin

Question 30

Photosensitivity

Answer 30

Sulfonamides Amiodarone Tetracyclines 5-FU "STAT For Photo"

Question 31

Rash (SJS)

Answer 31

Anti-epileptic drugs (Lamotrigine) Allopurinol Sulfa drugs Penicillin "Steven Johnson has epileptic allergy to sulfa drugs and penicillin"

Question 32

SLE-like syndrome

Answer 32

``` Sulfa drugs Hydralazine Isoniazid Procainamide Phenytoin Etanercept ``` "Having lupus is SHIPPE"

Question 33

Teeth discoloration

Answer 33

Tetracyclines

Question 34

Tendonitis, tendon rupture and cartilage damage

Answer 34

Fluoroquinolones

Question 35

Cinchonism

Answer 35

Quinine, quinidine

Question 36

Parkinson-like syndrome

Answer 36

Antipsychotics Reserpine Metoclopramide

Question 37

Seizures

Answer 37

``` Isoniazid (vit B6 def) Bupropion Imipenem/cilastatin Tramadol Enflurane ```

Question 38

Tardive dyskinesia

Answer 38

Antipsychotics | Metoclopramide

Question 39

Diabetes Insipidus

Answer 39

Lithium | Demeclocycline

Question 40

Fanconi syndrome

Answer 40

Tenofovir | Ifosfamide

Question 41

Hemorrhagic cystitis

Answer 41

Cyclophosphamide Ifosfamide Administer MESNA to prevent this

Question 42

Interstitial nephritis

Answer 42

Methicillin NSAIDs Furosemide

Question 43

SIADH

Answer 43

Carbamazepine Cyclophosphamide SSRIS "Can't Concentrate Serum Sodium"

Question 44

Dry cough

Answer 44

ACE inhibitors

Question 45

Pulmonary fibrosis

Answer 45

``` Methotraxate Nitrofurantoin Carmustine Bleomycin Bisulfan Amiodarone ``` "My Nose Cannot Breath Bad Air"

Question 46

Antimuscarinic (multiorgan)

Answer 46

Atropine TCAs H1 blocker Antipsychotics

Question 47

Disulfiran-like rxn

Answer 47

``` Metronidazole Cephalosporins Griseofulvin Procabazine 1st gen sulfonylureas ```

Question 48

Nephrotoxic/Ototoxic

Answer 48

Aminoglycosides Vancomycin Loop diuretics Cisplatin (respond to amifostine)