Drug Rxns

Question 1

Drug reaction: Coronary vasospasm

Answer 1

Causal agents: cocaine, sumatriptan, ergot alkaloids

Question 2

Drug reaction: cutaneous flushing

Answer 2

Causal agents: Vancomycin, Adenosine, Niacin, Ca2+ channel blockers (VANC)

Question 3

Drug reaction: dilated cardiomyopathy

Answer 3

Causal agents: anthracyclines (ex doxorubicin, daunorubicin); prevent with dexrazoxane

Question 4

Drug reaction: torsades de pointes

Answer 4

Causal agents: Class IA (ex quinidine) and class III (ex sotalol) anti-arrhythmics; macrolide antibiotics, antipsychotics, TCAs

Question 5

Drug reaction: Adrenocortical insufficiency

Answer 5

Causal agents: glucocortiocoid withdrawal

Question 6

Drug reaction: hot flashes

Answer 6

Causal agents: tamoxifen, clomiphene

Question 7

Drug reaction: hyperglycemia

Answer 7

Causal agents: Tacrolimus, Protease inhibitors, Niacin, HCTZ, Corticosteroids “taking pills necessitates having blood checked”

Question 8

Drug reaction: hypothyroidism

Answer 8

Causal agents: lithium, amiodarone, sulfonamides

Question 9

Drug reaction: acute cholestatic hepatitis, jaundice

Answer 9

Causal agents: Erythromycin

Question 10

Drug reaction: diarrhea

Answer 10

Causal agents: Metformin, Erythromycin, Colchicine, Orlistat, Acarbose “might excite colon on accident”

Question 11

Drug reaction: focal to massive hepatic necrosis

Answer 11

Causal agents: Halothane, Amanita phalloides (death cap mushroom), Valproid acid, Acetaminophen “Liver HAVAc”

Question 12

Drug reaction: hepatitis

Answer 12

Causal agents: rifampin, isoniazid, pyrazinamide, statins, fibrates

Question 13

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Question 14

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Answer 14

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Question 15

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Answer 15

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Question 16

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Question 17

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Answer 17

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Question 18

Drug reaction: pancreatitis

Answer 18

Causal agents: Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemid, HCTZ) “Drugs Causing A Violent Abdominal Distress”

Question 19

Drug reaction: psudomembranous colitis

Answer 19

Causal agents: Clindamycin, ampicillin, cephalosporins -> predispose to superinfection by c.diff (treat with oral vancomycin or oral metronidazole)

Question 20

Drug reaction: Agranulocytosis

Answer 20

Causal agents: Ganciclovir, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil “Gangs CCCrush Myeloblasts and Promyelocytes”

Question 21

Drug reaction: Aplastic anemia

Answer 21

Causal agents: Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil “Can’t Make New Blood Cells Properly”

Question 22

Drug reaction: Direct Coombs (+) hemolytic anemia

Answer 22

Causal agents: Methyldopa, penicillin

Question 23

Drug reaction: Gray baby syndrome

Answer 23

Causal agents: Chloramphenicol

Question 24

Drug reaction: Hemolysis in G6PD deficiency

Answer 24

Causal agents: Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (Hemolysis IS D PAIN)

Question 25

Drug reaction: Megaloblastic anemia

Answer 25

Causal agents: Phenytoin, MTX, Sulfa drugs "Having a blast with PMS"

Question 26

Drug reaction: Thrombocytopenia

Answer 26

Causal agents: Heparin

Question 27

Drug reaction: Thrombotic complications

Answer 27

Causal agents: OCP, hormone replacement therapy

Question 28

Drug reaction: Fat redistribution

Answer 28

Causal agents: Protease inhibitors, Glucocorticoids "Fat PiG"

Question 29

Drug reaction: Gingival hyperplasia

Answer 29

Causal agents: Phenytoin, Calcium channel blockers, cyclosporine

Question 30

Drug reaction: Hyperuricemia (gout)

Answer 30

Causal agents: Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine "Painful Tophi and Feet Need Care"

Question 31

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Question 32

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Question 33

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Question 34

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Answer 34

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Question 35

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Question 36

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Question 37

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Question 38

Drug reaction: Myopathy

Answer 38

Causal agents: Fibrates, niacin, colchicine, hydroxycholoroquine, INFalpha, penicillamine, statins, glucocorticoids

Question 39

Drug reaction: Osteoporosis

Answer 39

Causal agents: corticosteroids, heparin

Question 40

Drug reaction: photosensitivity

Answer 40

Causal agents: Sulfonamides, Amiodarone, Tetracyclines, 5-FU "SAT For Photo"

Question 41

Drug reaction: Rash (Stevens-Johnson syndrome)

Answer 41

Causal agents: anti-epileptic drugs (especially lamotrigine), allopurinol, sulfa drugs, penicillin

Question 42

Drug reaction: SLE-like syndrome

Answer 42

Causal agents: sulfa drugs, hydralazine, isoniazid, procainamide, phenytoin, etanercept

Question 43

Drug reaction: teeth discoloration

Answer 43

Causal agents: tetracyclines

Question 44

Drug reaction: tendonitis, tendon rupture and cartilage damage

Answer 44

Causal agents: fluoroquinolones

Question 45

Drug reaction: cinchonism (tinitis, hearing loss, blurred vision)

Answer 45

Causal agents: quinidine, quinine

Question 46

Drug reaction: Parkinson-like syndrome

Answer 46

Causal agents: antipsychotics, reserpine, metoclopramide

Question 47

Drug reaction: Seizures

Answer 47

Causal agents: Isoniazid (causes vitamin B6 deficiency), bupropion, imipenem/cilastatin, enflurane

Question 48

Drug reaction: tardive dyskinesia

Answer 48

Causal agents: antipsychotics, metoclopramide

Question 49

Drug reaction: diabetes insipidus

Answer 49

Causal agents: lithium, demeclocycline

Question 50

Drug reaction: Fanconi syndrome

Answer 50

Causal agents: expired tetracycline

Question 51

Drug reaction: Hemorrhagic cystitis

Answer 51

Causal agents: Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

Question 52

Drug reaction: interstitial nephritis

Answer 52

Causal agents: methicillin, NSAIDS, furosemide

Question 53

Drug reaction: SIADH

Answer 53

Causal agents: Carbamazepine, Cyclophosphamide, SSRIs "Can't Concentrate Serum Sodium"

Question 54

Drug reaction: Dry cough

Answer 54

Causal agents: ACE inhibitors

Question 55

Drug reaction: pulmonary fibrosis

Answer 55

Causal agents: Bleomycin, Amiodarone, Busulfan, Methotrexate "Breathing Air Badly from Medications"

Question 56

Drug reaction: Antimuscarinic

Answer 56

Causal agents: Atropine, TCAs, H1-blockers, antipsychotics

Question 57

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Question 58

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Question 59

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Question 60

Drug reaction: disulfiram-like reaction (increased hangover symptoms)

Answer 60

Causal agents: metronidazole, some cephalosporins, griseofulvin, procarbazine, 1st gen sulfonylureas

Question 61

Drug reaction: Nephrotoxicity/ ototoxicity

Answer 61

Causal agents: aminoglycosides, vancomycin, loop diruetics, cisplatin (may respond to amifostine)