Drug Safety Issues Flashcards
(20 cards)
What drugs should you avoid if cancer is present?
pioglitazone, dapagliflozin (bladder CA), GLP-1 RAs (thyroid, incl. medullary thyroid CA (MTC))
What drugs should you avoid if the patient is elderly?
Sulfonylureas, due to risk of hypoglycemia
What drugs should you avoid if gastroparesis, GI disorders are present?
GLP-1 RAs, pramlintide
What drugs should you avoid if genital infxn/UTI’s are present?
SGLT2i
What drugs should you avoid if heart failure is present?
TZDs, alogliptin, saxagliptin
What drugs should you avoid if hepatotoxicity is present?
TZDs, alogliptin
What drugs should you avoid if hypolgycemia is a concern?
insulin, SU, meglinitides if the dose is taken but the meal is skipped
What drugs should you avoid if hypotension/dehydration is a concern?
SGLT2i
What drugs should you avoid if hyperkalemia is a concern?
canagliflozin
What drugs should you avoid if hypokalemia is a concern?
insulin
What drugs should you avoid if hypersensitivity is a concern?
DPP-4i
What drugs should you avoid if ketoacidosis is a concern?
SGLT2i (RF are acute illness, dehydration, renal impairment)
What drugs should you avoid if lactic acidosis is a concern?
metformin
What drugs should you avoid if osteopenia/osteoporosis is a concern?
canagliflozin, TZDs
What drugs should you avoid if pancreatitis is a concern?
DPP-4i and GLP-1 RAs
What drugs should you avoid if peripheral neuropathy, PAD, and foot ulcers are a concern?
canagliflozin
What drugs should you avoid if retinopathy is a concern?
semaglutide injection
What drugs should you avoid if sulfa allergy, severe is a concern?
SU’s, or use it cautiously
What drugs should you avoid if renal insufficiency is a concern?
metformin, SGLT2i, exenatide, glyburide
What drugs should you avoid if weight gain is a concern?
risk with sulfonylureas, meglitinides, TZDs, and insulin
